Ant Colony-Inspired Adaptive Peptide Nanoregulators Remodeling the Endothelial Barrier to Alleviate Inflammatory Responses DOI
Meng Li, Yining Zhang,

Kai Xiang

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Endothelial barrier disruption exacerbates inflammation and tissue injury, posing dual challenges of reconstructing tight junctions precisely regulating the local microenvironment. Traditional multidrug therapies often struggle with rapid drug leakage due to dysfunction limited synergy between therapeutic agents. Here, a strategy is proposed inspired by "ant colony collaboration", developing an "all-in-one" conformationally adaptive peptide nanoregulator (VJP NPs) through intelligent integration three functional peptides. VJP NPs strategically harness overexpression vascular cell adhesion protein 1 (VCAM-1), enabling selective targeting inflamed endothelium under guidance VHPK while accumulating within inflammatory The nanoregulators disassemble in response high ROS levels, efficiently scavenging excess ROS. Simultaneously, they release PMX peptide, competitively binding complement receptor C5aR regulate cascade. Furthermore, JIP restore endothelial barrier, reducing immune infiltration. As demonstrated mouse model acute lung injury (ALI), markedly promote pulmonary repair, effectively attenuating responses alleviating injury. This peptide-based nanoplatform boosts delivery efficiency via nanoprodrug amplifies synergistic effects, highlighting its potential restoration modulation.

Язык: Английский

Ant Colony-Inspired Adaptive Peptide Nanoregulators Remodeling the Endothelial Barrier to Alleviate Inflammatory Responses DOI
Meng Li, Yining Zhang,

Kai Xiang

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Endothelial barrier disruption exacerbates inflammation and tissue injury, posing dual challenges of reconstructing tight junctions precisely regulating the local microenvironment. Traditional multidrug therapies often struggle with rapid drug leakage due to dysfunction limited synergy between therapeutic agents. Here, a strategy is proposed inspired by "ant colony collaboration", developing an "all-in-one" conformationally adaptive peptide nanoregulator (VJP NPs) through intelligent integration three functional peptides. VJP NPs strategically harness overexpression vascular cell adhesion protein 1 (VCAM-1), enabling selective targeting inflamed endothelium under guidance VHPK while accumulating within inflammatory The nanoregulators disassemble in response high ROS levels, efficiently scavenging excess ROS. Simultaneously, they release PMX peptide, competitively binding complement receptor C5aR regulate cascade. Furthermore, JIP restore endothelial barrier, reducing immune infiltration. As demonstrated mouse model acute lung injury (ALI), markedly promote pulmonary repair, effectively attenuating responses alleviating injury. This peptide-based nanoplatform boosts delivery efficiency via nanoprodrug amplifies synergistic effects, highlighting its potential restoration modulation.

Язык: Английский

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