PKN2 enhances the immunosuppressive activity of polymorphonuclear myeloid-derived suppressor cells in esophageal carcinoma by mediating fatty acid oxidation

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Март 11, 2025

Abstract Background Myeloid-derived suppressor cells (MDSCs) in tumor microenvironment reduce the efficacy of immunotherapy. PKN2 plays a role colon cancer, but its function esophageal cancer (EC) remains unclear. This study investigated expression MDSCs derived from EC tissues and determined whether regulates immunosuppressive activity by mediating fatty acid oxidation (FAO). Materials methods was GEO database, patients, 4-NQO-induced mice, as well different types immune cells. The effect on polymorphonuclear myeloid-derived (PMN-MDSCs) co-culture PMN-MDSCs CD4 + /CD8 T patient-derived organoids autologous performed to observe PMN-MDSCs. Results is highly expressed compared normal tissues, especially tumor-infiltrated Overexpressing contributes vitro. PKN2-overexpressing inhibited killing ability cytotoxic lymphocytes promoted organoid growth. promotes FAO via CPT1B (a key enzyme FAO). Mechanistically, transcription upregulating STAT3 phosphorylation. Conclusions increased human mouse tissues. enhancing facilitating phosphorylation transcription, which turn leads CPT1B-mediated Targeted inhibition expected improve immunotherapeutic patients.

Язык: Английский

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Antioxidant activity of sinapic acid anilides: DPPH, ABTS, FRAP, electrochemical and theoretical analysis.

LWT, Год журнала: 2025, Номер unknown, С. 117656 - 117656

Опубликована: Март 1, 2025

Язык: Английский

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Onstruction and Security Performance Analysis of an Anti-Attack Optical Character Recognition (OCR) System

Опубликована: Дек. 20, 2024

Язык: Английский

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