Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention

International Journal of General Medicine, Год журнала: 2024, Номер Volume 17, С. 5593 - 5609

Опубликована: Ноя. 1, 2024

Diabetic kidney disease (DKD) is a form of damage resulting from diabetes and represents common, severe complication the disease. Globally, DKD leading cause chronic (CKD). occurs in both type 1 2 patients, with early clinical manifestations including microalbuminuria hypertension. As condition progresses, symptoms such as massive proteinuria, hypoalbuminemia, edema may appear. The key to treating lies controlling blood glucose pressure, reducing slowing deterioration function. Acupuncture, traditional Chinese medicine treatment, has shown some therapeutic effects on through mechanisms regulating glucose, improving renal flow microcirculation, antioxidation anti-inflammation, modulating gut microbiota.

Язык: Английский

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Antihypertensive treatment approaches and oxidant-antioxidant system relationship in hypertensive type 2 diabetic patients

Uludağ Üniversitesi Tıp Fakültesi Dergisi, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

A relationship between endothelial dysfunction and oxidative stress has been shown in the pathogenesis of diabetes and/or hypertension. Antihypertensive drugs (angiotensin-converting enzyme inhibitors [ACEi], angiotensin II type 1 receptor blockers [ARB], third-generation beta-blockers) can improve stress. This study evaluated effects losartan (ARB) treatment alone combined with cilazapril (ACEi) or carvedilol on antioxidants hypertensive 2 diabetic patients. Thirty 56 patients completed study. All received 50 mg daily for 6 weeks, then were randomised into three groups weeks. In first group, was increased to 100 mg/day, second third groups, added mg/day treatment, respectively. Apolipoprotein B malondialdehyde (basal Δ-MDA), serum paraoxonase (PON) arylesterase (AE), erythrocyte superoxide dismutase (SOD) glutathione peroxidase (Gpx) parameters studied. The characteristics comparable (p>0.05). Blood pressure (BP) decreased significantly all before after randomisation six-week periods. largest BP decrease seen ARB+ACEi group (systolic BP: 16.5±7.4 mmHg, diastolic 10.5±2.8 mmHg), smallest high-dose ARB 9±6.1 3±4.8 mmHg). Throughout study, no significant changes detected basal Δ-MDA levels SOD, Gpx, PON AE activities inter- intra-group comparisons. Our observations showed that different antihypertensive therapy approaches effectively lowered diabetics but did not affect oxidant antioxidant systems short term.

Язык: Английский

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A Biomarker-Centric Diagnostic Approach based on Neutrophil Percentage to Albumin Ratio (NPAR) for Diabetic UTIs

Pakistan Journal of Health Sciences, Год журнала: 2024, Номер unknown, С. 288 - 295

Опубликована: Ноя. 30, 2024

The Neutrophil Percentage to Albumin Ratio (NPAR) was identified as a promising biomarker for identifying inflammation and renal complications in diabetic Urinary Tract Infections (UTIs). Objective: To evaluate the diagnostic potential of NPAR novel diagnosis prognosis UTIs. Methods: current study carried out according PRISMA criteria determine prognostic value (April 2024 June 2024) made on Google Scholar, Science Direct, PubMed with date ranging from 2014 2024. Articles comparing effect non-diabetic UTI-related inflammation, immune cells suppression, comparison classic biomarkers comorbidities damage were taken review. Information available different world areas, such Asia Pacific, Europe, America’s breadth. first search found 162 papers, but 134 remained after duplicates deleted, these screened reviewed, resulting inclusion 15 studies systematic Results: findings demonstrated that has higher reliability diagnosing than traditional biomarkers, especially septic patients hypoalbuminemia. Conclusions: Due reliability, sensitivity specificity NPAR, it evaluating UTI. Its implementation part clinical practice could extend understanding disorder early identification.

Язык: Английский

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