Association of Subclinical Inflammation Markers with Primary Hypertension in Children—A Systematic Review with Meta-Analysis DOI Open Access

Katarzyna Dziedzic-Jankowska,

Maciej Kołodziej, Piotr Skrzypczyk

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2319 - 2319

Опубликована: Март 28, 2025

Background/Objectives: This systematic review and meta-analysis aimed to determine whether there is an association between low-grade inflammation markers primary hypertension (PH) in children. Methods: The MEDLINE, EMBASE, Cochrane databases were searched up March 2025 for cohort, cross-sectional, case-control studies; additional references obtained from reviewed articles. studies needed investigate any PH. Participants of the study children (<18 years old) with PH healthy controls. included 13 published 2005 2024, enrolling 1306 patients (745 561 controls). data analyzed using Review Manager. Pooled mean difference (MD) a 95% confidence interval (95% CI) was used assess differences markers. Results: There significant hypertensive control groups high-sensitivity C-reactive protein (hs-RCP) concentration (mean (MD): 0.07 95%CI (0.04, 0.09)), intercellular adhesion molecule 1 (ICAM-1) (MD: 85.28 95%CI: (50.57-119.99)), vascular cell (VCAM-1) 259.78 (22.65-496.91)), neutrophil count 0.90 (0.66-1.14)), monocyte 0.08 95CI%: (0.04-0.11)), platelet 20.24 (4.27-36.21)), neutrophil-to-lymphocyte ratio 0.48 (0.34-0.62)), lymphocyte-to-monocyte -0.52 (-1.02--0.02)). no terms interleukin 6 (IL-6), lymphocyte count, volume (MPV), or platelet-to-lymphocyte (PLR) ratio. Conclusions: Some easily accessible might be as tool diagnosis screening These results should validated large well-conducted studies.

Язык: Английский

Association of Subclinical Inflammation Markers with Primary Hypertension in Children—A Systematic Review with Meta-Analysis DOI Open Access

Katarzyna Dziedzic-Jankowska,

Maciej Kołodziej, Piotr Skrzypczyk

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2319 - 2319

Опубликована: Март 28, 2025

Background/Objectives: This systematic review and meta-analysis aimed to determine whether there is an association between low-grade inflammation markers primary hypertension (PH) in children. Methods: The MEDLINE, EMBASE, Cochrane databases were searched up March 2025 for cohort, cross-sectional, case-control studies; additional references obtained from reviewed articles. studies needed investigate any PH. Participants of the study children (<18 years old) with PH healthy controls. included 13 published 2005 2024, enrolling 1306 patients (745 561 controls). data analyzed using Review Manager. Pooled mean difference (MD) a 95% confidence interval (95% CI) was used assess differences markers. Results: There significant hypertensive control groups high-sensitivity C-reactive protein (hs-RCP) concentration (mean (MD): 0.07 95%CI (0.04, 0.09)), intercellular adhesion molecule 1 (ICAM-1) (MD: 85.28 95%CI: (50.57-119.99)), vascular cell (VCAM-1) 259.78 (22.65-496.91)), neutrophil count 0.90 (0.66-1.14)), monocyte 0.08 95CI%: (0.04-0.11)), platelet 20.24 (4.27-36.21)), neutrophil-to-lymphocyte ratio 0.48 (0.34-0.62)), lymphocyte-to-monocyte -0.52 (-1.02--0.02)). no terms interleukin 6 (IL-6), lymphocyte count, volume (MPV), or platelet-to-lymphocyte (PLR) ratio. Conclusions: Some easily accessible might be as tool diagnosis screening These results should validated large well-conducted studies.

Язык: Английский

Процитировано

0