Materials chemistry horizons., Год журнала: 2024, Номер 3(3), С. 1 - 14
Опубликована: Дек. 1, 2024
Язык: Английский
Cancer Cell International, Год журнала: 2025, Номер 25(1)
Опубликована: Март 7, 2025
High mobility group A1 (HMGA1) is a class of non-histone chromosomal protein and highly expressed in the embryonic period many tumors. It involved multiple hallmarks tumors affects occurrence progression Nowadays, non-coding RNAs (ncRNAs), such as miRNA, lncRNA, circRNA, have been found to play crucial role HMGA1 regulation. Moreover, some ncRNAs are reported be downstream effectors HMGA1. They interact with each other affect cancer targeting or may provide potential strategies for therapy. In this review, we give an overview recent studies describing crosstalk between oncogenic ncRNAs. We also point out impact interaction on biological behavior their tumor therapy order offer implications directions both basic science clinical applications.
Язык: Английский
Процитировано
0
Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12
Опубликована: Март 20, 2025
RNA therapeutics are emerging as a promising approach for cardiovascular diseases (CVDs) management, offering targeted gene regulation through modalities like mRNA, siRNA, and miRNA. In recent years, researchers have conducted lot of research on the application technology in treatment CVDs. Despite hurdles off-target effects immune responses, clinical trial outcomes encouraging. This review synthesizes current progress CVDs, examining their mechanisms, advantages, challenges delivery safety. We highlight potential personalized medicine, combination artificial intelligence (AI) bioinformatics advancing therapeutics. The future CVDs is poised significant impact, necessitating continued interdisciplinary collaboration to optimize these treatments ensure patient safety efficacy.
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113641 - 113641
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2024, Номер 13(1), С. 47 - 47
Опубликована: Дек. 28, 2024
Gastrointestinal tumors present a significant challenge for precision medicine due to their complexity, necessitating the development of more specific diagnostic tools and therapeutic agents. Recent advances have positioned coding non-coding RNAs as emerging biomarkers these malignancies, detectable by liquid biopsies, innovative Many RNA-based therapeutics, such small interfering RNA (siRNA) antisense oligonucleotides (ASO), entered clinical trials or are available on market. This review provides narrative examination potential in gastrointestinal cancers, with an emphasis its application medicine. discusses current challenges, drug resistance tumor metastasis, highlights how molecules can be leveraged targeted detection treatment. Additionally, this categorizes targets based tissue type, offering comprehensive analysis role advancing tumors.
Язык: Английский
Процитировано
0
Science China Life Sciences, Год журнала: 2024, Номер unknown
Опубликована: Дек. 28, 2024
Язык: Английский
Процитировано
0
Materials chemistry horizons., Год журнала: 2024, Номер 3(3), С. 1 - 14
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0