Extra Virgin Olive Oil and Metabolic Diseases
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8117 - 8117
Опубликована: Июль 25, 2024
Over
the
last
few
decades,
metabolic
syndrome
coexisting
with
cardiovascular
disease
has
evolved
into
a
pandemic,
making
need
for
more
food-oriented
therapeutic
approaches
and
redefinition
of
lifestyle
imperative,
Mediterranean
diet
being
linchpin
this
effort.
Extra
virgin
olive
oil
(EVOO),
key
pillar
one
most
notorious
edible
oils
worldwide,
owes
its
popularity
not
only
to
characteristic
aromas
taste
but
mainly
series
beneficial
health
attributes
including
anti-diabetic,
hypolipidemic,
anti-hypertensive
anti-obesity
actions.
In
narrative
review,
we
aimed
illustrate
enlighten
EVOO’s
properties
through
pathogenetic
approach,
investigating
potential
role
in
health.
Язык: Английский
Exploration of Early Diagnostic Biomarkers for Intestinal Barrier Dysfunction in Non-Alcoholic Fatty Liver Disease
Advances in Clinical Medicine,
Год журнала:
2025,
Номер
15(02), С. 315 - 321
Опубликована: Янв. 1, 2025
Язык: Английский
Grape pomace extract attenuates high fat diet-induced endotoxemia and liver steatosis in mice.
Food & Function,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Grape
pomace
extract
(GPE),
rich
in
bioactive
compounds,
protects
against
high-fat
diet-induced
obesity,
liver
damage,
inflammation
and
metabolic
disturbances,
part
by
preserving
intestinal
barrier
integrity
mitigating
endotoxemia.
Язык: Английский
Mitochondria at the Crossroads: Linking the Mediterranean Diet to Metabolic Health and Non-Pharmacological Approaches to NAFLD
Nutrients,
Год журнала:
2025,
Номер
17(7), С. 1214 - 1214
Опубликована: Март 30, 2025
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
growing
global
health
concern
that
closely
linked
to
metabolic
syndrome,
yet
no
approved
pharmacological
treatment
exists.
The
Mediterranean
diet
(MD)
emerged
as
first-line
dietary
intervention
for
NAFLD,
offering
and
hepatoprotective
benefits.
Now
conceptualized
complex
chemical
matrix
rich
in
bioactive
compounds,
the
MD
exerts
antioxidant
anti-inflammatory
effects,
improving
insulin
sensitivity
lipid
metabolism.
Mitochondria
play
central
role
NAFLD
pathophysiology,
influencing
energy
metabolism,
oxidative
stress,
homeostasis.
Emerging
evidence
suggests
MD's
compounds
enhance
mitochondrial
function
by
modulating
phosphorylation,
biogenesis,
mitophagy.
However,
most
research
has
focused
on
individual
rather
than
whole,
leaving
gaps
understanding
its
collective
impact
pattern.
This
narrative
review
explores
how
influence
highlighting
key
pathways
such
substrate
control,
dynamics,
efficiency.
A
literature
search
was
conducted
identify
relevant
studies
MD,
mitochondria,
NAFLD.
While
promising,
our
remains
incomplete,
particularly
when
current
knowledge
limited
lack
of
mechanistic
comprehensive
holistic
impact.
Future
integrating
cutting-edge
experimental
approaches
needed
elucidate
intricate
diet-mitochondria
interactions.
deeper
influences
essential
developing
precision-targeted
nutritional
strategies
can
effectively
prevent
manage
disease.
Язык: Английский
Anti-Diabetic Effects of Oleuropein
Metabolites,
Год журнала:
2024,
Номер
14(11), С. 581 - 581
Опубликована: Окт. 27, 2024
Background/Objectives:
Oleuropein,
a
secoiridoid
polyphenol
found
in
olive
oil
as
well
the
fruit
and
leaves
of
tree,
has
been
reported
to
have
antioxidant,
cardioprotective,
anti-inflammatory,
anti-cancer,
anti-diabetic
properties.
Type
2
diabetes
mellitus
(TD2M)
is
chronic
metabolic
disease
characterized
by
impaired
insulin
action,
termed
resistance.
The
development
T2DM
closely
associated
with
obesity
low-grade
inflammation.
In
recent
years,
rise
sedentary
lifestyles
diets
rich
refined
carbohydrates
saturated
fats
contributed
an
increase
prevalence
TD2M.
Currently,
strategies
for
treating
its
prevention
lack
efficacy
are
adverse
side
effects.
Hence,
there
urgent
need
novel
treatment
strategies,
including
naturally
occurring
compounds
possessing
hypoglycemic
insulin-sensitizing
Methods:
This
review
summarizes
evidence
anti-inflammatory
properties
oleuropein
from
vitro
vivo
animal
studies,
available
clinical
trials.
Results:
existing
indicates
that
may
exert
effects
downregulating
levels
pro-inflammatory
cytokines
hepatic
adipose
tissue.
Additionally,
suggests
targets
skeletal
muscle
enhances
glucose
uptake
related
protein
signalling
cascades,
improving
tolerance
sensitivity.
Conclusions:
Despite
oleuropein’s
potential,
more
studies
needed
proceed
towards
clinical/therapeutic
use
diseases
confidently.
Язык: Английский