Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy

Essays in Biochemistry, Год журнала: 2025, Номер 69(02)

Опубликована: Март 28, 2025

The emergence of immunotherapy has led to the clinical approval several related drugs. However, their efficacy against solid tumors remains limited. As hub immune activation, lymph nodes (LNs) play a critical role in tumor by initiating and amplifying responses. Nevertheless, intricate physiological structure barriers within LNs, combined with immunosuppressive microenvironment induced cells, significantly impede therapeutic immunotherapy. Engineered nanoparticles (NPs) have shown great potential overcoming these challenges facilitating targeted drug transport LNs directly or indirectly activating T cells. This review systematically examines structural features key factors influencing targeting efficiency NPs, current strategies for remodeling LNs. Additionally, it discusses future opportunities optimizing NPs enhance immunotherapy, addressing translation safety evaluation.

Язык: Английский

Enhanced Biochemical Properties of Soybean Root Nodule Asparaginase through Plant Molecular Farming Compared to Bacterial Enzyme for Cancer Treatment

Rhizosphere, Год журнала: 2024, Номер unknown, С. 100970 - 100970

Опубликована: Окт. 1, 2024

Язык: Английский