Protease-activated receptors in vascular smooth muscle cells: a bridge between thrombo-inflammation and vascular remodelling DOI Creative Commons
Anxhela Habibi, Wolfram Ruf, Leon J. Schurgers

и другие.

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 31, 2025

Coagulation factors are responsible for blood clot formation yet have also non-canonical functions as signalling molecules. In this context, they can activate protease-activated receptors (PARs) ubiquitously expressed in the vasculature. During vascular repair, smooth muscle cells (VSMCs) will switch from a contractile to synthetic reparative phenotype. prolonged stress, VSMCs acquire pathological phenotype leading cardiovascular disease. Activated coagulation impact on vessel wall permeability and integrity after injury with key role PAR activation endothelial cells. The of PARs supports repair following injury. Prolonged activation, however, results remodelling. Therefore, understanding mechanisms is propel our molecular cellular develop novel therapeutic strategies resolve remodelling.In review, we discuss recent advances specifically their remodelling contributing Additionally, current targeting - indirectly or directly relation

Язык: Английский

Protease-activated receptors in vascular smooth muscle cells: a bridge between thrombo-inflammation and vascular remodelling DOI Creative Commons
Anxhela Habibi, Wolfram Ruf, Leon J. Schurgers

и другие.

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 31, 2025

Coagulation factors are responsible for blood clot formation yet have also non-canonical functions as signalling molecules. In this context, they can activate protease-activated receptors (PARs) ubiquitously expressed in the vasculature. During vascular repair, smooth muscle cells (VSMCs) will switch from a contractile to synthetic reparative phenotype. prolonged stress, VSMCs acquire pathological phenotype leading cardiovascular disease. Activated coagulation impact on vessel wall permeability and integrity after injury with key role PAR activation endothelial cells. The of PARs supports repair following injury. Prolonged activation, however, results remodelling. Therefore, understanding mechanisms is propel our molecular cellular develop novel therapeutic strategies resolve remodelling.In review, we discuss recent advances specifically their remodelling contributing Additionally, current targeting - indirectly or directly relation

Язык: Английский

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