Disease-modifying strategies: Targeting protein kinases in multiple sclerosis and other autoimmune disorders
Autoimmunity Reviews,
Год журнала:
2025,
Номер
24(4), С. 103754 - 103754
Опубликована: Янв. 20, 2025
Язык: Английский
Identification and Therapeutic Potential of Polymethoxylated Flavones in Citri Reticulatae Pericarpium for Alzheimer’s Disease: Targeting Neuroinflammation
Molecules,
Год журнала:
2025,
Номер
30(4), С. 771 - 771
Опубликована: Фев. 7, 2025
Neuroinflammation
is
a
significant
driving
force
in
the
pathogenesis
and
progression
of
central
nervous
system
(CNS)
disorders.
Polymethoxylated
flavones
(PMFs),
key
lipid-soluble
constituents
Citri
Reticulatae
Pericarpium
(CRP),
exhibit
excellent
blood-brain
barrier
permeability
anti-inflammatory
properties,
holding
therapeutic
potential
for
CNS
However,
specific
bioactive
components
effects
PMFs
treating
disorders
are
not
well
understood.
This
study
employed
comprehensive
sequential
metabolism
approach
to
elucidate
dynamic
biotransformation
vivo
identified
seven
brain-targeting
components.
Subsequently,
network
pharmacology
experimental
validation
were
utilized
explore
mechanisms
PMFs.
The
results
suggested
that
have
value
Alzheimer's
disease
(AD)-like
mice,
with
inhibition
neuroinflammation
likely
being
mechanism
their
anti-AD
effects.
Notably,
sinensetin,
tangeretin,
nobiletin,
3,5,6,7,8,3',4'-heptamethoxyflavone
as
potent
neuroinflammatory
inhibitors.
research
elucidated
chemical
foundations
PMFs,
indicating
treatments
or
nutritional
supplements
AD
prevention
treatment.
Moreover,
integrated
triad
metabolism,
pharmacology,
may
serve
promising
strategy
screening
compounds
herbs
functional
foods,
elucidating
mechanisms.
Язык: Английский
The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Март 27, 2025
Alzheimer’s
disease
(AD)
is
a
widespread
neurodegenerative
disorder
and
one
of
the
major
challenges
for
public
health.
Despite
extensive
research,
role
microglia
in
AD
remains
complex
dual.
The
aim
this
review
to
summarize
most
recent
advances
research
regarding
dual
concerning
both
immunomodulation
pathological
progression
by
considering
mechanisms
activation
microglia,
effects
on
Aβ
clearance,
tau
pathology,
impacts
due
genetic
variations
microglial
functions.
Among
these
findings
are
status
M1
M2
phenotypes,
crucial
that
variants
like
TREM2
have
modulating
response
microglia.
This
describes
how
modulation
signaling
pathway
might
be
exploited
therapeutically
treatment
underlines
relevance
personalized
medicine
approach.
Язык: Английский
Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiency
Biotechnology Advances,
Год журнала:
2025,
Номер
unknown, С. 108568 - 108568
Опубликована: Март 1, 2025
Язык: Английский
Role of PI3Kγ in the polarization, migration, and phagocytosis of microglia
Neurochemistry International,
Год журнала:
2024,
Номер
unknown, С. 105917 - 105917
Опубликована: Дек. 1, 2024
Язык: Английский
Revolutionizing Neuroimmunology: Unraveling Immune Dynamics and Therapeutic Innovations in CNS Disorders
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13614 - 13614
Опубликована: Дек. 19, 2024
Neuroimmunology
is
reshaping
the
understanding
of
central
nervous
system
(CNS),
revealing
it
as
an
active
immune
organ
rather
than
isolated
structure.
This
review
delves
into
unprecedented
discoveries
transforming
field,
including
emerging
roles
microglia,
astrocytes,
and
blood–brain
barrier
(BBB)
in
orchestrating
neuroimmune
dynamics.
Highlighting
their
dual
both
repair
disease
progression,
we
uncover
how
these
elements
contribute
to
intricate
pathophysiology
neurodegenerative
diseases,
cerebrovascular
conditions,
CNS
tumors.
Novel
insights
microglial
priming,
astrocytic
cytokine
networks,
meningeal
lymphatics
challenge
conventional
paradigms
privilege,
offering
fresh
perspectives
on
mechanisms.
work
introduces
groundbreaking
therapeutic
innovations,
from
precision
immunotherapies
controlled
modulation
BBB
using
nanotechnology
focused
ultrasound.
Moreover,
explore
fusion
with
neuromodulatory
technologies,
underscoring
new
frontiers
for
personalized
medicine
previously
intractable
diseases.
By
synthesizing
advancements,
propose
a
transformative
framework
that
integrates
cutting-edge
research
clinical
translation,
charting
bold
path
toward
redefining
management
era
neuroimmunology.
Язык: Английский