Multifaceted impact of HIV inhibitor dapivirine on triple negative breast cancer cells reveals potential entities as targets for novel therapy DOI Creative Commons
Ketki Patil, Elizabeth Johnston,

Joseph Novack

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 3, 2024

Breast cancer is the most common in women worldwide. Many breast cancers originate from cells lining milk duct and some become invasive. lacking estrogen, progesterone receptors (ER-, PR-) epidermal growth factor receptor 2 (HER2-) amplification, termed "Triple negative" (TNBC) reported to frequently affect Black younger women. TNBC an invasive ductal carcinoma with limited treatment options. To this end, we opted investigate drugs that could be repurposed because they offer advantages bringing effective treatments faster clinic. We chose study effect of drug, dapivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV it detected lactating when treated for drug potentially target cancer. Here show potent impact dapivirine on MDA-MB-231 cells, while NNRTI like nevirapine showed marginal effects. When was tested other cell lines, MCF-7 MCF 10A, inhibition at higher concentrations. Molecular studies revealed increase reactive oxygen species (ROS), apoptotic activation caspases. Importantly, protein profiling STRING analysis deregulation key molecule, PCNA pivotal signaling circuits including extracellular matrix (ECM), angiogenesis, adhesion, immunomodulation. Of note, its potential stem-like due downregulation basic transcription 3 (BTF3) proteasome activator complex subunit 3; latter affecting their dependence pathway. Taken together, exhibits considered as monotherapy/combination therapy. Notably, also individuals dual ailments, such TNBC, if clinical outcomes favorable.

Язык: Английский

Selenium and Selenoproteins: Mechanisms, Health Functions, and Emerging Applications DOI Creative Commons

Shahidin,

Yan Wang, Yi-Long Wu

и другие.

Molecules, Год журнала: 2025, Номер 30(3), С. 437 - 437

Опубликована: Янв. 21, 2025

Selenium (Se) is an essential trace element crucial for human health that primarily functions as immunonutrient. It incorporated into polypeptides such selenocysteine (SeC) and selenomethionine (SeMet), two key amino acids involved in various biochemical processes. All living organisms can convert inorganic Se biologically active organic forms, with SeMet being the predominant form a precursor SeC production humans animals. The genome encodes 25 selenoprotein genes, which incorporate low-molecular-weight compounds of SeC. Organic Se, especially selenoproteins, more efficiently absorbed than driving demand selenoprotein-based products, functional foods. Se-enriched foods offer practical means delivering bioavailable are associated enhanced antioxidant properties benefits. Recent advancements synthesis have improved our understanding their roles defense, cancer prevention, immune regulation, anti-inflammation, hypoglycemia, cardiovascular health, Alzheimer’s disease, fertility, COVID-19. This review highlights selenoproteins biological functions, biosynthetic pathways, emerging applications while highlighting need further research.

Язык: Английский

Процитировано

1
Role of the sulfur-containing amino acid-ROS axis in cancer chemotherapeutic drug resistance DOI
Bingli Wu, Yinwei Cheng, Liyan Li

и другие.

Drug Resistance Updates, Год журнала: 2025, Номер unknown, С. 101238 - 101238

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Roles of selenium-containing glutathione peroxidases and thioredoxin reductases in the regulation of processes associated with glioblastoma progression DOI
Е. Г. Варламова

Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер unknown, С. 110344 - 110344

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Composition, Properties, and Beneficial Effects of Functional Beverages on Human Health DOI Creative Commons

Andreas A. Panou,

Ioannis K. Karabagias

Beverages, Год журнала: 2025, Номер 11(2), С. 40 - 40

Опубликована: Март 14, 2025

Functional beverages comprise a special category of drinks free alcohol that contain bioactive components from plant, animal, marine, or microorganism sources contribute to the reinforcement human health. are mainly divided into following basic categories: (i) dairy-based and (ii) non-dairy-based beverages. have several positive functional properties such as rehydration body, recovery lost energy, increase athletic performance, prevention pain in joints, improvement heart health, immunity digestive system, creation feeling satiety boosting mood. However, according health experts, there also induce obesity diseases because their high content sugars, sweeteners, other caffeine, taurine, taurine combined with creatinine, etc. The scope this review was highlight main energy along effects on Limited articles address overall hypothesis recent literature, thus comprising significance current study.

Язык: Английский

Процитировано

0
Smart Drug Delivery Systems Based on Cyclodextrins and Chitosan for Cancer Therapy DOI Creative Commons

Larisa Păduraru,

Alina Diana Panainte, Cătălina A. Peptu

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 564 - 564

Опубликована: Апрель 13, 2025

Despite improvements in therapeutic approaches like immunotherapy and gene therapy, cancer still remains a serious threat to world health due its high incidence mortality rates. Limitations of conventional therapy include suboptimal targeting, multidrug resistance, systemic toxicity. A major challenge current oncology therapies is the development new delivery methods for antineoplastic drugs that act directly on target. One approach involves complexation antitumor with cyclodextrins (CDs) chitosan (CS) as an attempt counteract their primary limitations: low water solubility bioavailability, diminished vitro vivo stability, dose-dependent All those drawbacks may potentially exclude some candidates from clinical trials, thus integration into smart systems or drug-targeting technologies must be implemented. We intended overview drug based regard diagnosis management. This narrative review encompasses full-length articles published English between 2019 2025 (including online ahead print versions) PubMed-indexed journals, focusing recent research encapsulation diverse within nanosystems exhibit responsiveness various stimuli such pH, redox potential, folate receptor levels, thereby enhancing release bioactive compounds at tumor sites. The majority cited references focus most notable research, studies novel applications, scientific advancements field nanostructures functional materials employed oncological over last six years. Certainly, there are additional potential can facilitate drug’s upon activation, reactive oxygen species (ROS), enzymes, ATP level, hypoxia; however, our exclusively addresses aforementioned presented comprehensive manner.

Язык: Английский

Процитировано

0
Multifaceted impact of HIV inhibitor dapivirine on triple negative breast cancer cells reveals potential entities as targets for novel therapy DOI Creative Commons
Ketki Patil, Elizabeth Johnston,

Joseph Novack

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 3, 2024

Breast cancer is the most common in women worldwide. Many breast cancers originate from cells lining milk duct and some become invasive. lacking estrogen, progesterone receptors (ER-, PR-) epidermal growth factor receptor 2 (HER2-) amplification, termed "Triple negative" (TNBC) reported to frequently affect Black younger women. TNBC an invasive ductal carcinoma with limited treatment options. To this end, we opted investigate drugs that could be repurposed because they offer advantages bringing effective treatments faster clinic. We chose study effect of drug, dapivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV it detected lactating when treated for drug potentially target cancer. Here show potent impact dapivirine on MDA-MB-231 cells, while NNRTI like nevirapine showed marginal effects. When was tested other cell lines, MCF-7 MCF 10A, inhibition at higher concentrations. Molecular studies revealed increase reactive oxygen species (ROS), apoptotic activation caspases. Importantly, protein profiling STRING analysis deregulation key molecule, PCNA pivotal signaling circuits including extracellular matrix (ECM), angiogenesis, adhesion, immunomodulation. Of note, its potential stem-like due downregulation basic transcription 3 (BTF3) proteasome activator complex subunit 3; latter affecting their dependence pathway. Taken together, exhibits considered as monotherapy/combination therapy. Notably, also individuals dual ailments, such TNBC, if clinical outcomes favorable.

Язык: Английский

Процитировано

0