Pharmacokinetics, Withdrawal Time, and Physiological Effects of Single Oral Administration of Enrofloxacin in Dybowski’s Frog (Rana dybowskii) DOI Creative Commons
Yanan Wang, Jing Wang, Ran Zhao

и другие.

Antibiotics, Год журнала: 2025, Номер 14(4), С. 417 - 417

Опубликована: Апрель 19, 2025

Background: As a broad-spectrum fluoroquinolone, enrofloxacin (ENR) is commonly employed to manage bacterial infections in aquatic species. Nevertheless, there have been no documented pharmacokinetic and residue studies conducted on Dybowski’s frog (Rana dybowskii). Therefore, the objective of our study was characterize pharmacokinetics (PK) ENR its metabolite ciprofloxacin (CIP) R. dybowskii, establish withdrawal times, evaluate physiological effects associated with administration. Methods: Adult Rana dybowskii (120 individuals; 60 males females) were sex-separated acclimated four tanks. Prior dosing, three females randomly selected as untreated controls (without administration). Following oral gavage (10 mg/kg), blood, liver, kidney tissues collected at 0.25, 0.5, 1, 1.5, 2, 4, 6, 8, 12, 24, 36, 48, 72 h (n = 6) for analysis. Muscle oviduct additionally sampled 3, 7, 15, 30 days post-dose content determination. Serum/tissue concentrations measured via Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) analyzed using non-compartmental model (WinNonLin 6.1 software) calculate PK parameters including peak time (Tmax), concentration (Cmax), area under curve (AUC0−t). In studying physiology administration, biochemical enzyme activities gene expressions liver intestine assessed post-ENR Results: demonstrated rapid absorption extensive distribution dybowskii. The periods determined be over 33 34 an increase immune enzymes (AKP (alkaline phosphatase) ACP (acid phosphatase)) well glycolytic (HK (hexokinase), (pyruvate kinase), PFK (phosphofructokinase)). Antioxidant levels, specifically SOD (superoxide dismutase) CAT (catalase), peaked 1.5 administration but subsequently declined by 8 mark. Additionally, following treatment, IGF1, PI3K, Akt exhibited up-regulation, whereas Keap1 GYS1 showed down-regulation. Conclusions: dosage 10 mg/kg significantly enhances AKP ACP, promotes glycolysis, activates Keap1/Nrf2 PI3K-Akt signaling pathways These findings foundation rational application determination times aquaculture.

Язык: Английский

New series of fluoroquinolone derivatives as potential anticancer Agents: Design, Synthesis, in vitro biological Evaluation, and Topoisomerase II Inhibition DOI
Mina E. Adly, Azza T. Taher,

Fakher M. Ahmed

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер 156, С. 108163 - 108163

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

1
Revealing improved photocatalytic decomposition of fluoroquinolone antibiotic over hydrothermally grown perovskite SrTi1-xFexO3 nanostructures DOI
Totsaporn Suwannaruang, Kitirote Wantala‬‬‬‬‬‬‬‬‬‬‬,

Piyanut Phuthongkhao

и другие.

Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 106001 - 106001

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Tuning the Lipophilicity of New Ciprofloxacin Derivatives in Selected Eskape Bacteria with Emphasis on E. Coli Mutants DOI
Ryszard Ostaszewski,

Elisabetta Cassese,

Dominik Koszelewski

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Tuning the lipophilicity of new ciprofloxacin derivatives in selected ESKAPE bacteria with emphasis on E. coli mutants DOI

Elisabetta Cassese,

Dominik Koszelewski, Anna Brodzka

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер 158, С. 108324 - 108324

Опубликована: Март 4, 2025

Язык: Английский

Процитировано

0
An Overview of Quinolones as Potential Drugs: Synthesis, Reactivity and Biological Activities DOI Creative Commons
Ayoub El‐Mrabet, Amal Haoudi,

Youssef Kandri-Rodi

и другие.

Organics, Год журнала: 2025, Номер 6(2), С. 16 - 16

Опубликована: Апрель 3, 2025

Quinolones represent one of the largest classes synthetic antibiotics used in both human and veterinary medicine. Since discovery nalidixic acid, a substantial body research has been carried out on quinolones, resulting synthesis several quinolone derivatives with exceptional pharmacology. In addition to their antibacterial action, quinolones have broad spectrum diverse biological activities. this regard, present review examines literature recent years describing protocols, reactivity properties, particular emphasis antibacterial, antimalarial, antitrypanosomal, antileishmanial, antiviral anticancer activities famous class molecules. Finally, highlights potential as preferred pharmacophores medicinal chemistry. The aim is highlight innovative aspects rational design new therapeutic agents structural motif, face emerging antibiotic resistance urgent need for active

Язык: Английский

Процитировано

0
Pharmacokinetics, Withdrawal Time, and Physiological Effects of Single Oral Administration of Enrofloxacin in Dybowski’s Frog (Rana dybowskii) DOI Creative Commons
Yanan Wang, Jing Wang, Ran Zhao

и другие.

Antibiotics, Год журнала: 2025, Номер 14(4), С. 417 - 417

Опубликована: Апрель 19, 2025

Background: As a broad-spectrum fluoroquinolone, enrofloxacin (ENR) is commonly employed to manage bacterial infections in aquatic species. Nevertheless, there have been no documented pharmacokinetic and residue studies conducted on Dybowski’s frog (Rana dybowskii). Therefore, the objective of our study was characterize pharmacokinetics (PK) ENR its metabolite ciprofloxacin (CIP) R. dybowskii, establish withdrawal times, evaluate physiological effects associated with administration. Methods: Adult Rana dybowskii (120 individuals; 60 males females) were sex-separated acclimated four tanks. Prior dosing, three females randomly selected as untreated controls (without administration). Following oral gavage (10 mg/kg), blood, liver, kidney tissues collected at 0.25, 0.5, 1, 1.5, 2, 4, 6, 8, 12, 24, 36, 48, 72 h (n = 6) for analysis. Muscle oviduct additionally sampled 3, 7, 15, 30 days post-dose content determination. Serum/tissue concentrations measured via Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) analyzed using non-compartmental model (WinNonLin 6.1 software) calculate PK parameters including peak time (Tmax), concentration (Cmax), area under curve (AUC0−t). In studying physiology administration, biochemical enzyme activities gene expressions liver intestine assessed post-ENR Results: demonstrated rapid absorption extensive distribution dybowskii. The periods determined be over 33 34 an increase immune enzymes (AKP (alkaline phosphatase) ACP (acid phosphatase)) well glycolytic (HK (hexokinase), (pyruvate kinase), PFK (phosphofructokinase)). Antioxidant levels, specifically SOD (superoxide dismutase) CAT (catalase), peaked 1.5 administration but subsequently declined by 8 mark. Additionally, following treatment, IGF1, PI3K, Akt exhibited up-regulation, whereas Keap1 GYS1 showed down-regulation. Conclusions: dosage 10 mg/kg significantly enhances AKP ACP, promotes glycolysis, activates Keap1/Nrf2 PI3K-Akt signaling pathways These findings foundation rational application determination times aquaculture.

Язык: Английский

Процитировано

0