Potential Use of Exosomal Non-Coding MicroRNAs in Leukemia Therapy: A Systematic Review DOI Open Access
Paulina Gil-Kulik, Natalia Kluz, Dominika Przywara

и другие.

Cancers, Год журнала: 2024, Номер 16(23), С. 3948 - 3948

Опубликована: Ноя. 25, 2024

Leukemia is a heterogeneous group of hematological malignancies. Despite the enormous progress that has been made in field hemato-oncology recent years, there are still many problems related to, among others, disease recurrence and drug resistance, which why search for ideal biomarkers with high clinical utility continues. Research shows exosomes play critical role biology leukemia associated metastasis, immune status leukemias. Exosomes their cargo non-coding RNAs act as kind intermediary intercellular communication and, at same time, have ability to manipulate cell microenvironment influence reaction, proliferative, angiogenic, migratory properties cells. Exosomal ncRNAs (in particular, circRNAs microRNAs) appear be promising cell-free diagnostic, prognostic, treatment monitoring This review examines expression exosomal leukemias potential regulatory therapy but also conditions such relapse, status. Given key regulating gene networks intracellular pathways through interact DNA, transcripts, proteins identifying specific target genes, defining functions therapeutic strategies will provide valuable information.

Язык: Английский

Exosome-based miRNA delivery: Transforming cancer treatment with mesenchymal stem cells DOI Creative Commons
Ashok Kumar Balaraman, M. Arockia Babu, Muhammad Afzal

и другие.

Regenerative Therapy, Год журнала: 2025, Номер 28, С. 558 - 572

Опубликована: Фев. 13, 2025

Язык: Английский

Процитировано

0
MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance DOI
Ahsas Goyal, Muhammad Afzal,

Kavita Goyal

и другие.

Regenerative Therapy, Год журнала: 2025, Номер 29, С. 303 - 318

Опубликована: Апрель 5, 2025

Язык: Английский

Процитировано

0
Atg5-deficient mesenchymal stem cells protect against non-alcoholic fatty liver by accelerating hepatocyte growth factor secretion DOI Creative Commons

Caifeng Zhang,

Juanjuan Ji,

Xue-Fang Du

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Дек. 3, 2024

Mesenchymal stem cells (MSCs) have shown promising therapeutic potential in treating liver diseases, such as non-alcoholic fatty disease (NAFLD). Genetic modification has been employed to enhance the characteristics of MSCs for more effective treatment. Here, we present findings on human adipose-derived with Atg5 deficiency, investigating their impact and associated mechanisms NAFLD. In vitro, lentiviral transduction was downregulate or HGF using short hairpin RNA (shRNA). Subsequently, experiments were conducted evaluate cell senescence, proliferation, cycle, apoptosis, other pertinent aspects. vivo, a mouse model established by feeding them high-fat diet (HFD), effects transplantation assessed through serological, biochemical, pathological analyses. Our research indicate that Atg5-deficient display heightened proliferative activity. Subsequent co-culturing hepatocytes into NAFLD models demonstrated ability effectively reduce lipid accumulation modulating AMPKα/mTOR/S6K/Srebp1 pathway. Furthermore, observed deficiency enhances secretion hepatocyte growth factor (HGF) promoting recycling endosome (RE) production. Lastly, our study revealed 3-MA-primed can improve boosting HGF. suggest protect against accelerating secretion. This indicates gene-modified may represent strategy

Язык: Английский

Процитировано

1
Potential Use of Exosomal Non-Coding MicroRNAs in Leukemia Therapy: A Systematic Review DOI Open Access
Paulina Gil-Kulik, Natalia Kluz, Dominika Przywara

и другие.

Cancers, Год журнала: 2024, Номер 16(23), С. 3948 - 3948

Опубликована: Ноя. 25, 2024

Leukemia is a heterogeneous group of hematological malignancies. Despite the enormous progress that has been made in field hemato-oncology recent years, there are still many problems related to, among others, disease recurrence and drug resistance, which why search for ideal biomarkers with high clinical utility continues. Research shows exosomes play critical role biology leukemia associated metastasis, immune status leukemias. Exosomes their cargo non-coding RNAs act as kind intermediary intercellular communication and, at same time, have ability to manipulate cell microenvironment influence reaction, proliferative, angiogenic, migratory properties cells. Exosomal ncRNAs (in particular, circRNAs microRNAs) appear be promising cell-free diagnostic, prognostic, treatment monitoring This review examines expression exosomal leukemias potential regulatory therapy but also conditions such relapse, status. Given key regulating gene networks intracellular pathways through interact DNA, transcripts, proteins identifying specific target genes, defining functions therapeutic strategies will provide valuable information.

Язык: Английский

Процитировано

0