Internal Medicine,
Год журнала:
2024,
Номер
21(4), С. 7 - 17
Опубликована: Дек. 1, 2024
Abstract
Modern
healthcare
emphasizes
the
importance
of
assessing
quality
life
in
patients
with
metabolic
syndrome
and
risk
sleep
apnea
using
validated
tools
such
as
SF-36
Short
Form.
Studies
reveal
a
high
prevalence
Romania,
rates
45%
women
44%
men,
its
frequent
association
due
to
shared
factors.
Research
findings
indicate
strong
connection
between
hypertension,
dyslipidemia,
insulin
resistance,
all
which
are
central
components
syndrome.
Furthermore,
exacerbates
cardiometabolic
complications
through
recurrent
episodes
hypopnea
apnea,
leading
fragmentation
intermittent
hypoxemia.
These
dysfunctions
trigger
cascades
hemodynamic,
autonomic,
inflammatory
responses,
increasing
risks
impairing
life.
The
objective
this
study
is
investigate
correlations
parameters
life,
offering
valuable
insights
into
mechanisms
linking
apnea.
Cells,
Год журнала:
2024,
Номер
13(16), С. 1349 - 1349
Опубликована: Авг. 14, 2024
Autism
spectrum
disorder
(ASD)
is
a
multifactorial
neurodevelopmental
condition
with
several
identified
risk
factors,
both
genetic
and
non-genetic.
Among
these,
prenatal
exposure
to
valproic
acid
(VPA)
has
been
extensively
associated
the
development
of
disorder.
The
zebrafish,
cost-
time-effective
model,
useful
for
studying
ASD
features.
Using
validated
VPA-induced
zebrafish
models,
we
aimed
provide
new
insights
into
VPA
effects
during
embryonic
identify
potential
biomarkers
ASD-like
Dose-response
analyses
were
performed
in
vivo
study
larval
phenotypes
mechanisms
underlying
neuroinflammation,
mitochondrial
dysfunction,
oxidative
stress,
microglial
cell
status,
motor
behaviour.
Wild-type
transgenic
Obesity,
a
rising
global
health
issue,
is
linked
to
numerous
disorders,
including
cognitive
impairment.
This
study
investigates
the
effects
of
coenzyme
Q10
(Co-Q10)
on
performance,
antioxidant
defense,
cholinergic
activity,
and
hippocampal
neuron
damage
in
rats
rendered
obese
by
monosodium
glutamate
(MSG)
exposure.
Forty-eight
neonatal
male
Wistar
were
randomly
assigned
one
four
groups:
Control,
MSG,
MSG
+
Q10-10,
Q10-20.
Monosodium
(4
g/kg
BW)
was
administered
subcutaneously
into
cervical
region
from
postnatal
day
(PND)
2
PND
10.
Coenzyme
(10
mg/kg
BW
20
intraperitoneally
30
42.
At
end
treatment
period,
working
memory
avoidance
learning
tests
conducted.
Anthropometric
data
collected,
followed
evaluations
catalase
(CAT),
superoxide
dismutase
(SOD),
acetylcholinesterase
(AChE),
glutathione
peroxidase
(GPx),
malondialdehyde
(MDA)
levels.
The
density
apoptotic/dark
neurons
(DN)
CA₁
CA₃
regions
hippocampus
also
assessed.
increased
Body
Mass
Index
(BMI)
Lee
Index,
impaired
learning,
reduced
CAT,
SOD,
GPx
activities.
Additionally,
exposure
led
elevated
MDA
levels,
AChE
higher
DN
regions.
Treatment
with
Co-Q10
resulted
decrease
BMI,
enhanced
noteworthy
increases
activities
hippocampus,
reductions
mitigates
neuronal
improves
function
MSG-induced
obesity,
primarily
through
its
inhibitory
properties.
Molecules,
Год журнала:
2025,
Номер
30(4), С. 877 - 877
Опубликована: Фев. 14, 2025
Neurodegenerative
diseases
such
as
Alzheimer's
and
Parkinson's
are
among
the
leading
causes
of
physical
cognitive
disability
across
globe.
Fifty
million
people
worldwide
suffer
these
diseases,
that
number
is
expected
to
rise
population
ages.
Ictus
another
pathology
also
courses
with
neurodegeneration
a
cause
mortality
long-term
in
developed
countries.
Schizophrenia
not
common
other
mental
disorders,
affecting
approximately
24
worldwide.
All
disorders
have
still
there
an
effective
pharmacological
treatment
cure
them.
The
N-methyl-D-aspartate
(NMDA)
receptor
(NMDAR)
has
attracted
attention
potential
therapeutic
target
due
its
important
role
learning
memory
implication
excitotoxicity
processes.
Some
drugs
targeting
NMDARs
already
being
used
treat
symptoms
central
nervous
system
(CNS).
Here,
we
aim
review
implications
NMDAR
CNS
pathologies,
target,
future
perspectives
for
developing
new
treatments
focused
on
receptors.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(4), С. 1337 - 1337
Опубликована: Фев. 18, 2025
Introduction:
Substance
use
disorder
(SUD)
is
a
significant
global
clinical
issue
marked
by
the
excessive
consumption
of
alcohol,
nicotine,
and
various
psychoactive
substances,
leading
to
impaired
social,
cognitive,
occupational
functioning.
Individuals
with
SUD
frequently
experience
depression
anxiety
disorders,
which
exacerbate
their
prognosis
contribute
substantial
health
social
burdens.
The
pathophysiology
its
associated
conditions
multifaceted,
involving
multiple
dysfunctions
in
brain.
This
complexity
underscores
an
urgent
need
for
development
noninvasive
treatments
that
can
directly
target
One
them
transcranial
direct
current
stimulation
(tDCS),
intensively
studied
technique
safely
modulating
cortical
excitability.
aim
this
study
investigate
effectiveness
tDCS
treating
symptoms
SUD.
Methods:
With
emphasis
on
underlying
mechanisms
action,
mechanistic
review
investigates
patients.
Literature
searches
were
conducted
using
PubMed/Medline,
ResearchGate,
Cochrane,
Google
Scholar
databases.
Results:
identified
12
relevant
studies.
results
showed
left
dorsolateral
prefrontal
cortex
(DLPFC)
effective
treatment
option
In
right
DLPFC
effective,
better
observed
stimulation.
However,
included
studies
differed
methodology,
sample
characteristics,
measurement
methods,
could
have
influenced
final
analysis.
central
focus
discuss
potential
action
These
include
modulation
brain
networks,
reduction
neuroinflammation,
enhancement
neuroplasticity,
increase
P300
amplitude.
We
also
limitations
propose
ways
address
future
research.
Conclusions:
provides
evidence
Stimulation
reduces
depression,
while
anxiety.
research
required
confirm
these
findings
deepen
our
understanding
through
exerts
effects
context.
Neuroimaging
methods
(fMRI
EEG)
blood
tests
be
particularly
useful.
Biomolecules,
Год журнала:
2025,
Номер
15(3), С. 404 - 404
Опубликована: Март 12, 2025
Aging
is
a
complex,
progressive,
and
irreversible
biological
process
that
entails
numerous
structural
functional
changes
in
the
organism.
These
affect
all
bodily
systems,
reducing
their
ability
to
respond
adapt
environment.
Chronic
inflammation
one
of
key
factors
driving
development
age-related
diseases,
ultimately
causing
substantial
decline
abilities
older
individuals.
This
persistent
inflammatory
state
(commonly
known
as
“inflammaging”)
characterized
by
elevated
levels
pro-inflammatory
cytokines,
an
increase
oxidative
stress,
perturbation
immune
homeostasis.
Several
factors,
including
cellular
senescence,
contribute
this
milieu,
thereby
amplifying
conditions
such
cardiovascular
disease,
neurodegeneration,
metabolic
disorders.
Exploring
mechanisms
chronic
aging
essential
for
developing
targeted
interventions
aimed
at
promoting
healthy
aging.
review
explains
strong
connection
between
inflammation,
highlighting
potential
therapeutic
approaches
like
pharmacological
treatments,
dietary
strategies,
lifestyle
changes.
