Biomedicine, Год журнала: 2024, Номер 14(4)
Опубликована: Дек. 1, 2024
Introduction: In recent years, significant progress has been made in regenerative medicine, specifically using mesenchymal stem cells (MSCs) due to their and differentiating abilities. An exciting development this area is the utilization of exosomes derived from MSCs, which have shown promise tissue restoration, immune system modulation, cancer treatment.
Язык: Английский
Life Sciences, Год журнала: 2025, Номер 368, С. 123499 - 123499
Опубликована: Фев. 22, 2025
Язык: Английский
Процитировано
1
Опубликована: Янв. 1, 2025
Процитировано
0
Cells, Год журнала: 2025, Номер 14(5), С. 323 - 323
Опубликована: Фев. 20, 2025
Osteoarthritis (OA) is one of the most common degenerative diseases in dogs and humans, which can lead to articular cartilage deterioration, chronic pain, decreased quality life. The anti-inflammatory, anti-fibrotic, analgesic, regeneration properties mesenchymal stem cell (MSC) therapy provide a new direction for treatment development OA future. Currently, MSC lacks confirmed ideal sources, dosages, formulations, specific characteristics. In this study, we evaluated efficacy multiple canine adipose-derived (ADSC) injections on anti-inflammation joint damage model. Considering animal ethics, simulated effects inflammation repair during through mouse model, detection inflammation-related key factors via histology molecular biology, it was found that has certain effect cartilage, but anti-inflammatory time-dependent. verified feasibility ADSCs. Compared with control group, group obvious, inflammatory decreased, showing an obvious therapeutic effect. This study demonstrates intra-articular ADSCs could be effective treating symptoms.
Язык: Английский
Процитировано
0
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Март 17, 2025
Bone defect, a common orthopedic condition, is characterized by lengthy and impactful treatment period, posing considerable challenge in clinical settings. Medical technology has advanced notably, effectively treated an increasing number of patients with bone defects. Consequently, there been explosion research articles on regeneration, including substantial the application exosomes. Exosomes, especially those derived from stem cells, have confirmed to be effective regeneration garnered widespread attention last decade. Therefore, this study conducted bibliometric analysis publications related exosomes for regeneration. The objectives are explore development history hotspots field over past 10 years, predict future trends, provide guidance subsequent research. Web Science Core Collection (WoSCC) database was searched published 1 January 2014, 31 December 2023. collected literature analyzed using software such as Microsoft Excel, CiteSpace 6.3R1, VOSviewer 1.6.20, online platform (https://bibliometric.com). A total 3,004 2,729 institutions 68 countries were included study. increased annually China most prolific country field, 1,468 papers; Shanghai Jiao Tong University (China) institution highest (117 publications). In terms authors, Xin Wang, Yi Zhang, Yang Wang three who papers, 14 papers each. Co-citation revealed that article Valadi H 2007 co-citations (270 times quotation). Additionally, focused function mechanism action. Furthermore, importance osteoblast differentiation angiogenesis also significant scholars field. This reviewed achievements utilizing tools. It visualized countries, institutions, journals made contributions current hotspots, finally explored trends.
Язык: Английский
Процитировано
0
Опубликована: Март 29, 2025
Osteoarthritis is a degenerative disease of the cartilage that affects millions. Its pathology characterized by catabolic and anabolic factors can be modified due to age, weight genetics increase severity deterioration. Current standards care may manage symptoms, but there currently no proven treatment osteoarthritis reverse degeneration build back ECM. Due this, stem cells have been investigated as potential therapy. This because their unique abilities differentiate into many cell types even regenerate tissue. Mesenchymal targeted specifically high reproduction rate other important factors. Studies done concluded are statistically significant benefits in treating osteoarthritic joints with mesenchymal derived from adipose tissue umbilical cord well synovial. Although these recorded, it still imperative further studies conducted test longevity its possible negative side effects.
Язык: Английский
Процитировано
0
Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)
Опубликована: Апрель 17, 2025
Small extracellular vesicles (sEVs) are membrane-bound with a size of less than 200 nm, released by cells. Due to their relatively small molecular weight and ability participate in intercellular communication, sEVs can serve not only as carriers biomarkers for disease diagnosis but also effective drug delivery agents. Furthermore, these involved regulating the onset progression various diseases, reflecting physiological functional states This paper introduces classification vesicles, focus on extraction identification significant role repair, diagnosis, communication. Additionally, addresses engineering modification provide reference enhanced understanding application.
Язык: Английский
Процитировано
0
Cells, Год журнала: 2024, Номер 13(24), С. 2052 - 2052
Опубликована: Дек. 12, 2024
Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial dysfunction, cellular senescence—these aim to restore youthful functionality cells tissues, offering new hope for treating degenerative diseases. Recent advancements have showcased range strategies, including reprogramming, senolytic interventions, restoration, stem cell-based approaches, gene-editing technologies like CRISPR. Each modality has demonstrated substantial potential preclinical models is now being cautiously explored early-stage clinical trials. However, translating these from the laboratory practice presents unique challenges: safety concerns, delivery precision, complex regulatory requirements, ethical considerations, high costs impede widespread adoption. This review examines current landscape rejuvenation, highlighting key advancements, risks, strategies needed overcome hurdles.
Язык: Английский
Процитировано
1
Biomedicines, Год журнала: 2024, Номер 12(11), С. 2478 - 2478
Опубликована: Окт. 28, 2024
Background/Objectives: Osteoarthritis (OA) is a prevalent and debilitating joint disorder characterized by progressive cartilage degradation inflammation, for which traditional treatments offer only symptomatic relief without halting disease progression. Exosomes, cell-free vesicles derived from mesenchymal stem cells, have emerged as promising alternative therapy owing to their regenerative anti-inflammatory properties. Methods: This review synthesizes findings recent studies (2017–2023) on the therapeutic potential of exosomes in OA treatment, highlighting ability modulate microenvironment, reduce promote repair delivering bioactive molecules such cytokines, growth factors, regulatory ribonucleic acids. Results: We explore integration with biomaterials, hydrogels scaffolds, enhance delivery efficacy, we address critical challenges associated clinical application, including standardization isolation characterization methods, scalability production, mechanistic understanding, long-term safety. Despite these challenges, exosome-based therapies several advantages over cell-based treatments, lower immunogenicity, ease handling, targeted agents damaged tissues. Conclusions: provide an analytical perspective current state exosome research OA, emphasizing need standardized production deeper insights, rigorous safety assessments. Future directions should focus optimizing systems, exploring personalized medicine approaches, conducting comparative effectiveness fully realize treatment. Addressing gaps will be crucial translating bench bedside achieving transformative impact management.
Язык: Английский
Процитировано
0
Biomedicine, Год журнала: 2024, Номер 14(4)
Опубликована: Дек. 1, 2024
Introduction: In recent years, significant progress has been made in regenerative medicine, specifically using mesenchymal stem cells (MSCs) due to their and differentiating abilities. An exciting development this area is the utilization of exosomes derived from MSCs, which have shown promise tissue restoration, immune system modulation, cancer treatment.
Язык: Английский
Процитировано
0