The Pharmaceutical and Pharmacological Potential Applications of Bilosomes as Nanocarriers for Drug Delivery
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1181 - 1181
Опубликована: Март 6, 2025
Nano-drug
delivery
systems
provide
targeted
solutions
for
addressing
various
drug
challenges,
leveraging
nanotechnology
to
enhance
solubility
and
permeability.
Liposomes,
explored
several
decades,
face
hurdles,
especially
in
oral
delivery.
Bile-acid
stabilized
vesicles
(bilosomes)
are
flexible
lipid
vesicles,
composed
of
phospholipids
or
other
surfactants,
along
with
amphiphilic
bile
salts,
they
show
superior
stability
pharmacokinetic
behavior
comparison
conventional
vesicular
(liposomes
niosomes).
Bilosomes
skin
penetration,
fluidize
the
stratum
corneum,
improve
stability.
In
applications,
bilosomes
overcome
drawbacks,
offering
improved
bioavailability,
controlled
release,
reduced
side
effects.
Vaccines
using
demonstrate
efficacy,
intranasal,
inhalation,
ocular,
buccal
applications
delivery,
targeted,
efficient,
activities.
Formulations
vary
based
on
active
substances
optimization
techniques,
showcasing
versatility
potential
across
diverse
routes.
Therefore,
aim
this
comprehensive
review
was
critically
explore
state-of-the-art
therapeutic
applications.
Язык: Английский
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Abstract
Intraoral
delivery
of
active
pharmaceutical
ingredients
(API)
is
an
attractive
approach
to
improve
their
local
therapeutic
efficacy
or
enable
systemic
delivery.
It
offers
several
advantages,
such
as
high
drug
concentration
at
the
intraoral
target
site
and
rapid
access
circulation
due
vascularization
oral
cavity,
bypassing
first‐pass
metabolism.
However,
limitations
need
be
addressed,
relatively
short
residence
time
formulations
applied
in
cavity
salivation,
swallowing
reflex,
tongue
movement,
well
poor
membrane
permeability
of,
particular,
hydrophilic
drugs.
Within
this
review,
a
comprehensive
summary
latest
strategies
formulation
approaches
field
provided,
focusing
on
those
pursued
by
academia
industry
overcome
challenges.
An
overview
provided
excipients
that
are
generally
recognized
safe
(GRAS)
utilized
enhance
systems,
mucoadhesive
materials,
enzyme
inhibitors,
permeation
enhancers.
Innovative
dosage
forms
outlined,
covering
solid,
semi‐solid,
liquid
systems
aerosols.
Future
trends,
including
self‐emulsifying
microneedles,
situ
bioprinting,
explored,
presenting
new
opportunities
for
Язык: Английский
Bioavailability Enhancement and Formulation Technologies of Oral Mucosal Dosage Forms: A Review
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 148 - 148
Опубликована: Янв. 22, 2025
The
oral
mucosa
is
a
versatile
surface
for
drug
administration,
supporting
both
local
and
systemic
therapies.
Many
active
substances
are
effectively
absorbed
in
the
cavity,
offering
an
alternative
to
enteral
administration
by
bypassing
harsh
gastrointestinal
environment
hepatic
first-pass
metabolism.
This
has
made
mucosal
delivery
growing
area
of
research.
Enhancing
bioavailability
ingredients
key
focus
pharmaceutical
technology,
especially
given
challenges
developing
new
drugs.
Numerous
strategies
improve
compatible
with
delivery,
unique
anatomy
cavity
enabling
specialized
applications.
A
variety
dosage
forms
tailored
meet
therapeutic
needs
while
addressing
biopharmaceutical
patient
compliance
challenges.
Proper
formulation
can
achieve
controlled
release,
improved
bioavailability,
convenience.
review
highlights
potential
focusing
on
enhancement
methods
types
production
technologies
optimized
use
cavity.
Язык: Английский
Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 195 - 195
Опубликована: Янв. 31, 2025
Drugs
administered
by
means
of
extravascular
routes
drug
administration
must
be
absorbed
into
the
systemic
circulation,
which
involves
movement
molecules
across
biological
barriers
such
as
epithelial
cells
that
cover
mucosal
surfaces
or
stratum
corneum
covers
skin.
Some
drugs
exhibit
poor
permeation
membranes
may
experience
excessive
degradation
during
first-pass
metabolism,
tends
to
limit
their
bioavailability.
Various
strategies
have
been
used
improve
Absorption
enhancement
include
co-administration
chemical
enhancers,
enzymes,
and/or
efflux
transporter
inhibitors,
changes,
and
specialized
dosage
form
designs.
Models
with
physiological
relevance
are
needed
evaluate
efficacy
absorption
techniques.
in
vitro
cell
culture
models
ex
vivo
tissue
explored
quantify
effectiveness
strategies.
This
review
deliberates
on
use
for
evaluation
selected
including
nasal,
oromucosal,
pulmonary,
oral,
rectal,
transdermal
administration.
Язык: Английский
Biomaterial-based Drug Delivery Strategies for Oral Mucosa
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
251, С. 114604 - 114604
Опубликована: Март 5, 2025
Язык: Английский
Novel Buccal Xanthan Gum–Hyaluronic Acid Eutectogels with Dual Anti-Inflammatory and Antimicrobial Properties
Gels,
Год журнала:
2025,
Номер
11(3), С. 208 - 208
Опубликована: Март 15, 2025
Buccal
drug
delivery
systems
often
struggle
with
poor
solubility,
limited
adhesion,
and
rapid
clearance,
leading
to
suboptimal
therapeutic
outcomes.
To
address
these
limitations,
we
developed
a
novel
hybrid
eutectogel
composed
of
xanthan
gum
(XTG),
hyaluronic
acid
(HA),
Natural
Deep
Eutectic
Solvent
(NADES)
system
(choline
chloride,
sorbitol,
glycerol
in
2:1:1
mole
ratio),
incorporating
2.5%
ibuprofen
(IBU)
as
model
drug.
The
formulation
was
optimized
using
face-centered
central
composite
design
enhance
the
rheological,
textural,
release
properties.
eutectogels
exhibited
shear-thinning
behavior
(flow
index,
n
=
0.26
±
0.01),
high
mucoadhesion
(adhesiveness:
2.297
0.142
N·s),
sustained
over
24
h,
governed
by
Higuchi
kinetics
(release
rate:
237.34
13.61
μg/cm2/min1/2).
ex
vivo
residence
time
increased
substantially
NADES
incorporation,
reaching
up
176.7
23.1
min.
An
anti-inflammatory
evaluation
showed
that
reduced
λ-carrageenan-induced
paw
edema
within
1
h
its
efficacy
kaolin
(p
<
0.05),
achieving
comparable
commercial
5%
IBU
gel,
despite
lower
concentration.
Additionally,
presented
minimum
inhibitory
concentration
for
Gram-positive
bacteria
25
mg/mL,
through
direct
contact,
it
microbial
viability
100%.
Its
against
Bacillus
cereus,
Enterococcus
faecium,
Klebsiella
pneumoniae,
combined
significant
properties,
positions
NADES-based
promising
multifunctional
platform
buccal
delivery,
particularly
inflammatory
conditions
complicated
bacterial
infections.
Язык: Английский
Development and Evaluation of Oromucosal Spray Formulation Containing Plant-Derived Compounds for the Treatment of Infectious and Inflammatory Diseases of the Oral Cavity
Yuliia Maslii,
Nataliia Herbina,
Lina Dėnė
и другие.
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2649 - 2649
Опубликована: Сен. 19, 2024
According
to
data
in
the
literature,
natural
products
and
essential
oils
are
often
used
dental
practice.
To
develop
a
new
oromucosal
spray
for
treatment
of
infectious
inflammatory
diseases
oral
cavity,
clove
CO2
extract
lavender
grapefruit
were
as
active
pharmaceutical
ingredients.
Clove
was
obtained
by
method
subcritical
extraction
from
various
raw
materials,
choice
which
based
on
yield
study
its
phytochemical
microbiological
properties.
Based
results
microscopic
diffraction
analyses,
rational
time
ultrasonic
exposure
emulsion
ingredients
established.
Mucoadhesive
polymers
stabilizers
two-phase
system
prolongators.
This
article
discusses
impact
type
concentration
mucoadhesive
stability
system;
viscous,
textural,
adhesive,
film
characteristics
spray;
parameters
determining
sprayability.
Язык: Английский
PİROKSİKAM DİLALTI POLİMERİK FİLMLERİNİN HAZIRLANMASI VE İN VİVO DEĞERLENDİRİLMESİ
Ankara Universitesi Eczacilik Fakultesi Dergisi,
Год журнала:
2024,
Номер
48(3), С. 34 - 34
Опубликована: Авг. 15, 2024
Amaç:
Farklı
ilaç
uygulamalarının
etken
maddelerin
etkinliğini
arttırabildiği
bilinmesine
rağmen
hangi
salım
sisteminin
daha
iyi
olduğu
konusunda
birçok
çalışma
bulunmaktadır.
Bunun
nedeninin
maddenin
özelliklerine
göre
bu
uygulamaların
büyük
avantaj
sağlamasıdır.
Bu
çalışmada
piroksikam
dilaltı
polimerik
film
uygulamasının
potansiyel
kullanımı
araştırılmıştır.
Gereç
ve
Yöntem:
Çalışmada
maltodekstrin
pullulan
içeren
filmler
hazırlanmış
sağlıklı
tavşan
in
vivo
modelinde
ilacın
plazma
düzeyleri
Sonuç
Tartışma:
İn
sonuçlar,
tek
doz
uygulamadan
sonra
10
saat
içinde
piroksikamın
en
yüksek
konsantrasyonlarına
ulaştığını
göstermiştir.
Ayrıca
profilinde
olası
gastrointestinal
emilime
karşılık
gelen
ikinci
bir
tepe
noktası
oluşmamıştır.
Özetle,
yüklü
analjezik
etkinin
sağlanması
amacıyla
kullanılabilir
özellikte
tespit
edilmiştir.