The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease
Biomolecules,
Год журнала:
2025,
Номер
15(3), С. 433 - 433
Опубликована: Март 18, 2025
Mitochondrial
dynamics,
governed
by
fusion
and
fission,
are
crucial
for
maintaining
cellular
homeostasis,
energy
production,
stress
adaptation.
MFN2
OPA1,
key
regulators
of
mitochondrial
fusion,
play
essential
roles
beyond
their
structural
functions,
influencing
bioenergetics,
intracellular
signaling,
quality
control
mechanisms
such
as
mitophagy.
Disruptions
in
these
processes,
often
caused
or
OPA1
mutations,
linked
to
neurodegenerative
diseases
like
Charcot-Marie-Tooth
disease
type
2A
(CMT2A)
autosomal
dominant
optic
atrophy
(ADOA).
This
review
explores
the
molecular
underlying
impact
dysfunction
on
oxidative
phosphorylation
autophagy,
role
progression.
Additionally,
we
discuss
divergent
responses
particularly
terms
proliferation,
senescence,
metabolic
signaling.
Finally,
highlight
emerging
therapeutic
strategies
restore
integrity,
including
mTOR
modulation
autophagy-targeted
approaches,
with
potential
implications
disorders.
Язык: Английский
Genetic and pharmacological correction of impaired mitophagy in retinal ganglion cells rescues glaucomatous neurodegeneration
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 15, 2025
Progressive
loss
of
retinal
ganglion
cells
(RGCs)
and
degeneration
optic
nerve
axons
are
the
pathological
hallmarks
glaucoma.
Ocular
hypertension
(OHT)
mitochondrial
dysfunction
linked
to
neurodegeneration
vision
in
However,
exact
mechanism
leading
glaucomatous
is
poorly
understood.
Using
multiple
mouse
models
OHT
human
eyes
from
normal
glaucoma
donors,
we
show
that
induces
impaired
mitophagy
RGCs,
resulting
accumulation
dysfunctional
mitochondria
contributing
neurodegeneration.
reporter
mice,
precedes
Notably,
pharmacological
rescue
via
Torin-2
or
genetic
upregulation
RGC-specific
Parkin
expression
restores
structural
functional
integrity
RGCs
their
ex-vivo
retinal-explant
cultures.
Our
study
indicates
contributes
oxidative
stress,
Enhancing
represents
a
promising
therapeutic
strategy
prevent
Язык: Английский
Potential Risks of Ocular Molecular and Cellular Changes in Spaceflight
Seminars in Ophthalmology,
Год журнала:
2025,
Номер
unknown, С. 1 - 11
Опубликована: Март 17, 2025
Purpose
Many
fundamental
cellular
and
molecular
changes
are
known
to
occur
in
biological
systems
during
spaceflight,
including
oxidative
stress,
DNA
damage,
mitochondrial
epigenetic
factors,
telomere
lengthening,
microbial
shifts.
We
can
apply
the
consequences
of
these
ocular
cells,
such
as
retinal
ganglion
cells
corneal
epithelium,
identify
ophthalmologic
risks
spaceflight.
This
review
aims
discuss
potential
greater
detail
principles
ophthalmic
disease
risk
astronauts.
Язык: Английский