Journal of Enzyme Inhibition and Medicinal Chemistry, Год журнала: 2025, Номер 40(1)

Опубликована: Фев. 24, 2025

Hearing loss profoundly affects social engagement, mental health, cognition, and brain development, with sensorineural hearing (SNHL) being a major concern. Linked to ototoxic medications, ageing, noise exposure, SNHL presents significant treatment challenges, highlighting the need for effective prevention regeneration strategies. Ferroptosis, distinct form of cell death featuring iron-dependent lipid peroxidation, has garnered interest due its potential role in cancer, neuronal degeneration, especially loss. The emerging ferroptosis as crucial mediator suggests that it may offer novel therapeutic target otoprotection. This review aims summarise intricate connection between SNHL, offering fresh perspective exploring targeted strategies could potentially mitigate cochlear cells damage enhance quality life individuals impairments.

Язык: Английский