Polyphenols from Edible Brown Seaweeds Against Adiposopathy-Associated Metabolic Ailments

Food Reviews International, Год журнала: 2025, Номер unknown, С. 1 - 28

Опубликована: Янв. 16, 2025

Adiposopathy principally characterized by adipocyte hypertrophy in visceral fat pads with excess triglyceride accumulation augments the sickening of tissue cells. Adipocyte is central precursor chronic-low grade/systemic inflammation and impaired lipid profile metabolically sick obese patients over healthy subjects. With these pathophysiology alterations, are susceptible to metabolic syndrome associated hyperglycemia, insulin resistance, dyslipidemia, hypertension, coronary artery atherosclerosis, endothelial dysfunction, cardiac failure, liver steatosis. Brown seaweeds enriched all essential nutrients, especially polyphenols, have been widely consumed as a staple diet. In-vitro in-vivo studies showed polyphenols derived from brown could reverse impairments via attenuating inflammation, systolic blood pressure, oxidative stress, resistance. However, human clinical trials remain inadequate witness therapeutic potential algal against syndrome, adiposopathy-linked syndrome. The article unveils efficacy crude or purified formulations their effective therapeutic-dose concentrations 2838 mg/day (crude)/85–177 (pure fractions) attenuate ailments unhealthy patients.

Язык: Английский

Protective Effects of Oral Pharmaceutical Solution of Fucoxanthin Against Paracetamol-Induced Liver Injury: Modulation of Drug-Metabolizing Enzymes, Oxidative Stress, and Apoptotic Pathways in Rats

Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Фев. 24, 2025

Paracetamol (PAC) overdose causes acute liver injury through oxidative stress, inflammation, and apoptosis. While N-acetyl cysteine (NAC) is the standard treatment, fucoxanthin (FUC), a carotenoid from brown seaweed, has shown hepatoprotective effects in animal studies, but its role PAC toxicity unclear. Compared to NAC, this study assessed potential of oral FUC solution towards PAC-induced rat's liver. was formulated as pharmaceutical characterized via UV-VIS spectroscopy. Six groups male Wistar rats each contain five which are total thirty rats: negative control (NC), positive (PC, 2 g/kg PAC), NAC (1200 mg/kg), three doses (100, 200, 500 mg/kg) for seven days, with administered on day-8. Liver tissues were analyzed gene expression, histology. clear absorbance at 433 nm. caused 30% mortality (p < 0.01 vs. others). reduced ALT (56%), AST (78%), ALP (28%), increased TP by 25% 0.001 PC). mg/kg (F500) superior, reducing (82%), (93%), (40%), increasing (35%) NAC). CYP2E1/CYP3A2 apoptosis markers, suppressed Nrf2/AMPK/AKT1. F500 improved antioxidants, apoptosis, enhanced Nrf2/AMPK pathway, downregulated 0.01). FUC, particularly mg/kg, offers significant hepatoprotection against modulating drug metabolizing enzymes enhancing antioxidant defences, warranting further research.

Язык: Английский

Therapeutic potential of plant polyphenols in acute pancreatitis

Inflammopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Язык: Английский