New lines of research in endometrial cancer DOI
Mireia M. Ginestà,

Anna Carbó Bagué,

Julian R. Molina

и другие.

Revisiones en Cáncer, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

The role of B2M in cancer immunotherapy resistance: function, resistance mechanism, and reversal strategies DOI Creative Commons
Xiaowen Han,

Jiayi Zhang,

Weidong Li

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 21, 2025

Immunotherapy has emerged as a preeminent force in the domain of cancer therapeutics and achieved remarkable breakthroughs. Nevertheless, high resistance become most substantial impediment restricting its clinical efficacy. Beta-2 microglobulin (B2M), light chain major histocompatibility complex (MHC) class I, plays an indispensable part by presenting tumor antigens to cytotoxic T lymphocytes (CTLs) for exerting anti-tumor effects. Accumulating evidence indicates that B2M mutation/defect is one key mechanisms underlying immunotherapy resistance. Therefore, elucidating role played devising effective strategies battle against are pressing issues. This review will systematically expound upon them, aiming provide insight into potential promising target anticancer immune response.

Язык: Английский

Процитировано

2
Deep learning to identify aggressive endometrial cancer and predict tumor mutational burden from histopathology slide DOI
Ching‐Wei Wang,

Po-Jen Lai,

Hikam Muzakky

и другие.

Biomedical Signal Processing and Control, Год журнала: 2025, Номер 104, С. 107497 - 107497

Опубликована: Янв. 11, 2025

Язык: Английский

Процитировано

0
Mulberrin suppresses gastric cancer progression and enhances chemosensitivity to oxaliplatin through HSP90AA1/PI3K/AKT axis DOI

Yongsen Li,

Mengyao Dong,

Hong Qin

и другие.

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156441 - 156441

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
The Dual Role of Chaperone-mediated Autophagy in the Response and Resistance to Cancer Immunotherapy DOI Creative Commons
Mohammadreza Saberiyan,

Sarah Gholami,

Mahsa Ejlalidiz

и другие.

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер 210, С. 104700 - 104700

Опубликована: Март 12, 2025

Cancer immunotherapy has become a revolutionary strategy in oncology, utilizing the host immune system to fight malignancies. Notwithstanding major progress, obstacles such as evasion by tumors and development of resistance still remain. This manuscript examines function chaperone-mediated autophagy (CMA) cancer biology, focusing on its effects tumor response resistance. CMA is selective degradation mechanism for cytosolic proteins, which crucial sustaining cellular homeostasis regulating responses. By degrading specific can either facilitate progression stressful conditions, or promote suppression removing oncogenic factors. double-edged sword highlights complexity possible effect treatment results. Here we clarify molecular mechanisms regulate role therapeutic target improving effectiveness immunotherapy.

Язык: Английский

Процитировано

0
Advancing Precision Medicine: Uncovering Biomarkers and Strategies to Mitigate Immune-Related Adverse Events in Immune Checkpoint Inhibitors Therapy DOI Creative Commons

K L Nityashree,

P. Rachitha,

Shilpa Hanchinmane

и другие.

Toxicology Reports, Год журнала: 2025, Номер unknown, С. 102035 - 102035

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
New lines of research in endometrial cancer DOI
Mireia M. Ginestà,

Anna Carbó Bagué,

Julian R. Molina

и другие.

Revisiones en Cáncer, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0