An updated review of pulmonary radiological features of acute and chronic pulmonary COVID-19

Current Opinion in Pulmonary Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Purpose of review Significant progress has been made in our understanding the acute and chronic clinical radiological manifestations coronavirus-19 (COVID-19). This article provides an updated on pulmonary COVID-19, while highlighting key imaging features that can identify distinguish COVID-19 pneumonia its sequelae from other diseases. Recent findings Acute typically presents with organizing computed tomography (CT). In cases severe disease, patients clinically to respiratory distress syndrome, which manifests as diffuse alveolar damage CT. The most common finding is ground-glass opacities, commonly resolves, well subpleural bands reticulation. Pulmonary fibrosis overall rare complication characteristic features, including architectural distortion, traction bronchiectasis. Summary Chest CT be a helpful adjunct tool both diagnosing managing sequelae. It high-risk guide decision-making, particularly or complicated disease. Follow-up detect persistent lung abnormalities associated long COVID appropriate management.

Язык: Английский

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Morphopathology of the lesions induced by SARS-CoV-2 infection in the lungs

Romanian Journal of Morphology and Embryology, Год журнала: 2025, Номер 65(4), С. 637 - 645

Опубликована: Фев. 13, 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection spread rapidly from China around the world, causing worst pandemic since beginning of 21st century. Although disease named 2019 (COVID-19) has multiple organ symptoms, main pathological lesions occur in lung, failure, pulmonary embolism, secondary bacterial pneumonia and fibrosis. Despite best efforts researchers, pathogenesis SARS-CoV-2-induced cellular tissue damage organs systems is poorly understood. Therefore, our study, we aimed to highlight their extent, which could explain complex symptomatology presented by patients who died with distress (ARDS). The study was performed on a number 36 diagnosed COVID-19 under legally suspicious conditions, requiring autopsy within Romanian Forensic Medicine Institutes. All local inflammatory reaction pneumonic type, exudative proliferative phenomena, intra-alveolar interstitial infiltrates formed lymphocytes, macrophages neutrophilic granulocytes, congested or ruptured blood vessels hemorrhages, thrombosis, proliferation fibroblasts transformed into myofibroblasts presence granulation that remodeled entire lung parenchyma.

Язык: Английский

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Thrombektomie: PAP sinkt, RV-Funktion verbessert

CardioVasc, Год журнала: 2025, Номер 25(2), С. 35 - 39

Опубликована: Апрель 1, 2025

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Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy

Respiratory Research, Год журнала: 2024, Номер 25(1)

Опубликована: Дек. 4, 2024

HAdV-7 is a prevalent pathogen that can cause severe pneumonia in children. Previous studies have shown significant increase serum levels of vascular permeability factor (VPF/VEGF) and viral load pediatric patients with fatal infection, suggesting potential damage to the pulmonary endothelium. Further research necessary elucidate underlying mechanism. The human lung microvascular endothelial cell line-5a CD46 mice were used for vitro vivo experiments, respectively. RNA-seq was employed correlative omics analysis. Viral infection copy status examined using transmission electron microscopy observe virus particles, immunofluorescence detect protein Hexon, qPCR assess fiber gene copies. Various methods, including ELISAs VEGF other injury markers, CCK8 assay viability, flow cytometry endothelium numbers, evaluate damage. Acute severity evaluated by scoring pathological inflammation measuring permeability. Autophagy activation assessed observing autophagosomes validating marker proteins. GSEA analysis showed enrichment sets related functions (barrier, defense, regeneration) ALI HAdV-7-infected group. GO indicated an autophagy-related pathways linked death. Subsequently, successful signs replication observed endothelium, cytopathic effects, intracellular virions, increased Endothelial injury, mitochondrial damage, decreased elevated markers such as VEGF, sICAM-1, sVCAM-1, E-selectin, ESM1, MCP1, IL1β after infection. Additionally, evidence leaky blood vessels observed, progressive weight loss, permeability, consolidation. Furthermore, induced autophagosome formation triggered complete autophagy. Importantly, inhibiting autophagic flux reduced load, improved survival rate, alleviated vessel leakage, mitigated inflammation. successfully infects replicates effectively, causing high expression serum, well ALI/ARDS. inhibitors alleviate inhibit replication, relieve leakage from vasculature, reduce

Язык: Английский

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Trombose e SARS-CoV-2: uma associação possível?

Brazilian Journal of Health Review, Год журнала: 2024, Номер 7(3), С. e70494 - e70494

Опубликована: Июнь 12, 2024

A compreensão da relação entre a Síndrome Respiratória Aguda Grave causada pelo Coronavírus 2 – SARS-CoV-2 e trombose é de fundamental importância. Eventos podem ocorrer tanto na fase aguda, quanto em pacientes convalescentes, também naqueles já considerados curados COVID-19. capacitação dos farmacêuticos clínicos identificação prevenção pode garantir intervenções eficazes melhorar os desfechos clínicos. Este estudo visa investigar conexão SARS-CoV-2, avaliando elementos associados eventos trombóticos infectados. coleta dados foi realizada nas bases PubMed, Scopus Web of Science, utilizando descritores específicos relacionados ao tema operadores booleanos para precisão resultados. Durante infecção por ocorrem modificações no sistema vascular resposta imunológica. Fatores como desordens coagulação, danos endoteliais, inflamação persistente, tempestade citocinas, presença proteína Spike do vírus influência fator von Willebrand (FvW) são recorrentes pós-COVID-19. venosa profunda mais frequente que tiveram SARS-CoV-2. está associada um aumento risco devido múltiplos fatores interligados, disfunção endotelial, inflamatória exacerbada desregulação coagulação. desses torna-se, então, muito relevante desenvolver estratégias profiláticas terapêuticas eficazes, visando reduzir ou prevenir o impacto saúde cardiovascular, mortalidade complicações trombóticas.

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A Novel Facet of In-Hospital Food Consumption Associated with Hospital Mortality in Patients with Scheduled Admission—Addition of a Study Protocol to Test the Existence of Effects of COVID-19 in the Same Study in the Post-COVID-19 Period

Nutrients, Год журнала: 2024, Номер 16(14), С. 2327 - 2327

Опубликована: Июль 19, 2024

Background: Humankind has faced unexperienced pandemic events since 2020. Since the COVID-19 calmed down, we felt need to verify whether in-hospital mortality had worsened compared pre-pandemic conditions due pandemic. Objective: To test hypothesis that daily food consumption is associated with during hospitalization and provide baseline data examine effects of exist or not in post-pandemic period. Methods: All hospitalized patients staying a single institution on third Thursday May, August, November, following February were included. Compared data: (1) among four seasons, (2) between age < 75 vs. ≥75 years, (3) <75% ≥75% food, (4) logistic regression analysis identify factors mortality. Results: In 365 inpatients, results obtained: no seasonality effect mortality, novel cutoff value 75% hospital requirement was used poor survivors, showed low consumption, as predictor high Conclusions: A small eater significantly higher scheduled Then, study protocol proposed existence same post-COVID-19 This is, our knowledge, first proposal period clinical nutritional areas.

Язык: Английский

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Pulmonary diffusing capacity among individuals recovering from mild to moderate COVID-19: a cross-sectional study

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 5, 2024

Impaired pulmonary diffusing capacity for carbon monoxide (DLCO) following COVID-19 has been consistently reported among individuals recovering from severe-critical infection. However, most long COVID cases follow non-severe COVID-19. We assessed DLCO with mild to moderate acute illness. A cross-sectional study of adults COVID, at a recovery clinic > 3 months the onset infection, during 2020–2021. Participants subjectively ranked their dyspnea severity based on its impact daily living and underwent comprehensive function testing (PFT). Clinical correlates impaired (defined as < 80%) were using multivariable logistic regression models. total 458 individuals, mean age 45 (SD 16) 246 (54%) whom are women, evaluated an average ~ 4 The frequent PFT impairment was reduced DLCO, identified 67 (17%) cohort. included women (odds ration [OR] 3.64, 95% confidence interval [CI] 1.78–7.45, p 0.001), cigarette smoking (OR 2.25, CI 1.14–4.43, = 0.019), moderate-severe 2.77, 1.39–5.50, 0.004). BMI inversely correlated 0.90, 0.85–0.96 per 1 unit, 0.002). not uncommon Women greater risk, subjective DLCO. Clinicians can rely self-reported significant guide further assessment.

Язык: Английский

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Post-COVID-19 Condition and Pulmonary Embolism

Journal of Multidisciplinary Healthcare, Год журнала: 2024, Номер Volume 17, С. 6153 - 6159

Опубликована: Дек. 1, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes post-acute sequelae of disease 2019 (COVID-19), including pulmonary vasculopathy, increasing thrombotic risk. Screening and treating survivors are essential to reduce associated disabilities. We aim investigate the clinical characteristics patients with post-COVID-19 condition embolism, as well their health-related quality life one year after COVID-19 diagnosis.

Язык: Английский

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