Glial cell deficits are a key feature of schizophrenia: implications for neuronal circuit maintenance and histological differentiation from classical neurodegeneration
Molecular Psychiatry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
Abstract
Dysfunctional
glial
cells
play
a
pre-eminent
role
in
schizophrenia
pathophysiology.
Post-mortem
studies
have
provided
evidence
for
significantly
decreased
cell
numbers
different
brain
regions
of
individuals
with
schizophrenia.
Reduced
are
most
pronounced
oligodendroglia,
but
reduced
astrocyte
densities
also
been
reported.
This
review
highlights
that
oligo-
and
astroglial
deficits
key
histopathological
feature
schizophrenia,
distinct
from
typical
changes
seen
neurodegenerative
disorders.
Significant
oligodendrocytes
may
arise
two
ways:
(i)
demise
mature
functionally
compromised
oligodendrocytes;
(ii)
lack
due
to
failed
maturation
progenitor
cells.
We
analyse
detail
the
controversy
regarding
astrocytes.
Regardless
their
origin,
several
pathophysiological
consequences.
Among
these,
myelination
number
be
important
factor,
resulting
disconnectivity
between
neurons
observed
When
die,
it
appears
through
degeneration,
process
which
is
basically
reversible.
Thus,
therapeutic
interventions
help
rescue
or
improve
might
viable
option.
Since
antipsychotic
treatment
alone
does
not
seem
prevent
loss
deficits,
there
intense
search
new
options.
Current
proposals
range
application
antidepressants
other
chemical
agents
as
well
physical
exercise
engrafting
healthy
into
brains
patients.
Язык: Английский
Comprehensive review on single-cell RNA sequencing: A new frontier in Alzheimer's disease research
Ageing Research Reviews,
Год журнала:
2024,
Номер
100, С. 102454 - 102454
Опубликована: Авг. 12, 2024
Язык: Английский
Perineuronal oligodendroglia: functional specialisation or serendipitous location?
Ageing & Longevity,
Год журнала:
2025,
Номер
2. 2025, С. 129 - 135
Опубликована: Фев. 27, 2025
Oligodendrocytes
are
specialised
to
form
axonal
myelin
sheaths
in
the
central
nervous
system
(CNS),
which
is
essential
for
rapid
neuronal
communication.
The
adult
brain
also
contains
oligodendrocyte
precursor
cells
(OPC)
that
responsible
replacing
myelinating
oligodendrocytes
pathology
or
through
natural
‘wear
and
tear’,
as
well
enabling
plasticity
important
learning.
In
grey
matter,
OPC
often
situated
closely
apposed
perikarya
termed
perineuronal
oligodendroglia,
otherwise
appear
morphologically
functionally
indistinct
from
other
OPC.
There
evidence
of
a
subset
non-myelinating
oligodendroglial
simple
phenotypically
distinct
functional
significance
oligodendroglia
unknown
but
like
their
parenchymal
counterparts,
they
have
functions,
roles
protection,
metabolism
homeostasis.
this
respect,
it
significant
changes
implicated
neuropathology
aging,
including
multiple
sclerosis
Alzheimer’s
disease,
neuropsychiatric
disorders
such
schizophrenia.
Keywords:
oligodendroglia;
oligodendrocyte;
myelin;
cell;
satellite
axon;
neurone
Язык: Английский
Oligodendroglial changes in AGINGageing human white matter
Ageing & Longevity,
Год журнала:
2025,
Номер
2. 2025, С. 144 - 151
Опубликована: Фев. 27, 2025
Myelin
is
essential
for
superfast
conduction
of
axons
and
underpins
the
massive
computing
power
human
brain.
Myelinated
form
bundles
white
matter
to
connectome
which
one
most
prominent
features
cerebral
cortex.
produced
by
oligodendrocytes,
are
numerous
cells
in
matter,
together
with
oligodendrocyte
precursor
(OPC)
that
responsible
life-long
myelination.
cognitive
function
myelin
plasticity
required
learning.
It
noteworthy,
therefore,
shrinkage
loss
hallmarks
natural
ageing
more
severe
neuropathology,
including
multiple
sclerosis
Alzheimer’s
disease,
as
well
neuropsychiatric
disorders
such
schizophrenia.
The
precise
age-related
changes
oligodendroglial
gene
pathways
at
transcriptome
level
identify
decline
regeneration
a
key
factor
ageing.
Keywords:
oligodendrocyte;
myelin;
cell;
matter;
ageing;
Язык: Английский