The Role of Curcumin in Preventing Naturally Occurring Leiomyoma in the Galline Model DOI Creative Commons
Kazım Şahin, Cemal Orhan, Mehmet Tuzcu

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1732 - 1732

Опубликована: Дек. 21, 2024

Background: Leiomyoma (LM) is the most commonly identified tumor in genital tract, occurring 70–80% of women. The only treatment option surgery, which significantly influences healthcare costs and negatively women’s survival reproductive capacity. Therefore, identifying safe effective chemopreventive modalities needed. Methods: We investigated effects 12 months daily curcumin (0, 25.8, 53 mg/kg) diet on incidence growth spontaneously developing LM tumors a galline (hen) model. Results: were detected 58.9% (53/90) control hens as spontaneous occurrences, while they observed 37.7% (34/90) 24.5% (22/90) treated with doses 25.8 mg or 53.0 mg, respectively, over months. This reduced development by 35% 58.5%, respectively (p = 0.004). also dose-dependent inhibition LM-tumor NF-κB, mTOR, p70S6K1, 4E-BP1 signaling inducing Nrf2/HO1 pathway induction collected from fed < 0.05). Curcumin intake notably levels TGF-β1, α-SMA, collagen type 1, 0.001). Conclusions: findings suggest that consumption reduces naturally LMs suppresses growth. indicates regular may be an preventive measure against LMs.

Язык: Английский

Ophthalmic In Situ Nanocomposite Gel for Delivery of a Hydrophobic Antioxidant DOI Creative Commons
Marta Slavkova, Christina Voycheva, Teodora Popova

и другие.

Gels, Год журнала: 2025, Номер 11(2), С. 105 - 105

Опубликована: Фев. 2, 2025

The topical administration of in situ hydrogels for ocular pathologies is a promising application strategy providing high effectiveness and patient compliance. Curcumin, natural polyphenol, possesses all the prerequisites successful therapy ophthalmic diseases, but unfortunately its physicochemical properties hurdle practical use. Applying composite thermoresponsive hydrogel formulation embedded with polymer nanoparticles potent to overcome identified drawbacks. In present work we prepared uniform spherical (296.4 ± 3.1 nm) efficiently loaded curcumin (EE% 82.5 2.3%) based on biocompatible biodegradable poly-(lactic-co-glycolic acid). They were thoroughly physicochemically characterized terms FTIR, SEM, TGA, DLS, vitro release following Fickian diffusion (45.62 2.37%), stability over 6 months. Their lack cytotoxicity was demonstrated HaCaT cell lines, potential antioxidant protection also outlined, starting from concentrations as low 0.1 µM reaching 41% at 5 µM. An (17% w/v poloxamer 407 0.1% Carbopol) suitable optimized respect gelation temperature (31.40 0.36 °C), gelling time (8.99 0.28 s) upon tears dilution, gel erosion (90.75 4.06%). Upon curcumin-loaded nanoparticle embedding, appropriate pseudoplastic behavior viscosity 35 °C (2129 24 Pa∙s), 6-fold increase permeation, prolonged h.

Язык: Английский

Процитировано

0
Nanoparticle-Based Delivery Systems for Phytochemicals in Cancer Therapy: Molecular Mechanisms, Clinical Evidence, and Emerging Trends DOI
Mahmoud A.H. Mostafa, Hani M. J. Khojah

Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 31

Опубликована: Март 21, 2025

This review examines recent advancements in nanoparticle-based delivery systems for phytochemicals, focusing on their role overcoming multidrug resistance, improving therapeutic efficacy, and facilitating clinical translation. highlights advances nanoparticle-enabled phytochemical to enhance bioavailability, improve outcomes, enable targeted applications. By comparing various nanoparticle systems, formulation methods, efficacy data, it identifies gaps current research guides the development of more effective, next-generation phytochemical-loaded nanocarriers. A systematic literature published between 2000 2024 was conducted using PubMed, Scopus, Web Science. Articles cancer therapy were included. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin gallate demonstrate enhanced anti-cancer when encapsulated nanoparticles, leading improved increased tumor cell targeting, reduced toxicity. Clinical trials indicate regression fewer adverse effects. Emerging approaches-such nanogels, hybrid combination therapies with immune checkpoint inhibitors-further refine treatment efficacy. Nanoparticle-based significantly potential making them promising candidates safer, effective treatments. However, challenges related regulatory guidelines, scalability, long-term safety must be addressed fully realize potential.

Язык: Английский

Процитировано

0
The Potential Benefits of Curcumin-Enriched Diets for Adults with Colorectal Cancer: A Systematic Review DOI Creative Commons

María Neira,

Carlos F. Mena, Keila Torres

и другие.

Antioxidants, Год журнала: 2025, Номер 14(4), С. 388 - 388

Опубликована: Март 26, 2025

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Conventional treatments such as chemotherapy and radiotherapy are often associated with severe side effects limited effectiveness. Curcumin, a polyphenol derived from Curcuma longa, has demonstrated anti-inflammatory anticancer properties. A systematic review recent scientific literature followed PRISMA guidelines to evaluate benefits curcumin-enriched diet for adults colorectal cancer. Articles published between 2018 2024 were retrieved PubMed, SciELO, Google Scholar, Scopus. Studies meeting inclusion criteria focused on curcumin, adults, outcomes. The administration curcumin-containing products was improved survival rates, enhanced quality life, tumor reduction, effects. shows potential an effective adjunct therapy CRC patients, though its bioavailability effects, gastrointestinal discomfort, pose challenges. Addressing these limitations through larger cohorts, extended study durations, formulations enhance essential. Such efforts could enable development personalized dietary recommendations management.

Язык: Английский

Процитировано

0
Curcumin loaded hyaluronan modified niosomes: preparation, characterization and anti-cancer activity on triple-negative breast cancer cells DOI
Mozhgan Abasi, Zaynab Sadeghi Ghadi, Younes Pilehvar‐Soltanahmadi

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106869 - 106869

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Cytotoxic Effects of Plant Secondary Metabolites and Naturally Occurring Bioactive Peptides on Breast Cancer Model Systems: Molecular Mechanisms DOI Creative Commons
Diana Zasheva,

Petko Mladenov,

Silvina Zapryanova

и другие.

Molecules, Год журнала: 2024, Номер 29(22), С. 5275 - 5275

Опубликована: Ноя. 7, 2024

Breast cancer is the second leading cause of death among women, and number mortal cases in diagnosed patients constantly increasing. The search for new plant compounds with antitumor effects very important because side conventional therapy development drug resistance cells. use substances medicine has been well known centuries, but exact mechanism their action far from being elucidated. molecular mechanisms cytotoxicity exerted by secondary metabolites bioactive peptides origin on breast cell lines are subject this review.

Язык: Английский

Процитировано

2
In Silico Analysis of Curcumin's Targeted Cancer Therapy: Folate Receptor Pathways and Molecular Interaction Insights DOI Open Access

K.J. Rajimon,

Rafa Almeer, T. Pooventhiran

и другие.

Chemistry & Biodiversity, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

This study explores the therapeutic potential of curcumin (CUR) in cancer therapy, specifically examining its targeted transport through folate receptors and interaction with certain proteins breast cell lines. We employed molecular docking technique to assess binding affinities CUR 1H1Q, 1UOM, 4JDD, 5U2D MCF10A normal epithelial line protein 5UGB. Out these, CUR-1H1Q complex exhibited greatest affinity. To stability this a biological setting, we conducted dynamics simulations 1H1Q-CUR for duration 100 ns. The demonstrated an extremely stable Cα-backbone, exhibiting consistently low root mean square deviation. radius gyration measurements suggested condensed structure specific areas flexibility. simulation revealed consistent hydrogen bond between indicating robust long-lasting two molecules. results indicate that cytotoxicity on MCF7 lines is mainly affected by interactions several found these cells. Among four tested, 1H1Q has influence. high affinity curcumin, which creation complexes, seems trigger death. Curcumin's biocompatibility toxicological effects were investigated both cancerous enhanced toxicity lines, while demonstrating reduced

Язык: Английский

Процитировано

1
The Role of Curcumin in Preventing Naturally Occurring Leiomyoma in the Galline Model DOI Creative Commons
Kazım Şahin, Cemal Orhan, Mehmet Tuzcu

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1732 - 1732

Опубликована: Дек. 21, 2024

Background: Leiomyoma (LM) is the most commonly identified tumor in genital tract, occurring 70–80% of women. The only treatment option surgery, which significantly influences healthcare costs and negatively women’s survival reproductive capacity. Therefore, identifying safe effective chemopreventive modalities needed. Methods: We investigated effects 12 months daily curcumin (0, 25.8, 53 mg/kg) diet on incidence growth spontaneously developing LM tumors a galline (hen) model. Results: were detected 58.9% (53/90) control hens as spontaneous occurrences, while they observed 37.7% (34/90) 24.5% (22/90) treated with doses 25.8 mg or 53.0 mg, respectively, over months. This reduced development by 35% 58.5%, respectively (p = 0.004). also dose-dependent inhibition LM-tumor NF-κB, mTOR, p70S6K1, 4E-BP1 signaling inducing Nrf2/HO1 pathway induction collected from fed < 0.05). Curcumin intake notably levels TGF-β1, α-SMA, collagen type 1, 0.001). Conclusions: findings suggest that consumption reduces naturally LMs suppresses growth. indicates regular may be an preventive measure against LMs.

Язык: Английский

Процитировано

0