Neurological disability and brain grey matter atrophy in primary progressive multiple sclerosis are determined by microstructural lesional changes, but not by lesion load

Journal of Neurology, Год журнала: 2025, Номер 272(4)

Опубликована: Апрель 1, 2025

Conventional MRI measures, such as the number and volume of MS lesions, are histologically non-specific cannot sufficiently explain clinical disability or brain atrophy in MS. Nevertheless, demyelinating plaques exhibit distinct histopathological features relapsing progressive multiple sclerosis (MS) subtypes. The aim this study was to assess microstructural characteristics lesions using quantitative explore their associations with grey matter (GM) disability. 56 control subjects (CS), 121 patients relapsing-remitting (RRMS), 38 primary (PPMS) underwent 1.5 T scans examinations. Lesion segmentation based on T1-weighted FLAIR images were performed SAMSEG. MDME sequence SyMRI software used estimate relaxation rates myelin fraction normal-appearing white (NAWM). Associations between lesional NAWM parameters GM investigated. Brain regional volumes significantly decreased PPMS compared those RRMS. Quantitative demonstrated statistically significant cortical deep well scores RRMS especially PPMS. In contrast RRMS, lesion not associated either group. but load, strongly patients, likely reflecting differences pathology

Язык: Английский

Epigenetic and Mitochondrial Metabolic Dysfunction in Multiple Sclerosis: A Review of Herbal Drug Approaches and Current Clinical Trials

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Язык: Английский