A study on the estrogenic effects of Benzophenone-2 in adult ovariectomized mice
Ahmed Lasaneya,
Jogen Chandra Kalita
The Journal of Basic and Applied Zoology,
Год журнала:
2025,
Номер
86(1)
Опубликована: Апрель 17, 2025
Abstract
Background
Benzophenone-2
(BP2)
is
an
ultraviolet
absorber
extensively
used
in
personal
care
products.
Due
to
rising
infertility
issues
and
scarce
scientific
data
on
its
effect
female
reproductive
health,
this
study
aimed
investigate
the
possible
estrogenic
effects
of
BP2
adult
mice
following
bilateral
ovariectomy.
Experimental
were
randomly
assigned
6
groups,
The
Sham
OVX
Control
groups
received
subcutaneous
olive
oil
treatment,
while
other
three
administered
with
subcutaneously
daily
at
a
dose
50,100
200
mg/kg
bw
for
time
frame
7
21
days
consecutively
alongside
positive
17β-estradiol
group
1
µg/kg
two
successive
periods
(7
days)
too.
activity
was
assessed
through
vaginal
cornification,
uterine
weight,
serum
estrogen,
progesterone,
FSH
LH
levels,
histopathological
analysis
uterus.
Results
different
concentrations
treated
ovariectomized
increased
cornification
(20.0
±
1.6%
50.6
0.7%
respectively
bw;
P
<
0.001),
weight
(0.062
0
g
estradiol
levels
(17.4
1.6
pg/ml
0.05)
compared
group.
Histopathological
uterus
revealed
atrophy
untreated
At
same
time,
BP2-treated
exhibited
enhanced
endometrial
glands,
proliferative
luminal
epithelial
cells,
lumen
size,
myometrial
response.
These
comparable
those
observed
Conclusion
(BP2),
may
possess
mice,
could
induce
modifications
as
well
interference
normal
hormone
balance
function.
Язык: Английский
Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake
Journal of Xenobiotics,
Год журнала:
2024,
Номер
15(1), С. 1 - 1
Опубликована: Дек. 24, 2024
Addressing
the
consequences
of
exposure
to
endocrine-disrupting
chemicals
(EDCs)
demands
thorough
research
and
elucidation
mechanism
by
which
EDCs
negatively
impact
women
lead
breast
cancer
(BC).
Endocrine
disruptors
can
affect
major
pathways
through
various
means,
including
histone
modifications,
erroneous
expression
microRNA
(miRNA),
DNA
methylation,
epigenetic
modifications.
However,
it
is
still
uncertain
if
modifications
triggered
help
predict
negative
outcomes.
Consequently,
important
understand
how
different
endocrine
disrupters
or
signals
interact
with
regulate
signalling
mechanisms.
This
study
proposes
that
epigenome
may
be
impacted
several
EDCs,
such
as
cadmium,
arsenic,
lead,
bisphenol
A,
phthalates,
polychlorinated
biphenyls
parabens,
organochlorine,
dioxins.
Further,
this
also
examines
on
lifestyle
variables.
In
research,
essential
consider
potential
impacts
EDC
comprehend
function
in
tissues.
Язык: Английский