International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3653 - 3653
Опубликована: Апрель 12, 2025
Despite the emerging evidence of role transcriptional regulators in schizophrenia as key molecular effectors responsible for dysregulation multiple biological processes, limited information is available brain areas that control higher cognitive functions, such cerebellum. To identify transcription factors could a wide panel altered proteins cerebellar cortex schizophrenia, we analyzed dataset obtained using one-shot liquid chromatography–tandem mass spectrometry on postmortem human chronic (PXD024937 identifier ProteomeXchange repository). Our analysis revealed 11 enriched (SP1, KLF7, SP4, EGR1, HNF4A, CTCF, GABPA, NRF1, NFYA, YY1, and MEF2A) be controlling 250 proteins. The top three significantly were SP1, with largest number targets SP4 which belong to Krüppel superfamily. An enrichment vesicle-mediated transport was found MEF2A targets, while pathways related signaling, inflammation/immune responses, apoptosis, energy SP1 KLF7 targets. EGR1 RNA processing, GABPA YY1 mainly involved organelle organization assembly. This study provides reduced impact through cerebellum schizophrenia. These findings suggest this represent pharmacological interventions
Язык: Английский