Iron Trace Elements Concentration in PM10 and Alzheimer’s Disease in Lima, Peru: Ecological Study DOI Creative Commons
Diego Fano-Sizgorich, Cinthya Vásquez‐Velásquez, Carol Ordóñez-Aquino

и другие.

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2043 - 2043

Опубликована: Сен. 8, 2024

Alzheimer’s disease (AD) has been linked to air pollution, especially particulate matter (PM). PM comprises various elements, including iron-rich particles that may reach the brain through inhalation. Lima, Peru is one of most polluted cities in Latin America, with a high rate AD. The study aims evaluate association between iron (Fe) trace elements PM10 and AD cases Peru. This retrospective ecological used monthly Fe concentration data from Peruvian Ministry Health. (ICD-10-G30) dementia (DAD, ICD-10-F00) were obtained CDC. element available for six districts Lima years 2017–2019 2022. Cases standardized based on ≥60-year-old populations each district. Hierarchical mixed-effects models Gaussian negative binomial families constructed both outcomes jointly (AD + DAD) separately (AD, DAD). A sensitivity analysis was conducted by excluding Lima’s downtown In complete model, log-Fe associated higher DAD DAD, IRR three outcomes. After controlling other metals, observed (β-coeff = 6.76, 95%CI 0.07; 13.46, p 0.048), (1.55, 1.09; 2.20, 0.014) (1.83, 1.21; 2.78, 0.004). not significant analysis. conclusion, exposure inhalation be presence Lima.

Язык: Английский

The effects of weight training and Aklil-ol-Malek on histopathology and C-Reactive Protein, Nuclear Factor Erythroid-Derived 2-Like 2Beta-Site Amyloid Precursor Protein Cleaving Enzyme1 genes Expression in Alzheimer’s disease model rats DOI Creative Commons

Farah Nameni,

Mohammad Reza Amir Khan Dehkordi

Journal of Neurorestoratology, Год журнала: 2025, Номер unknown, С. 100206 - 100206

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Iron Trace Elements Concentration in PM10 and Alzheimer’s Disease in Lima, Peru: Ecological Study DOI Creative Commons
Diego Fano-Sizgorich, Cinthya Vásquez‐Velásquez, Carol Ordóñez-Aquino

и другие.

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2043 - 2043

Опубликована: Сен. 8, 2024

Alzheimer’s disease (AD) has been linked to air pollution, especially particulate matter (PM). PM comprises various elements, including iron-rich particles that may reach the brain through inhalation. Lima, Peru is one of most polluted cities in Latin America, with a high rate AD. The study aims evaluate association between iron (Fe) trace elements PM10 and AD cases Peru. This retrospective ecological used monthly Fe concentration data from Peruvian Ministry Health. (ICD-10-G30) dementia (DAD, ICD-10-F00) were obtained CDC. element available for six districts Lima years 2017–2019 2022. Cases standardized based on ≥60-year-old populations each district. Hierarchical mixed-effects models Gaussian negative binomial families constructed both outcomes jointly (AD + DAD) separately (AD, DAD). A sensitivity analysis was conducted by excluding Lima’s downtown In complete model, log-Fe associated higher DAD DAD, IRR three outcomes. After controlling other metals, observed (β-coeff = 6.76, 95%CI 0.07; 13.46, p 0.048), (1.55, 1.09; 2.20, 0.014) (1.83, 1.21; 2.78, 0.004). not significant analysis. conclusion, exposure inhalation be presence Lima.

Язык: Английский

Процитировано

0