Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 7, 2025

Following prolonged exposure to hypoxic conditions, for example, due ascent high altitude, aging or stroke, cognitive deficits can develop. The exact nature and genesis of hypoxia-induced remain unresolved. Curcumin has been reported stimulate neurogenesis reduce neuronal degeneration. This study aimed investigate the effect curcumin on in hypoxic-brain injury mice its potential mechanism. Eight-week-old male C57BL/6J were normobaric-hypoxia (13%O2) 14 days establish models. Morris water maze novel object recognition used detect function each mouse. Immunofluorescence assays, including Fluoro-Jade C (FJC) bromodeoxyuridine (BrdU), degeneration neurogenesis. Thy1-YFP transgenic synapse plasticity. Our results showed that administration rescued impaired cognition mice, shown as enhanced BrdU+ dendritic spine hippocampus. At molecular level, was found promote expression brain-derived neurotrophic factor (BDNF) postsynaptic density protein 95 (PSD95). primary hippocampal neuron detection could growth. In conclusion, our indicates curcumin, increased BDNF PSD95 contacted with interneurons, salvaged interneurons may normalize ambient neuroplasticity, resulting preservation processes well contributing improve performance.

Язык: Английский

---

Aerobic exercise and metformin attenuate the cognitive impairment in an experimental model of type 2 diabetes mellitus: focus on neuroinflammation and adult hippocampal neurogenesis

Metabolic Brain Disease, Год журнала: 2025, Номер 40(1)

Опубликована: Янв. 7, 2025

Язык: Английский

---

Advances in neural stem cells in aging and age-related neurodegenerative diseases

Ageing and Neurodegenerative Diseases, Год журнала: 2025, Номер 5(1)

Опубликована: Янв. 26, 2025

With aging, neural stem cells (NSCs) undergo age-related changes, including metabolic abnormalities, disrupted protein homeostasis, mitochondrial dysfunction, reduced genetic stability, and more notably, a diminished capacity for proliferation differentiation. These changes may contribute to the development of neurodegenerative diseases such as Alzheimer’s disease (AD) Parkinson’s (PD). In these conditions, disease-specific pathological interact with alterations NSCs, resulting in impairment neurogenesis, which further leads cognitive, mood, motor decline. Based on potential therapeutics targeting neurogenesis cell-based therapies restore functions NSCs replace degenerated neurons, aiming ameliorate functional decline diseases. While therapies, cell transplantation secretome therapy, show great treatment diseases, challenges tumorigenesis, immune rejection, extraction or storage need be addressed. A better understanding age- disease-related underlying mechanism driving benefits drawbacks therapeutic approaches provide insights novel disease-modifying interventions future

Язык: Английский

---

The Antioxidant Role of Aromatic Plant Extracts in Managing Neurodegenerative Diseases: A Comprehensive Review

Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111253 - 111253

Опубликована: Фев. 1, 2025

Neurodegenerative diseases (NDDs) are a class of cognitive and motor disorders including Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), Amyotrophic Lateral Sclerosis (ALS), others. They caused by lesions in cells tissues the central nervous system, resulting corresponding dysfunctions consequent decline functions. Neural extremely vulnerable to oxidative stress, which plays critical biological roles NDDs. Aromatic compounds found extensively natural plants have substantial effects anti-oxidative stress damage, not only wide range research applications cosmetics, foods, etc., but also frequently utilized treatment various system diseases. This review summarizes relevant mechanisms NDDs (AD, PD, HD, ALS) reviews aromatic such as polyphenols, terpenoids, flavonoids that can be used management neurodegenerative diseases, well their specific antioxidant action. will serve reference for future experimental studies on illnesses while offering fresh insights into clinical therapy.

Язык: Английский

---

Exploring the potential anti-senescence effects of soybean-derived peptide Soymetide in mice hippocampal neurons via the Wnt/β-catenin pathway

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 25, 2025

Soybean-based foods enhance cognitive functions by influencing hippocampal mechanisms. These salutary effects have so far been attributed to isoflavones present in soybeans. Considering cellular senescence contributes decline and that no specific soy-derived peptides are known for their potential mitigate senescence, we examined the efficacy of a thirteen amino acid peptide, Soymetide, on doxorubicin-induced mice model. Soymetide pretreatment lowered markers p53, p21 p16, pro-inflammatory cytokines, Senescence β-Galactosidase staining while enhancing mature neuronal marker NeuN hippocampus. This anti-senescent effect was comparable with well-known senolytic combination (dasatinib quercetin). Research indicates Wnt signaling influences our findings here demonstrate doxorubicin decreased Wnt3a, p-LRP6, Frizzled, Dishevelled, Axin1, β-catenin levels increased GSK-3β, mitigated these effects. Additionally, upon inhibition Wnt/β-catenin pathway, Soymetide's ability reduce restore expression reduced. We validated anti-senescence impact neurons co-immunostaining indicators alongside assessed it primary neurons. Further examining survival revealed blocked loss Nissl-stained surviving learning-memory performances, measured Y-Maze Passive Avoidance tests, which inhibitors could counteract. In conclusion, study identifies novel Wnt/β-catenin-linked mechanism demonstrates effectiveness reversing this process. Hence, suggests therapeutic application addressing associated aging.

Язык: Английский

---

Traditional Chinese Medicine-derived formulations and extracts modulating the PI3K/AKT pathway in Alzheimer’s disease

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 17, 2025

Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by memory decline, cognitive impairment, and behavioral abnormalities. Pathologically, AD marked neurofibrillary tangles caused excessive phosphorylation of Tau protein abnormal deposition β-amyloid (Aβ) in the brain. The PI3K/AKT signaling pathway plays crucial role development, survival, metabolic regulation central nervous system, particularly neuronal growth, differentiation, apoptosis. However, this often inhibited patients.In recent years, studies have shown that herbal formulations extracts derived from Traditional Chinese Medicine (TCM) can regulate pathway, thereby improving pathological models. This study reviews fundamental research on both active metabolites compound TCM for treatment AD, targeting pathway.Keywords include "Alzheimer's disease" "AD" "dementia" "PI3K" "AKT" "Traditional Medicine" "Chinese herbology" medicine" "TCM".The based relevant literature published over past 15 primarily sourced electronic databases such as Web Science, PubMed, CNKI, Wanfang, VIP databases.The findings indicate mitigate pathology regulating reducing Aβ deposition, inhibiting inflammatory responses oxidative stress, alleviating enhances our understanding anti-AD mechanisms through offers new insights future.

Язык: Английский

---

Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiency

Biotechnology Advances, Год журнала: 2025, Номер unknown, С. 108568 - 108568

Опубликована: Март 1, 2025

Язык: Английский

---

The possible role of neurogenesis activators in temporal lobe epilepsy: State of art and future perspective

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177646 - 177646

Опубликована: Апрель 1, 2025

Neurogenesis is a complex process by which the neurons and supporting cells of central nervous system (CNS) are generated neural stem cells. Adult hippocampal neurogenesis (AHN) in human brain an active during life plays critical role regulation memory, cognition, mood. It has been shown that epilepsy linked with dysregulation AHN. Of note, AHN very sensitive to pathological electrical stimuli epileptic seizures, result induction acute inhibition chronic epilepsy. Epileptic seizure-induced neurodegeneration activates mobilization substitute for loss temporal lobe (TLE), most refractory type Moreover, recurrent seizures TLE trigger certain regions. However, transient seizure terminated 1-4 weeks following status epilepticus (SE). Nevertheless, adult dramatically reduced associated development cognitive impairment TLE. These findings indicate severity seizures. Hence, activators may attenuate pathogenesis Therefore, this review aims discuss explain beneficial how could be effective management

Язык: Английский

---

Exploring the molecular mechanisms of curcumin in modulating memory impairment in neurodegenerative disorders

Molecular Biology Reports, Год журнала: 2024, Номер 52(1)

Опубликована: Дек. 9, 2024

Язык: Английский

---

Mechanism and Clinical Application Prospects of Mitochondrial DNA Single Nucleotide Polymorphism in Neurodegenerative Diseases

Neurochemical Research, Год журнала: 2024, Номер 50(1)

Опубликована: Дек. 14, 2024

Язык: Английский

---