Impact of SARS-CoV-2 Variants and Vaccination on Pediatric Febrile Seizures: A Retrospective Cohort Study
Abstract
Objective
This
study
aimed
to
investigate
the
associations
between
SARS-CoV-2
variants,
neuroinflammatory
markers,
vaccination
history,
and
demographic
characteristics
in
relation
occurrence
of
febrile
seizures
(FS)
pediatric
patients
at
a
single
tertiary
medical
center.
Methods
Retrospective
cohort
data
were
collected
from
care
institution
April
2020
January
2023,
encompassing
339
with
PCR-confirmed
infections.
The
was
separated
into
FS
(n=102)
control
(n=237)
groups.
A
multivariable
logistic
regression
analysis
employed
evaluate
impact
viral
variants
(Delta
Omicron
sublineages),
inflammatory
markers
(IL-6,
D-dimer,
CRP),
status
(unvaccinated,
partially
vaccinated,
fully
vaccinated),
variables,
while
controlling
for
potential
confounders.
Results
incidence
among
infants
under
one
year
age
found
be
41.2%,
contrast
17.7%
older
children
(OR=3.2,
95%
CI:
1.8–5.7;
P <0.001).
Elevated
levels
IL-6
exceeding
10
pg/mL
D-dimer
surpassing
0.5
mg/L
independently
associated
increased
severity
(adjusted
OR
[aOR]=2.8
2.1,
respectively),
as
well
3.1-fold
increase
risk
recurrence.
Full
linked
68%
reduction
(aOR=0.32,
0.18–0.55),
particularly
benefiting
infants.
Additionally,
male
exhibited
1.8-fold
vulnerability
(P =0.016).
sublineages
(BA.5/XBB),
which
accounted
78.4%
cases,
correlated
heightened
biomarker
levels.
Conclusion
findings
suggest
that
serve
valuable
indicators
assessing
infected
SARS-CoV-2.
protective
effect
on
neural
tissues,
addition
its
role
reducing
transmission,
is
evident,
highlighting
susceptibility
Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
Язык: Английский