Food Chemistry Advances, Год журнала: 2024, Номер 5, С. 100853 - 100853
Опубликована: Дек. 1, 2024
Язык: Английский
Processes, Год журнала: 2025, Номер 13(2), С. 350 - 350
Опубликована: Янв. 27, 2025
Puerarin (daidzein-8-C-glucoside), one of the bioactive isoflavones, has attracted attention in various industries due to its excellent pharmacological effects such as antioxidant effect, estrogen-like activity, reduction blood sugar, and neuroprotective effect. is most abundantly found roots Pueraria lobata (RPL) among biomass sources. To improve utilization feasibility puerarin, a high-yield extraction process should be designed for RPL. This study aimed optimize more efficiently recover puerarin from RPL while using generally recognized safe solvents solvents, considering potential industrial applications puerarin. The variables were optimized by one-factor-at-a-time method, response surface methodology, time profiling study. As result, yield was achieved at 60.56 mg/g under optimal conditions (ethanol concentration 46.06%, temperature 65.02 °C, ratio solvent 11.50 mL/g, 22 min). High this contributed improving applicability
Язык: Английский
Процитировано
1
Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107665 - 107665
Опубликована: Фев. 1, 2025
Quercetin, a prevalent natural flavonoid found in various medicinal plants, including Dendrobium officinale Kimura & Migo, has garnered attention for its potential health benefits. However, foundational animal studies investigating the effects of quercetin on lowering uric acid levels remain insufficiently established, and number related clinical is limited. This scarcity hinders practical application managing hyperuricemia. We systematically searched preclinical published by December 2024 nine databases, such as PubMed, Web Science, Embase. The results our meta-analysis showed that, compared with model group, not only effectively alleviated pathological injury kidney liver improved renal function indexes hyperuricemia but also played role modulating multiple signaling pathways oxidative stress, lipid metabolism, transporter proteins. Quercetin more substantial effect decreasing serum creatinine (SMD = -4.29, 95% CI [-6.48, -2.10], P 0.0001), blood urea nitrogen -3.08, [-4.80, -1.35], 0.0005), Up-regulate organic anion 1 mRNA expression 2.72, 95%CI [0.45, 4.99], 0.02) to positive control group. Sensitivity analyses confirmed stability results, while subgroup analysis indicates that treatment course may be main source heterogeneity. Dose-efficacy suggested had protective against at gavage dose 100 - 200mg/kg. accurately assess hyperuricemia, it essential conduct additional high-quality, large-scale trials validate findings.
Язык: Английский
Процитировано
1
Antioxidants, Год журнала: 2025, Номер 14(3), С. 259 - 259
Опубликована: Фев. 24, 2025
One of the major causes senescence is oxidative stress caused by ROS, which mainly generated from dysfunctional mitochondria. Strategies to limit mitochondrial ROS production are considered important for reversing senescence, but effective approaches reduce them have not yet been developed. In this study, we screened secondary metabolites that plants produce under and discovered sauchinone as a potential candidate. Sauchinone induced function recovery, enabling efficient electron transport within chain (ETC). This led decrease in production, byproduct inefficient transport. The reduction rejuvenated senescence-associated phenotypes. To understand underlying mechanism rejuvenates carried out RNA sequencing found VAMP8 key gene. was downregulated sauchinone. Knockdown decreased levels subsequently function, similar effect Taken together, these studies revealed novel reduces regulating expression. Our results open new avenue aging research control production.
Язык: Английский
Процитировано
1
Journal of Food Composition and Analysis, Год журнала: 2025, Номер unknown, С. 107372 - 107372
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Current Treatment Options in Oncology, Год журнала: 2025, Номер unknown
Опубликована: Март 22, 2025
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2024, Номер 29(23), С. 5556 - 5556
Опубликована: Ноя. 25, 2024
Kudzu, scientifically known as
Язык: Английский
Процитировано
0
Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 4
Опубликована: Дек. 26, 2024
Seventeen compounds were isolated from the aerial parts of Ceratocarpus arenarius L., including 1 previously undescribed xanthone and 6 firstly compounds. The structures identified by Mass spectrometry NMR spectroscopy. In addition, in vitro cytotoxicity isolates against human oesophageal squamous carcinoma KYSE-150 KYSE-70 cell investigated MTT to identify Genistein (8) 1,4-dihydroxy-2-naphthoic acid (9) as most effective compounds, which could exhibit anti-proliferation activity with IC50 values 39.11 μg/mL 5.71 KYSE-150, 34.07 4.51 KYSE-70, respectively. Swiss target prediction Molecular docking applied reveal action mechanism provide guidance for potential use C. L. antitumor treatment.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1464 - 1464
Опубликована: Ноя. 16, 2024
Zinc oxide nanobiocomposites were successfully synthesized using a green synthesis approach. The process involves the utilization of isoflavone puerarin, resulting in formation PUE-ZnO NPs.
Язык: Английский
Процитировано
0
Food Chemistry Advances, Год журнала: 2024, Номер 5, С. 100853 - 100853
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0