Unravelling the Biological Interplay Between Genital HPV Infection and Cervicovaginal Microbiota in Sub-Saharan Africa: Implications for Cervical (Pre)cancer Prevention DOI Creative Commons
Harris Onywera, Zizipho Z. A. Mbulawa, Adrian Brink

и другие.

Venereology, Год журнала: 2024, Номер 3(4), С. 211 - 231

Опубликована: Ноя. 14, 2024

Cervical cancer is more common in Sub-Saharan Africa (SSA) compared to developed countries, with persistent genital high-risk HPV (HR-HPV) infection identified as the cause. However, other factors contributing this gap remain unclear. This review explores potential role of cervicovaginal microbiota (CVM) and cervical development among women SSA. Many African descent, including those from SSA, lack lactobacilli dominance their CVM, which considered a biomarker health. Published literature has associated Lactobacillus-dominated CVM lower risk cancer. The converse true for high diversity non-Lactobacillus-dominated bacterial vaginosis, most form vaginal disorder. findings on relationship between specific abundance disease severity are inconsistent inconclusive due differences study design, population, sampling, confounders. Thus, there need consensus advance research HPV-associated disease. Despite exact mechanisms by influence HR-HPV persistence carcinogenesis being unknown, backbone appears be mediated part following: dysbiosis, elevated pH, ratio L-to-D-lactic acid, cohesive biofilm formation, chronic inflammation, immune dysregulation. Consequently, these promote cellular proliferation, genetic instability, evasion surveillance. calls larger, prospective studies unravel causal links, identify protective features, integrate interventions into prevention strategies

Язык: Английский

Vaginal microbiome distinction in women with HPV+, cervical intraepithelial neoplasia, and cervical cancer, a retrospective study DOI Creative Commons
Yuanyue Li, Xiaomei Wu

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 14

Опубликована: Янв. 17, 2025

The vaginal microbiota is a complex and dynamic micro-ecosystem that plays pivotal role in protecting the host from various pathogens. Previous studies have investigated diversity of microbiome its association with health outcomes, particularly development HPV-related disorders. This study aimed to investigate correlation between microbiota, HPV infection, cervical intraepithelial neoplasias (CINs), cancers 69 women. DNA was extracted samples, followed by genotyping through PCR sequenced the16S rRNA gene. Our results revealed Lactobacillus predominant bacterium across all groups, prevalence rates 60.2% women HPV+, 63.9% CINI, 97.7% CINII, 52.0% CINIII, 36.9% cancer, 70.9% NILM (normal cytology). Additionally, an elevated proportion Gardnerella identified as high-risk associated potentially contributing progression lesions. High-risk genotypes, HPV16, 52, 33, were found be more prevalent among CIN, cancer. We also observed significantly higher alpha HPV+ indicated increased Sobs, Shannon, Ace, Chao indices, compared group. These findings suggest infection pathological conditions are closely linked alterations microbiome. underscores need for further research unravel intricate relationship genotype infections which could pave way new diagnostic therapeutic approaches.

Язык: Английский

Процитировано

0
The Promising Biological Role of Postbiotics in Treating Human Infertility DOI
Nader Khani, Amir Hesam Shakeri, Sousan Houshmandi

и другие.

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

Язык: Английский

Процитировано

0
Unravelling the Biological Interplay Between Genital HPV Infection and Cervicovaginal Microbiota in Sub-Saharan Africa: Implications for Cervical (Pre)cancer Prevention DOI Creative Commons
Harris Onywera, Zizipho Z. A. Mbulawa, Adrian Brink

и другие.

Venereology, Год журнала: 2024, Номер 3(4), С. 211 - 231

Опубликована: Ноя. 14, 2024

Cervical cancer is more common in Sub-Saharan Africa (SSA) compared to developed countries, with persistent genital high-risk HPV (HR-HPV) infection identified as the cause. However, other factors contributing this gap remain unclear. This review explores potential role of cervicovaginal microbiota (CVM) and cervical development among women SSA. Many African descent, including those from SSA, lack lactobacilli dominance their CVM, which considered a biomarker health. Published literature has associated Lactobacillus-dominated CVM lower risk cancer. The converse true for high diversity non-Lactobacillus-dominated bacterial vaginosis, most form vaginal disorder. findings on relationship between specific abundance disease severity are inconsistent inconclusive due differences study design, population, sampling, confounders. Thus, there need consensus advance research HPV-associated disease. Despite exact mechanisms by influence HR-HPV persistence carcinogenesis being unknown, backbone appears be mediated part following: dysbiosis, elevated pH, ratio L-to-D-lactic acid, cohesive biofilm formation, chronic inflammation, immune dysregulation. Consequently, these promote cellular proliferation, genetic instability, evasion surveillance. calls larger, prospective studies unravel causal links, identify protective features, integrate interventions into prevention strategies

Язык: Английский

Процитировано

2