Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones
Diseases,
Год журнала:
2025,
Номер
13(1), С. 7 - 7
Опубликована: Янв. 2, 2025
Urinary
stones
(urolithiasis)
have
been
categorized
as
kidney
(renal
calculus),
ureteric
(ureteral
calculus
and
ureterolith),
bladder
(bladder
urethral
(urethral
calculus);
however,
the
mechanisms
underlying
their
promotion
related
injuries
in
glomerular
tubular
cells
remain
unclear.
Although
lifestyle-related
diseases
(LSRDs)
such
hyperglycemia,
type
2
diabetic
mellitus,
non-alcoholic
fatty
liver
disease/non-alcoholic
steatohepatitis,
cardiovascular
disease
are
risk
factors
for
urolithiasis,
Recently,
heat
shock
protein
90
(HSP90)
on
membrane
of
HK-2
human
proximal
epithelium
has
associated
with
adhesion
urinary
cytotoxicity.
Further,
HSP90
pancreatic
breast
can
be
modified
by
various
advanced
glycation
end-products
(AGEs),
thus
affecting
function.
Hypothesis
1:
We
hypothesized
that
HSP90s
on/in
types
AGEs,
they
may
affect
functions
it
a
key
to
reveal
LSRDs
urolithiasis.
2:
considered
possibility
Japanese
traditional
medicines
urolithiasis
inhibit
AGE
generation.
Of
Choreito
Urocalun
(the
extract
Quercus
salicina
Blume/Quercus
stenophylla
Makino)
used
clinic,
is
Kampo
medicine,
while
characteristic
medicine.
As
contains
quercetin,
hesperidin,
p-hydroxy
cinnamic
acid,
which
generation,
we
generation
AGE-modified
cells.
Язык: Английский
L-Theanine Extends the Lifespan of Caenorhabditis elegans by Reducing the End Products of Advanced Glycosylation
Foods,
Год журнала:
2025,
Номер
14(2), С. 221 - 221
Опубликована: Янв. 13, 2025
L-theanine,
a
non-protein
amino
acid
naturally
occurring
in
tea
leaves,
is
recognized
for
its
antioxidant,
anti-inflammatory,
and
neuroprotective
properties.
Despite
known
benefits,
the
mechanisms
by
which
L-theanine
influences
lifespan
extension
remain
poorly
understood.
This
study
investigated
effects
of
on
Caenorhabditis
elegans
explored
underlying
mechanisms.
Our
findings
indicate
that
significantly
diminishes
accumulation
advanced
glycation
end
products
(AGEs),
are
biomarkers
closely
linked
to
aging
age-related
diseases.
Through
an
AGE-level
analysis,
we
observed
when
administered
during
early
adulthood,
notably
extended
under
both
normal
high-glucose-induced
stress
conditions.
enhanced
typical
conditions
provided
protective
against
stress.
A
further
analysis
demonstrated
extends
modulating
DAF-2/DAF-16
insulin-like
signaling
pathway
reducing
(AGEs).
In
summary,
this
identified
as
potential
anti-aging
intervention
AGE
regulating
pathways.
These
provide
new
insights
developing
strategies
lay
groundwork
research
benefits
mammals.
Future
studies
could
explore
molecular
mechanisms,
test
mammalian
models,
assess
long-term
side
effects.
Язык: Английский