Identification of pollutant markers in rural mountainous areas of China by combining non-targeted analysis with zebrafish embryo toxicity tests
The Science of The Total Environment,
Год журнала:
2025,
Номер
965, С. 178625 - 178625
Опубликована: Фев. 1, 2025
Язык: Английский
Special Issue “Antifungal Drug Discovery: Progresses, Challenges, Opportunities”
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2065 - 2065
Опубликована: Фев. 27, 2025
The
considerable
health
risks
associated
with
fungal
infections
are
continuously
rising,
thereby
requiring
proper
and
efficient
antifungal
treatment
options
[...].
Язык: Английский
Pharmacological Advances and Therapeutic Applications of Niclosamide in Cancer and Other Diseases
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown, С. 117527 - 117527
Опубликована: Март 1, 2025
Язык: Английский
Superior Anticancer and Antifungal Activities of New Sulfanyl-Substituted Niclosamide Derivatives
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1621 - 1621
Опубликована: Июль 21, 2024
The
approved
anthelmintic
salicylanilide
drug
niclosamide
has
shown
promising
anticancer
and
antimicrobial
activities.
In
this
study,
new
derivatives
with
trifluoromethyl,
trifluoromethylsulfanyl,
pentafluorosulfanyl
substituents
replacing
the
nitro
group
of
were
prepared
(including
ethanolamine
salts
two
salicylanilides)
tested
for
their
activities
against
esophageal
adenocarcinoma
(EAC)
cells.
addition,
antifungal
activity
a
panel
Язык: Английский
New Ground in Antifungal Discovery and Therapy for Invasive Fungal Infections: Innovations, Challenges, and Future Directions
Journal of Fungi,
Год журнала:
2024,
Номер
10(12), С. 871 - 871
Опубликована: Дек. 15, 2024
This
review
explores
current
advancements
and
challenges
in
antifungal
therapies
amid
rising
fungal
infections,
particularly
immunocompromised
patients.
We
detail
the
limitations
of
existing
classes—azoles,
echinocandins,
polyenes,
flucytosine—in
managing
systemic
infections
urgent
need
for
alternative
solutions.
With
increasing
incidence
resistance
pathogens,
such
as
Candida
auris
Aspergillus
fumigatus,
we
assess
emerging
agents,
including
Ibrexafungerp,
T-2307,
N′-Phenylhydrazides,
which
target
diverse
cell
mechanisms.
Innovations,
nanoparticles,
drug
repurposing,
natural
products,
are
also
evaluated
their
potential
to
improve
efficacy
reduce
resistance.
emphasize
importance
novel
approaches
address
growing
threat
posed
by
patients
with
limited
treatment
options.
Finally,
briefly
examine
use
artificial
intelligence
(AI)
development
new
treatments,
diagnoses,
prediction,
provides
powerful
tools
fight
against
pathogens.
Overall,
highlight
pressing
continued
research
advance
treatments
outcomes
high-risk
populations.
Язык: Английский
Repurposing Niclosamide for Treatment of Acute Myeloid Leukemia and Other Diseases
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Niclosamide
(NIC)
is
a
salicylanilide
that
was
developed
for
treatment
of
tapeworms
and
other
parasitic
infections.
The
mechanism
action
primarily
to
inhibit
oxidative
phosphorylation.
However,
more
recently,
additional
signaling
pathways
targets
have
been
identified.
Pre-clinical
studies
demonstrated
NIC
has
potential
effects
in
treating
infectious
diseases,
diabetic
kidney
disease,
cardiovascular
cancer.
This
chapter
summarizes
the
pharmacology
recent
pre-clinical
clinical
NIC.
Further
are
needed
determine
whether
can
be
repurposed
treat
acute
myeloid
leukemia,
prostate
cancer,
SARS-CoV-2,
hepatitis
E
virus,
rheumatoid
arthritis,
heart
failure.
Язык: Английский