International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 189 - 189
Опубликована: Дек. 29, 2024
Extracellular
vesicles
(EVs)
are
a
heterogeneous
group
of
membrane-encapsulated
released
by
cells
into
the
extracellular
space.
They
play
crucial
role
in
intercellular
communication
transporting
bioactive
molecules
such
as
proteins,
lipids,
and
nucleic
acids.
EVs
can
be
detected
body
fluids,
including
blood
plasma,
urine,
saliva,
amniotic
fluid,
breast
milk,
pleural
ascites.
The
complexity
diversity
require
robust
standardized
approach.
By
adhering
to
protocols
guidelines,
researchers
ensure
consistency,
purity,
reproducibility
isolated
EVs,
facilitating
their
use
diagnostics,
therapies,
research.
Exosomes
microvesicles
represent
an
exciting
frontier
modern
medicine,
with
significant
potential
transform
diagnosis
treatment
various
diseases
important
personalized
medicine
precision
therapy.
primary
objective
this
review
is
provide
updated
analysis
significance
highlighting
mechanisms
action
exploring
applications
diseases.
Additionally,
addresses
existing
limitations
future
offering
practical
recommendations
resolve
current
challenges
enhance
viability
for
clinical
use.
This
comprehensive
approach
aims
bridge
gap
between
EV
research
its
application
healthcare.
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 10068 - 10068
Опубликована: Сен. 19, 2024
The
emerging
role
of
extracellular
vesicles
(EVs)
in
central
nervous
system
(CNS)
diseases
is
gaining
significant
interest,
particularly
their
applications
as
diagnostic
biomarkers
and
therapeutic
agents.
EVs
are
involved
intercellular
communication
secreted
by
all
cell
types.
They
contain
specific
markers
a
diverse
cargo
such
proteins,
lipids,
nucleic
acids,
reflecting
the
physiological
pathological
state
originating
cells.
Their
reduced
immunogenicity
ability
to
cross
blood-brain
barrier
make
them
promising
candidates
for
both
In
context
CNS
diseases,
have
shown
promise
isolable
from
different
body
fluids,
providing
non-invasive
method
diagnosing
monitoring
disease
progression.
This
makes
useful
early
detection
Alzheimer's,
Parkinson's,
amyotrophic
lateral
sclerosis,
where
alterations
content
can
be
detected.
Additionally,
derived
stem
cells
show
potential
promoting
tissue
regeneration
repairing
damaged
tissues.
An
evaluation
has
been
conducted
on
current
clinical
trials
studying
focusing
application,
treatment
protocols,
obtained
results.
review
aims
explore
carriers
highlighting
advantages
ongoing
evaluating
efficacy.
Cosmetics,
Год журнала:
2025,
Номер
12(1), С. 9 - 9
Опубликована: Янв. 13, 2025
This
study
addresses
a
significant
gap
in
the
clinical
validation
and
standardization
of
exosome-based
applications
within
domains
cosmetics
regenerative
medicine.
Despite
offering
thorough
overview
potential
therapeutic
benefits
underlying
mechanisms
exosomes,
manuscript
underscores
several
unresolved
challenges,
including
paucity
evidence,
regulatory
barriers,
inconsistencies
standardization,
incomplete
mechanistic
understanding.
The
primary
aim
this
research
is
to
conduct
systematic
comprehensive
review
existing
studies
on
exosomes
skincare.
To
achieve
this,
literature
was
performed,
drawing
major
medical
database
PubMed.
approach
facilitated
collection
meta-analysis
relevant
data,
ensuring
rigorous
assessment
recent
advancements
exosome
research.
main
outcomes
highlight
multifaceted
roles
promoting
skin
rejuvenation
mitigating
signs
aging.
Specific
discussed
include
pigmentation
correction,
wound
healing,
tissue
repair,
innovative
delivery
mechanisms.
Moreover,
examines
emerging
plastic
surgery
Challenges
limitations,
such
as
constraints,
hurdles,
need
for
further
validation,
are
critically
analyzed,
providing
framework
future
directions.
Biomaterials Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
schematic
demonstrates
MSC
seeded-Chitosan-Collagen-Fibrinogen-D3(CCF-D3)
scaffold
with
HADF
seeded-dextran
beads-coculture
for
vascular
sprouting
via
VEGF-associated
pathway
and
inhibited
by
100
μM
dexamethasone,
exosomal
spectra
analysis.
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 11, 2025
The
self-renewal
ability
and
multipotency
of
stem
cells
give
them
great
potential
for
use
in
wound
healing.
Stem
cell-derived
exosomes,
owing
to
their
close
biological
resemblance
parent
cells,
offer
a
more
efficient,
safer,
economical
approach
facilitating
cellular
communication
interactions
within
different
environments.
This
makes
particularly
valuable
the
treatment
both
acute
chronic
wounds,
such
as
lacerations,
burns,
diabetic
ulcers.
Long
non-coding
RNAs
(lncRNAs)
enclosed
one
leading
actors
these
extracellular
microvesicles,
through
interaction
with
miRNAs
regulation
various
signaling
pathways
involved
inflammation,
angiogenesis,
cell
proliferation,
migration,
could
heal
wounds.
Exosome-derived
lncRNAs
from
facilitate
matrix
remodeling
between
macrophages
fibroblasts.
Moreover,
alongside
regulating
expression
inflammatory
cytokines,
controlling
reactive
oxygen
species
levels,
enhancing
autophagic
activity,
they
also
modulate
immune
responses
support
Regulating
genes
related
by
increasing
blood
supply
accelerating
delivery
essential
substances
environment,
is
another
effect
exosomal
derived
These
can
enhance
skin
healing
homeostasis,
proliferation
differentiation
wound-healing
process,
fibroblast
viability
migration
injury
site.
Ultimately,
exosome-derived
novel
insights
into
molecular
mechanisms
underlying
improved
They
pave
way
therapeutic
strategies,
fostering
further
research
better
future.
Meanwhile,
exosomes
mesenchymal
due
exceptional
regenerative
properties,
well
have
emerged
innovative
tools
review
article
aims
narrate
roles
focus
on
cells.
