International Journal of Applied Pharmaceutics, Год журнала: 2025, Номер unknown, С. 31 - 38

Опубликована: Март 7, 2025

The review on this fast-evolving field of neuro cosmetics, at the intersection neuroscience and cosmetic science, has interestingly led to innovative skincare treatment approaches. paper progresses from a basic discovery neurogenic inflammation made by substance P in 1996 more recent skin-brain axis 2015 its applications. focuses neurotransmitters such as acetylcholine serotonin, neuropeptides Calcitonin Gene-Related Peptide (CGRP), neuroendocrine cells, Merkel, Langerhans achieve skin homeostasis, control, aging. article looks neurocosmetic applications anti-aging, barrier enhancement, pigmentation management active ingredients acetyl hexapeptide-8, niacinamide, cannabidiol. Also reviewed are delivery systems including nanoencapsulation, microneedle technology, iontophoresis enhancing bioavailability penetration neuroactive compounds. A meta-analysis clinical trials is shown. One study, which lasted up 24 w, registered 27% decrease wrinkles an 18% increase elasticity with peptide complex; second one described 45% rosacea erythema Alpha-Melanocyte Stimulating Hormone (α-MSH) Transient Receptor Potential Vanilloid (TRPV1) antagonists. In review, emerging areas for future research AI-driven personalized neurocosmetics, interventions gut-brain-skin axis, chronocosmetics, epigenetic modulation, smart nanocarriers, bioelectronic therapies. Safety regulatory issues that arise commented on, emphasizing long-term studies standardized apt any researcher or dermatologist looking comprehensive overview how neurocosmetics hold transformative promise topical formulations.

Язык: Английский