Antidepressants and Weight Gain: An Update on the Evidence and Clinical Implications
Current Obesity Reports,
Год журнала:
2025,
Номер
14(1)
Опубликована: Янв. 3, 2025
Язык: Английский
Effects of antidepressants on body weight in patients treated in a naturalistic setting in Oman
Middle East Current Psychiatry,
Год журнала:
2025,
Номер
32(1)
Опубликована: Янв. 14, 2025
Abstract
Background
The
rising
use
of
antidepressants
is
critical
for
managing
mental
health
disorders,
but
weight
gain
a
concerning
side
effect,
particularly
with
certain
classes
like
TCAs
and
SSRIs.
This
study
aims
to
investigate
changes
in
Omani
patients
prescribed
paroxetine,
fluoxetine,
mirtazapine,
or
venlafaxine.
Method
A
cross-sectional
conducted
from
January
June
2023
at
Sultan
Qaboos
University
Hospital
recruited
adults
disorders
on
these
medications.
Weight
measurements
were
taken
baseline
follow-up,
clinically
significant
defined
as
≥
7%
increase.
Results
total
135
participants
analyzed,
showing
mean
5.54
kg,
60.7%
experiencing
gain.
Mirtazapine
paroxetine
exhibited
the
highest
average
increases
(7.51
kg
8.05
respectively)
compared
fluoxetine
(0.69
kg)
venlafaxine
(4.32
kg).
No
demographic
factors
influenced
(
p
=
0.213).
Conclusion
highlights
among
antidepressants,
mirtazapine
paroxetine.
underscores
importance
monitoring
clinical
practice
necessitates
further
investigations
into
individualized
treatment
strategies
manage
both
weight-related
concerns.
Язык: Английский
Antidepressant Effect of Crossopteryx Febrifuga Trunk Bark Aqueous Extract on Chronic Stress-Induced Depression in Rodents: A Sex-Based Approach
Опубликована: Янв. 1, 2025
Язык: Английский
Modulation of netrin-1/DCC signaling pathway by Jiawei Kongsheng Zhenzhong Pill improves synaptic structural plasticity in PSD rats
Journal of Pharmacological Sciences,
Год журнала:
2025,
Номер
157(4), С. 242 - 252
Опубликована: Фев. 22, 2025
Jiawei
Kongsheng
Zhenzhong
Pill(JKZP)
is
based
on
Pill
contained
in
the
Tang
Dynasty's
"Thousand
Golden
Prescriptions,"
which
exhibited
good
anti-ischemic
and
antidepressant
effects
previous
study.
However,
its
specific
post-stroke
depression
(PSD)
mechanism
are
not
clear.
This
study
aimed
to
investigate
of
JKZP
treatment
PSD
related
mechanisms.
The
decoction
was
first
analyzed
for
medicinal
chemical
composition
screened
representative
components
JKZP.
Middle
cerebral
artery
occlusion
(MCAO)
method
combined
with
solitary
rearing
chronic
unpredictable
mild
stress
(CUMS)
used
establish
a
rat
model
PSD,
observe
behavior
synaptic
plasticity
rats,
by
detecting
mRNA
level,
protein
expression
activity
Netrin-1/DCC
signaling
pathway-related
proteins.
results
showed
that
loganin,
β-asarone
other
pharmaceutical
ingredients,
have
been
reported
protect
against
ischemic
injury
effects.
significantly
improved
depression-like
rats
damage
pyramidal
neurons
medial
prefrontal
cortex
(mPFC)
rats.
Moreover,
increased
density
dendritic
spines
mPFC
gap
width
thickness
post-synaptic
density,
number
vesicles.
Real-Time
quantitative
reverse
transcription
PCR
(qRT-PCR),
Western
blotting,
pull-down
assays
revealed
netrin-1,
deleted
colorectal
cancer
(DCC),
focal
adhesion
kinase
(FAK)
expression,
elevated
p-FAK/FAK
ratio,
decreased
myosin
II
Ras
homolog
gene
family
member
A
(RhoA-GTP)
Taken
together,
can
affect
structural
remodeling
improve
depressive
manifestations
neuronal
regulating
molecules
netrin-1/DCC
pathway.
Язык: Английский
Special Issue “Depression: From Molecular Basis to Therapy”
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3844 - 3844
Опубликована: Апрель 18, 2025
Depression,
often
described
as
the
“silent
epidemic”
of
21st
century,
stands
a
complex
and
pervasive
mental
health
challenge
that
affects
millions
individuals
worldwide
[...]
Язык: Английский
Chronic, combinatorial targeting of NMDARs and 5-HT4Rs exerts extended behavioral effects against stress-induced perseverative behavior and hyponeophagia
Neuropsychopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 22, 2025
Язык: Английский
May the SSRIs play a role in the onset of peri- and post-menopausal cervical cancer?
Deleted Journal,
Год журнала:
2024,
Номер
6(7)
Опубликована: Июнь 25, 2024
Abstract
The
emergence
of
cancer-causing
bacteria
and
viruses
that
have
become
resistant
to
either
antibiotics
or
viral
treatment
is
often
attributed
their
overuse
in
people
livestock.
Intriguingly,
the
class
antidepressant
drugs,
such
as
selective
serotonin
reuptake
inhibitors
(SSRIs),
may
also
contribute
generating
microorganisms
with
a
profound
disturbing
role
local
cervix-vagina
homeostasis.
Therefore,
we
proposed
possible
involvement
SSRIs
onset
growth
cervical
cancer
(CC),
which
based
on
some
empirical
considerations,
(i)
number
women
diagnosed
post-menopausal
CC
almost
equivalent
depressive
problems,
(ii)
proven
affection
both
vaginal
intestinal
microbiota,
(iii)
essential
microbiota
immune
response
against
oncogenic
pathogens,
including
human
papillomavirus
Chlamydia
trachomatis
(
C.
),
(IV)
favoring
rise
antibiotic-resistant
microorganisms,
(V)
inhibitory
effect
estradiol-serotonin-prolactin
axis.
These
features
are
important
overproduction
reactive
oxygen
species,
responsible
for
different
harmful
activities
higher
cell
membrane
permeability
porosity,
hyperstimulation
transcription,
translational
activities,
overall
stress
check-point
genes
involved
ATP
synthesis,
DNA
breaks,
abnormal
mutations.
This
paper's
results
suggested
reconsidering
efficacy
long-term
use
since
increase
prescriptions
mainly
due
rather
than
diagnoses
per
se,
secondly
little
known
about
consequences
use.
evidence
supports
drugs
increasing
risk
was
searched
discussed.
Язык: Английский
Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial
Narra J,
Год журнала:
2024,
Номер
4(3), С. e1342 - e1342
Опубликована: Окт. 30, 2024
The
coexistence
of
depression
and
type
2
diabetes
mellitus
(T2DM)
can
significantly
worsen
disease
prognosis
lower
quality
life.
Emerging
evidence
suggests
that
vitamin
D
deficiency
contributes
to
the
progression
T2DM
is
closely
associated
with
development
depression.
aim
this
study
was
investigate
effects
cholecalciferol
on
in
patients
T2DM,
exploring
its
mechanisms
by
analyzing
impact
C-peptide,
serotonin,
neurotrophin-3
levels.
A
double-blind,
randomized,
placebo-controlled
clinical
trial
conducted
at
Cipto
Mangunkusumo
General
Hospital,
Jakarta,
Indonesia,
from
April
2021
September
2022.
Patients
depressive
symptoms
were
randomly
assigned
two
groups:
received
4000
IU
daily
a
placebo
for
12
weeks.
Depression
assessed
using
Beck
Inventory-II
(BDI-II)
before
weeks
after
intervention.
levels
measured
end
fourth
week
intervention
enzyme-linked
immunosorbent
assay
(ELISA)
method.
Between-group
comparisons
made
independent
Student
t-tests
Mann-Whitney
U
tests.
Paired
or
Wilcoxon
tests
applied
within-group
between
pre-
post-intervention.
total
70
included
study,
comprising
38
group
32
group.
C-peptide
increased
compared
(p=0.006).
No
significant
differences
observed
serotonin
NT-3
had
greater
reduction
BDI-II
scores
(p<0.001).
This
highlights
taking
might
help
ease
mild
moderate
enhancing
c-peptide
levels,
though
are
still
unclear.
Язык: Английский
Urinary Metabolite Profiles of Participants with Overweight and Obesity Prescribed a Weight Loss High Fruit and Vegetable Diet: A Single Arm Intervention Study
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4358 - 4358
Опубликована: Дек. 17, 2024
Background/Objectives:
Thus
far,
no
studies
have
examined
the
relationship
between
fruit
and
vegetable
(F
V)
intake,
urinary
metabolite
quantities,
weight
change.
Therefore,
aim
of
current
study
was
to
explore
changes
in
metabolomic
profiles
during
after
a
10-week
loss
intervention
where
participants
were
prescribed
high
F
V
diet
(7
servings
daily).
Methods:
Adults
with
overweight
obesity
(n
=
34)
received
medical
nutrition
therapy
counselling
increase
their
intakes
national
targets
day).
Data
collection
included
weight,
dietary
urine
samples
at
baseline
week
2
10.
Urinary
quantified
using
1H
NMR
spectroscopy.
Machine
learning
statistical
approaches
employed
identify
novel
urine-based
biomarkers
associated
patterns
weeks
Metabolic
appearing
response
Metabolite
Set
Enrichment
Analysis
(MSEA).
Results:
Energy
intake
significantly
lower
(p
0.02)
10
compared
baseline.
Total
higher
<
0.05).
In
total,
123
metabolites
quantified.
At
10,
21
showed
significant
relative
Of
these,
11
also
changed
2.
These
overlapping
acetic
acid,
dimethylamine,
choline,
fumaric
glutamic
L-tyrosine,
histidine,
succinic
uracil,
histamine,
2-hydroxyglutarate.
Ridge
Classifier
Linear
Discriminant
provided
best
prediction
accuracy
values
0.96
when
level
Conclusions:
represent
potential
candidate
reduction
energy
intake.
Further
are
needed
validate
these
findings
larger
population
studies.
Язык: Английский