Reverse Gradient Distributions of Drug and Polymer Molecules within Electrospun Core–Shell Nanofibers for Sustained Release
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9524 - 9524
Опубликована: Сен. 1, 2024
Core–shell
nanostructures
are
powerful
platforms
for
the
development
of
novel
nanoscale
drug
delivery
systems
with
sustained
release
profiles.
Coaxial
electrospinning
is
facile
and
convenient
creating
medicated
core–shell
elaborate
designs
which
sustained-release
behaviors
molecules
can
be
intentionally
adjusted.
With
resveratrol
(RES)
as
a
model
poorly
water-soluble
cellulose
acetate
(CA)
PVP
polymeric
carriers,
brand-new
electrospun
nanostructure
was
fabricated
in
this
study.
The
guest
RES
host
CA
were
designed
to
have
reverse
gradient
distribution
within
nanostructures.
Scanning
electron
microscope
transmission
evaluations
verified
that
these
nanofibers
had
linear
morphologies,
without
beads
or
spindles,
an
obvious
double-chamber
structure.
X-ray
diffraction
patterns
Fourier
transform
infrared
spectroscopic
results
indicated
involved
components
highly
compatible
presented
amorphous
molecular
state.
In
vitro
dissolution
tests
new
structures
able
prevent
initial
burst
release,
extend
continuous-release
time
period,
reduce
negative
tailing-off
effect,
thus
ensuring
better
profile
than
traditional
blended
drug-loaded
nanofibers.
mechanism
underlying
influence
structure
RES/CA
on
proposed.
Based
proof-of-concept
demonstration,
series
advanced
functional
nanomaterials
similarly
developed
based
distributions
multi-chamber
Язык: Английский
Fenugreek seeds as a natural source of L-arginine-encapsulated lipid nanoparticles against diabetes
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 27, 2025
Diabetes,
affecting
over
10.5%
of
the
global
population,
leads
to
severe
health
complications
and
economic
burdens,
highlighting
urgent
need
for
effective
therapeutic
approaches.
Current
treatments
are
often
insufficient,
prompting
exploration
novel
agents
delivery
mechanisms.
This
study
addresses
this
gap
by
investigating
roles
L-arginine
(identified
as
a
target
drug
candidate
through
network
pharmacology)
in
diabetes
management,
while
also
evaluating
lipid
nanocarriers
synthesized
from
fenugreek
seed
oil
improved
delivery.
Our
docking
analyses
revealed
L-arginine's
strong
interactions
with
diabetes-target
genes
(CYP1A2,
CYP2C19,
NFKB),
multiple
hydrogen
bonds
binding
energies
ranging
−
7.2
8.9
kcal/mol.
Encapsulated
nanoparticles
were
characterized
using
UV-Visible
spectroscopy,
showing
absorbance
peaks
at
415
nm
simple
521
L-arginine-loaded
nanoparticles.
Scanning
electron
microscopy
confirmed
an
average
nanoparticle
size
100.2
nm,
zeta
potential
analysis
indicated
neutral
surface
charge
(−
9.37
mV).
Antioxidative
activity
showed
84.44%
inhibition
IC50
value
40.5
µg/mL
The
inhibited
albumin
denaturation
81.10%
alpha-amylase
89.30%,
surpassing
metformin
(78.43%
1000
µg/mL).
Hemolysis
percentage
was
minimal
10.54%.
These
findings
demonstrate
anti-diabetic
agent
highlight
efficacy
innovative
systems,
providing
foundation
advancing
interventions
against
diabetes.
Язык: Английский
A Comprehensive Review of Medicinal Plants with Antidiabetic Potential
Hacettepe University Journal of the Faculty of Pharmacy,
Год журнала:
2025,
Номер
45(1), С. 79 - 91
Опубликована: Март 1, 2025
Diabetes
is
one
of
the
most
common
chronic
diseases
and
its
incidence
prevalence
have
been
increasing
in
recent
years.
Moreover,
many
comorbidities
can
be
observed
addition
to
diabetes.
For
this
reason,
medicinal
plants
an
important
complementary
treatment
option
for
individuals
with
diabetes
from
past
present.
However,
as
every
disease,
correct
use
important.
Failure
do
so
may
worsen
course
cause
side/adverse
effects
lead
herb-drug
interactions.
This
review
aimed
identify
antidiabetic
comprehensively
describe
commonly
used
ones
detail.
When
studies
literature
were
evaluated,
it
was
determined
that
present,
but
potential
mechanism
activity,
positive/negative
effects,
dosages,
plant-drug
interactions
them
not
fully
revealed.
Further
research
needed,
incorrect
unknowing
these
disease.
Язык: Английский
Characterization of bioactive compounds in fenugreek genotypes in varying environments: diosgenin, trigonelline, and 4-hydroxyisoleucine
Frontiers in Plant Science,
Год журнала:
2025,
Номер
16
Опубликована: Март 24, 2025
This
study
investigates
the
effects
of
irrigated
and
non-irrigated
conditions
on
bioactive
compound
content
in
fenugreek
(
Trigonella
foenum-graecum
)
across
31
diverse
genotypes
from
various
geographical
regions.
The
was
conducted
at
Atatürk
University
Research
Extension
Center,
Türkiye
(N
39°55’59.9”,
E
41°14’10.6”,
altitude
1789
m)
during
2021
2022
growing
seasons.
levels
diosgenin,
trigonelline,
4-hydroxyisoleucine
analyzed
under
were
found
to
be
significantly
influenced
by
genotype,
environment,
their
interaction
(Genotype
×
Environment),
with
a
highly
significant
effect
observed
p
<
0.001
level.
compounds
included
diosgenin
(0.50-0.93%),
trigonelline
(5.22-13.65
mg
g
-
¹),
(0.41-1.90%).
Notably,
such
as
Sivas/TR,
Amasya/TR,
Konya/TR
Samsun/TR
exhibited
higher
all
conditions,
while
Spain,
Malaysia,
France,
India
showed
irrigation.
Variability
observed,
some
showing
stability
different
environmental
conditions.
A
negative
correlation
between
fenugreek.
Furthermore,
Principal
Component
Analysis
(PCA)
cluster
analysis
effective
revealing
genetic
diversity,
morphological
differences,
genotype
adaptability.
findings
highlight
potential
for
selecting
superior
breeding
programs
focused
enhancing
yields,
especially
varying
irrigation
research
emphasizes
critical
role
factors
optimizing
production
health-benefiting
Язык: Английский
Optical and green catalytic properties of fenugreek water for diabetes and skincare treatments
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 25, 2025
Язык: Английский
Mass Spectrometric Based Metabolomics of the Saudi Cultivar of Fenugreek (Trigonella foenum-graecum L.): A Combined GC-MS, Antimicrobial and Computational Approach
Pharmaceuticals,
Год журнала:
2024,
Номер
17(12), С. 1733 - 1733
Опубликована: Дек. 21, 2024
Background
and
Objective:
In
Saudi
Arabia,
numerous
plant
species
with
promising
medicinal
properties
are
cultivated,
widely
traded,
commonly
utilized
in
traditional
medicine,
including
fenugreek
(Trigonella
foenum-graecum).
This
study
aimed
to
comprehensively
assess
the
phytochemical
composition
antimicrobial
potential
of
cultivar
using
an
integrative
approach
combining
vitro
silico
methodologies.
Methods:
A
comprehensive
investigation
was
conducted
on
ethanol
extract
seeds,
assessing
its
antibacterial,
antifungal,
properties.
Computational
modeling
employed
predict
pharmacokinetic
behavior
toxicity
identified
bioactive
compounds.
Results:
Qalitative
analysis
showed
presence
alkaloids,
tannins,
saponins,
glycosides,
flavonoids,
steroids,
while
terpenoids
were
notably
absent.
GC-MS
Trigonella
foenum-graecum
(fenugreek)
seeds
25
compounds,
Ethyl
methane
sulfonate
(12.41%)
being
predominant
component.
Other
key
compounds
included
n-Hexadecanoic
acid,
4-Butyl-2(4-nitrophenyl)-1,3-thiazole,
α-Tocopherol.
phytochemicals
supported
their
antioxidant,
neuroprotective
potential,
21
24
showing
strong
binding
targets
like
Tyrosyl-tRNA
Synthetase
(TyrRS)
Staphylococcus
aureus
(S.
aureus),
Aspartic
proteinase
from
Candida
albicans
(C.
albicans)
human
peroxiredoxin
5.
Pharmacokinetic
indicated
good
oral
bioavailability,
minimal
CYP
inhibition,
blood-brain
barrier
penetration,
suggesting
for
treating
neurodegenerative
diseases.
These
diosgenin
trigonelline,
support
fenugreek’s
therapeutic
promise
warrant
further
vitro,
vivo,
clinical
studies.
Conclusion:
The
is
rich
antibacterial
potential.
findings
establish
a
robust
foundation
continued
pharmacological
research
T.
foenum-graecum,
highlighting
as
source
significant
value.
Язык: Английский
Active Ingredients and Antidiabetic Activity of Fenugreek: A Review Article
Saleh Ali Al-Qadoori,
F. Dawood,
Ali A. Al-fahham
и другие.
INTERNATIONAL JOURNAL OF HEALTH & MEDICAL RESEARCH,
Год журнала:
2024,
Номер
03(08)
Опубликована: Авг. 24, 2024
Fenugreek
(Trigonella
foenum-graecum)
is
a
plant
extensively
cultivated
in
Middle
Eastern
and
South
Asian
countries
where
its
seeds
have
been
traditionally
used
as
flavoring
agents
food
folk
medicine
for
variety
of
ailments,
including
diabetes.
Its
active
ingredients
include
proteins,
saponins,
polyphenols,
alkaloids,
flavonoids.
Extracts
were
found
rich
different
phytoconstituents,
such
trigonelline,
diosgenin,
4-hydroxyisoleucine,
3-hydroxyisoleucine,
fenugreekine,
which,
4-hydroxyisoleucine
saponins
focused
bioactive
molecules.
extracts
exhibit
antioxidant,
antidiabetic,
hepatoprotective,
antihyperlipidemic,
antimicrobial,
anti-inflammatory
activities.
Even
though
fenugreek
known
thrombolytic
action,
antidiabetic
hypocholesterolemic
effects
are
often
cited
most
important
therapeutic
effects.
Furthermore,
some
the
principles
hypoglycemic
activity
characterized
reported.
The
present
article
aims
to
provide
an
overview
fenugreek.
Язык: Английский