Beta(β)-sitosterol attenuates Chronic Unpredictable Stress (CUS) Induced Testicular Damage in the Experimental Rat Model.

PubMed, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Язык: Английский

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Iron homeostasis and ferroptosis in muscle diseases and disorders: mechanisms and therapeutic prospects

Bone Research, Год журнала: 2025, Номер 13(1)

Опубликована: Фев. 25, 2025

Abstract The muscular system plays a critical role in the human body by governing skeletal movement, cardiovascular function, and activities of digestive organs. Additionally, muscle tissues serve an endocrine function secreting myogenic cytokines, thereby regulating metabolism throughout entire body. Maintaining requires iron homeostasis. Recent studies suggest that disruptions ferroptosis, form iron-dependent cell death, are essential contributors to progression wide range diseases disorders, including sarcopenia, cardiomyopathy, amyotrophic lateral sclerosis. Thus, comprehensive overview mechanisms ferroptosis these conditions is crucial for identifying potential therapeutic targets developing new strategies disease treatment and/or prevention. This review aims summarize recent advances understanding molecular underlying context injury, as well associated disorders. Moreover, we discuss within pathway possible managing Finally, shed light on current limitations future prospects interventions targeting ferroptosis.

Язык: Английский

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Fndc5/irisin mediates the benefits of aerobic exercise intervention on aging-associated sarcopenia in mice

European Geriatric Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Язык: Английский

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The role of irisin in exercise-induced muscle and metabolic health: a narrative review

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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