Glucocorticoid receptor inhibits Th2 immune responses by down-regulating Pparg and Gata3 in schistosomiasis DOI Creative Commons
Tao Sun, Xiaojuan Bi, Ning Yang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 24, 2025

Introduction The Th2 immune response plays a pivotal role in the pathogenesis of schistosomiasis, contributing to formation hepatic granulomas and fibrosis. While glucocorticoid receptor (GR) is ubiquitously expressed nuclear that mediates anti-inflammatory effects, its impact on responses schistosomiasis remains underexplored. Thus, this study aimed investigate potential GR activation using synthetic dexamethasone. Method In vivo , Schistosoma japonicum -infected mice were treated with dexamethasone, while vitro studies conducted cells. Additionally, RNA sequencing single-cell integrated identify key transcription factors influenced by during cell differentiation, gene expression levels validated both vitro. Results markedly reduced size egg substantially repressed Th2-related cytokines, such as IL-4, IL-5, IL-13. inhibited IL-13, well secretion IL-4 An analysis revealed downregulated two major factors, Gata3 Pparg, which elevated infected mouse livers cells but decreased following dexamethasone treatment. Conclusion may suppress triggered antigens downregulating Pparg. these findings provide insights into complementary therapeutic strategy, further research necessary assess feasibility safety targeting for treatment schistosomiasis.

Язык: Английский

Glucocorticoid receptor inhibits Th2 immune responses by down-regulating Pparg and Gata3 in schistosomiasis DOI Creative Commons
Tao Sun, Xiaojuan Bi, Ning Yang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 24, 2025

Introduction The Th2 immune response plays a pivotal role in the pathogenesis of schistosomiasis, contributing to formation hepatic granulomas and fibrosis. While glucocorticoid receptor (GR) is ubiquitously expressed nuclear that mediates anti-inflammatory effects, its impact on responses schistosomiasis remains underexplored. Thus, this study aimed investigate potential GR activation using synthetic dexamethasone. Method In vivo , Schistosoma japonicum -infected mice were treated with dexamethasone, while vitro studies conducted cells. Additionally, RNA sequencing single-cell integrated identify key transcription factors influenced by during cell differentiation, gene expression levels validated both vitro. Results markedly reduced size egg substantially repressed Th2-related cytokines, such as IL-4, IL-5, IL-13. inhibited IL-13, well secretion IL-4 An analysis revealed downregulated two major factors, Gata3 Pparg, which elevated infected mouse livers cells but decreased following dexamethasone treatment. Conclusion may suppress triggered antigens downregulating Pparg. these findings provide insights into complementary therapeutic strategy, further research necessary assess feasibility safety targeting for treatment schistosomiasis.

Язык: Английский

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