Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Окт. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Язык: Английский

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Copper, Iron, Cadmium, and Arsenic, All Generated in the Universe: Elucidating Their Environmental Impact Risk on Human Health Including Clinical Liver Injury

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6662 - 6662

Опубликована: Июнь 17, 2024

Humans are continuously exposed to various heavy metals including copper, iron, cadmium, and arsenic, which were specifically selected for the current analysis because they among most frequently encountered environmental mankind industrial pollutants potentially causing human health hazards liver injury. So far, these issues poorly assessed remained a matter of debate, also due inconsistent results. The aim actual report is thoroughly analyze positive as well negative effects four on health. Copper iron correctly viewed pollutant elements essential maintaining part important enzymes metabolic pathways. Healthy individuals prepared through genetically based mechanisms maintain cellular copper homeostasis, thereby circumventing or reducing hazardous organ injury excessive amounts entering body. In few humans with gene aberration, however, may develop excessively accumulated can lead Wilson disease substantial deposition hemochromatosis. At molecular level, toxicities some traced back Haber Weiss Fenton reactions involving reactive oxygen species formed in course oxidative stress. On other hand, homeostasis cadmium arsenic cannot be provided, their life-long organs. Consequently, represent leading higher disability-adjusted life years increased mortality rates cancer non-cancer diseases. For unknown reasons, rarely observed. sum, good except those hemochromatosis at risk radical formation, while lack any beneficial but rather focus disability potential cancer. Primary efforts should emission metals.

Язык: Английский

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A Multimode fluorescent sensor for sequential detection of Cu2+ and cysteine as well as pH sensor with real sample Applications: Extensive experimental and DFT studies

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 327, С. 125414 - 125414

Опубликована: Ноя. 9, 2024

Язык: Английский

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Copper's dual role: Reviewing its impact on liver health and disease

International Immunopharmacology, Год журнала: 2025, Номер 152, С. 114391 - 114391

Опубликована: Март 12, 2025

Язык: Английский

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Gut-Heart Axis: Microbiome Involvement in Restrictive Cardiomyopathies

Biomedicines, Год журнала: 2025, Номер 13(1), С. 144 - 144

Опубликована: Янв. 9, 2025

An intriguing aspect of restrictive cardiomyopathies (RCM) is the microbiome role in natural history disease. These are often difficult to diagnose and so result significant morbidity mortality. The human microbiome, composed billions microorganisms, influences various physiological pathological processes, including cardiovascular health. Studies have shown that gut dysbiosis, an imbalance composition intestinal bacteria, can contribute systemic inflammation, a key factor many conditions. increase permeability, frequently caused by allows bacterial endotoxins enter bloodstream, activating inflammatory pathways exacerbate cardiac dysfunction. Recent reports highlight potential amyloidogenesis, as certain bacteria produce proteins accelerate formation amyloid fibrils. Concurrently, advancements amyloidosis treatments sparked renewed hopes, marking promising era for managing these kinds diseases. findings suggest gut-heart axis may be development progression disease like RCM, opening new paths therapeutic intervention. aim this review provide detailed overview axis, focusing on RCM.

Язык: Английский

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CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2‐Atp7b signalling axis in depression after traumatic brain injury in a mouse model

Clinical and Translational Medicine, Год журнала: 2024, Номер 14(11)

Опубликована: Ноя. 1, 2024

Язык: Английский

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Biomonitoring of metals in the blood and urine of waste recyclers from exposure to airborne fine particulate matter (PM2.5)

Journal of Environmental Health Science and Engineering, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 21, 2024

Язык: Английский

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Phage display technology in ecotoxicology: phage display derived unique peptide for copper identification in aquatic samples

Microbial Cell Factories, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 8, 2025

Ecotoxicology is essential for the evaluation and comprehension of effects emergency pollutants (EP) such as heavy metal ions on natural environment. EPs pose a substantial threat to health humans proper functioning global ecosystem. The primary concern exposure animals through contaminated water. presence in drinking water ought be monitored accordance with World Health Organization regulations. Among numerous harmful ions, copper are responsible variety human diseases. This study investigates application phage display screening method toxicological targets, served main focus. To identify Cu-binding M13 clones unique peptides assess their affinity utilized Escherichia coli factories producing recombinant bacteriophages, modified biopanning procedure an ELISA assay. research highlights increasing importance tool ecotoxicology. We synthesized selected peptide enable rapid optical detection Cu(II) aqueous solutions. By incorporating dansyl group into designated sequence, we implemented fluorescence assays real-time measurements. Cu2+- binding peptide's efficacy was confirmed spectroscopic measurements, which allowed response times high selectivity. technique successfully applied develop fluorescent peptide-based chemosensor that exhibited selectivity sensitivity Cu2+.

Язык: Английский

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Liver ischemia reperfusion injury: Mechanisms, cellular pathways, and therapeutic approaches

International Immunopharmacology, Год журнала: 2025, Номер 150, С. 114299 - 114299

Опубликована: Фев. 16, 2025

Язык: Английский

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An APTES-modified thiophene-based Schiff base microelectromechanical sensor for the analysis of Cu2+ ions in water: Counterion and pH effects: Experimental and DFT study

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113325 - 113325

Опубликована: Март 1, 2025

Язык: Английский

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