Role of Nanomedicine in Transforming Pharmacotherapy for Substance Use Disorder (SUD) DOI Creative Commons
Akshata Y. Patne, Subhra Mohapatra, Shyam S. Mohapatra

и другие.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2025, Номер 17(2)

Опубликована: Март 1, 2025

ABSTRACT The field of nanomedicine offers revolutionary potential to reshape the discovery and development therapeutics for diverse human diseases. However, its application has been limited in improving Substance Use Disorders (SUDs), which represent a profound public health crisis, including major types such as opioid, alcohol, stimulant, cannabis use disorders. Pharmacotherapy, cornerstone SUD management, reduced morbidity, mortality, societal impact addiction, though efficacy ranged from none moderate. Thus, there is unmet need transform pharmacotherapy curb epidemic addiction. This article explores roles nanomedicine‐inspired precision‐targeted drug delivery, sustained release, combination therapies increase therapeutic minimize side effects. Additionally, it discusses innovative mechanisms that align with neurobiological complexities addiction synergistic approaches integrate behavioral interventions, device‐based therapies, emerging modalities immunotherapy neurostimulation. Despite these advancements, barriers treatment accessibility, adherence challenges, inequitable resource distribution persist, particularly underserved populations. By harnessing transformative capabilities integrating into holistic, equitable, personalized care frameworks, this review highlights path forward revolutionize landscape. underscores continued nano‐SUD research strategies alleviate substantial burden on individuals, families, society.

Язык: Английский

Biological AIE Molecules: Innovations in Synthetic Design and AI‐Driven Discovery DOI Open Access

Raj Dave,

Kshipra Pandey,

Vijay Khatri

и другие.

Advanced Biology, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract Biological aggregation ‐induced emission (AIE) molecules offer significant advantages over synthetic organic fluorophores, particularly in biocompatibility, environmental sustainability, and properties biological systems. Derived from biomolecules such as peptides, proteins, nucleic acids, AIE hold great promise for applications biosensing, bioimaging, target drug delivery. This review explores the design principles, mechanistic insights, functional of whiles highlighting role artificial intelligence (AI) accelerating their discovery optimization. AI‐driven approaches, including machine learning computational modeling, are transforming identification synthesis by enabling precise structural modifications enhanced fluorescence efficiency. These advancements paving way integration next‐generation smart biomedical devices, personalized medicine sustainable technological applications. Emerging trends, hybrid biomaterials, Ai‐guided molecular engineering, advanced imaging techniques, expanding scope healthcare monitoring. The synergy between AI is unlocking new frontiers technology, transformative material science applications, shaping future fluorescence‐ based diagnostics therapeutics.

Язык: Английский

Процитировано

0
Is there a continued need for behavioral pharmacology in the discovery and development of medicines? DOI

Jeffrey M. Witkin,

Jodi L. Smith, Daniel P. Radin

и другие.

Journal of Pharmacology and Experimental Therapeutics, Год журнала: 2025, Номер unknown, С. 103571 - 103571

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Role of Nanomedicine in Transforming Pharmacotherapy for Substance Use Disorder (SUD) DOI Creative Commons
Akshata Y. Patne, Subhra Mohapatra, Shyam S. Mohapatra

и другие.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2025, Номер 17(2)

Опубликована: Март 1, 2025

ABSTRACT The field of nanomedicine offers revolutionary potential to reshape the discovery and development therapeutics for diverse human diseases. However, its application has been limited in improving Substance Use Disorders (SUDs), which represent a profound public health crisis, including major types such as opioid, alcohol, stimulant, cannabis use disorders. Pharmacotherapy, cornerstone SUD management, reduced morbidity, mortality, societal impact addiction, though efficacy ranged from none moderate. Thus, there is unmet need transform pharmacotherapy curb epidemic addiction. This article explores roles nanomedicine‐inspired precision‐targeted drug delivery, sustained release, combination therapies increase therapeutic minimize side effects. Additionally, it discusses innovative mechanisms that align with neurobiological complexities addiction synergistic approaches integrate behavioral interventions, device‐based therapies, emerging modalities immunotherapy neurostimulation. Despite these advancements, barriers treatment accessibility, adherence challenges, inequitable resource distribution persist, particularly underserved populations. By harnessing transformative capabilities integrating into holistic, equitable, personalized care frameworks, this review highlights path forward revolutionize landscape. underscores continued nano‐SUD research strategies alleviate substantial burden on individuals, families, society.

Язык: Английский

Процитировано

0