Viral Infections in Elderly Individuals: A Comprehensive Overview of SARS-CoV-2 and Influenza Susceptibility, Pathogenesis, and Clinical Treatment Strategies DOI Creative Commons

Yanhao Huang,

Shumin Li, Wenjie Ye

и другие.

Vaccines, Год журнала: 2025, Номер 13(4), С. 431 - 431

Опубликована: Апрель 21, 2025

As age increases, the immune function of elderly individuals gradually decreases, increasing their susceptibility to infectious diseases. Therefore, further research on common viral infections in population, especially severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses, is crucial for scientific progress. This review delves into genetic structure, infection mechanisms, impact coinfections with these two viruses provides a detailed analysis reasons increased dual infections. We evaluated clinical manifestations following coinfections, including complications respiratory, gastrointestinal, nervous, cardiovascular systems. Ultimately, we have summarized current strategies prevention, diagnosis, treatment SARS-CoV-2 older adults. Through studies, aim reduce risk provide basis age-related diseases, thereby improving health status.

Язык: Английский

Beyond the Pandemic Era: Recent Advances and Efficacy of SARS-CoV-2 Vaccines Against Emerging Variants of Concern DOI Creative Commons
Ankita Saha, Sounak Ghosh Roy, Richa Dwivedi

и другие.

Vaccines, Год журнала: 2025, Номер 13(4), С. 424 - 424

Опубликована: Апрель 17, 2025

Vaccination has been instrumental in curbing the transmission of SARS-CoV-2 and mitigating severity clinical manifestations associated with COVID-19. Numerous COVID-19 vaccines have developed to this effect, including BioNTech-Pfizer Moderna’s mRNA vaccines, as well adenovirus vector-based such Oxford–AstraZeneca. However, emergence new variants subvariants SARS-CoV-2, characterized by enhanced transmissibility immune evasion, poses significant challenges efficacy current vaccination strategies. In review, we aim comprehensively outline landscape emerging concern (VOCs) sub-lineages that recently surfaced post-pandemic years. We assess effectiveness existing their booster doses, against these subvariants, BA.2-derived sub-lineages, XBB BA.2.86 (Pirola). Furthermore, discuss latest advancements vaccine technology, multivalent pan-coronavirus approaches, along development several next-generation coronavirus exosome-based, virus-like particle (VLP), mucosal, nanomaterial-based vaccines. Finally, highlight key critical areas for future research address evolving threat develop strategies combating viral threats, thereby improving preparedness pandemics.

Язык: Английский

Процитировано

0
Viral Infections in Elderly Individuals: A Comprehensive Overview of SARS-CoV-2 and Influenza Susceptibility, Pathogenesis, and Clinical Treatment Strategies DOI Creative Commons

Yanhao Huang,

Shumin Li, Wenjie Ye

и другие.

Vaccines, Год журнала: 2025, Номер 13(4), С. 431 - 431

Опубликована: Апрель 21, 2025

As age increases, the immune function of elderly individuals gradually decreases, increasing their susceptibility to infectious diseases. Therefore, further research on common viral infections in population, especially severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses, is crucial for scientific progress. This review delves into genetic structure, infection mechanisms, impact coinfections with these two viruses provides a detailed analysis reasons increased dual infections. We evaluated clinical manifestations following coinfections, including complications respiratory, gastrointestinal, nervous, cardiovascular systems. Ultimately, we have summarized current strategies prevention, diagnosis, treatment SARS-CoV-2 older adults. Through studies, aim reduce risk provide basis age-related diseases, thereby improving health status.

Язык: Английский

Процитировано

0