Oleoylethanolamide effects on stress-induced ethanol consumption: A lipid at the crossroads between stress, reward and neuroinflammation DOI Creative Commons

Sandra Montagud-Romero,

Macarena González-Portilla,

Susana Mellado

и другие.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111365 - 111365

Опубликована: Апрель 1, 2025

The endocannabinoid system is involved in multiple drug-related behaviors and the transient increase endogenous cannabinoids endocannabinoid-like molecules contributes to healthy adaptation stress exposure. Oleoylethanolamide (OEA) belongs N-acylethanolamines interacts with system. In this study, we investigated effect of systemic OEA treatment (10 mg/kg), before or after social defeat (SD), on ethanol self-administration (SA). Mice were divided into non-stressed (EXP) stressed (SD) groups randomly assigned a condition (control-CTRL, 10OEA). EXP/SD-OEA group mice received four doses each SD encounter, while EXP/SD-10OEA daily dose for 10 consecutive days following Three weeks SD, trained self-administer 20 % (vol/vol) solution. Upon extinction, cue-induced reinstatement test was performed. Our results showed that both treatments effectively prevented stress-induced consumption observed defeated mice. No significant effects relapse-like behavior observed. Additionally, found animals exposed during encounters reduced nuclear factor kappa B (NF-κB) levels, suggesting an anti-inflammatory OEA, tumor necrosis (TNFα) gene expression decreased animals. summary, these findings suggest exogenously increasing levels counteracts adverse drinking having some impact inflammatory patterns.

Язык: Английский

Oleoylethanolamide effects on stress-induced ethanol consumption: A lipid at the crossroads between stress, reward and neuroinflammation DOI Creative Commons

Sandra Montagud-Romero,

Macarena González-Portilla,

Susana Mellado

и другие.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111365 - 111365

Опубликована: Апрель 1, 2025

The endocannabinoid system is involved in multiple drug-related behaviors and the transient increase endogenous cannabinoids endocannabinoid-like molecules contributes to healthy adaptation stress exposure. Oleoylethanolamide (OEA) belongs N-acylethanolamines interacts with system. In this study, we investigated effect of systemic OEA treatment (10 mg/kg), before or after social defeat (SD), on ethanol self-administration (SA). Mice were divided into non-stressed (EXP) stressed (SD) groups randomly assigned a condition (control-CTRL, 10OEA). EXP/SD-OEA group mice received four doses each SD encounter, while EXP/SD-10OEA daily dose for 10 consecutive days following Three weeks SD, trained self-administer 20 % (vol/vol) solution. Upon extinction, cue-induced reinstatement test was performed. Our results showed that both treatments effectively prevented stress-induced consumption observed defeated mice. No significant effects relapse-like behavior observed. Additionally, found animals exposed during encounters reduced nuclear factor kappa B (NF-κB) levels, suggesting an anti-inflammatory OEA, tumor necrosis (TNFα) gene expression decreased animals. summary, these findings suggest exogenously increasing levels counteracts adverse drinking having some impact inflammatory patterns.

Язык: Английский

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