Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia DOI Creative Commons
Yujie Yang, Chunchu Deng,

Fatima Aldali

и другие.

Cells, Год журнала: 2025, Номер 14(6), С. 409 - 409

Опубликована: Март 11, 2025

Small extracellular vesicles (sEVs), including exosomes as a subtype, with diameter typically less than 200 nm and originating from the endosomal system, are capable of transporting diverse array bioactive molecules, proteins, nucleic acids, lipids, thereby facilitating intercellular communication modulating cellular functions. Vascular dementia (VaD) represents form cognitive impairment attributed to cerebrovascular disease, characterized by complex multifaceted pathophysiological mechanism. Currently, therapeutic approach VaD predominantly emphasizes symptom management, no specific pharmacological treatment exists cure condition. Recent investigations have illuminated significant role sEVs in pathogenesis vascular dementia. This review seeks provide comprehensive analysis characteristics functions sEVs, particular focus on their involvement its underlying mechanisms. The objective is advance understanding interplays between dementia, offering novel insights for future research strategies.

Язык: Английский

Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia DOI Creative Commons
Yujie Yang, Chunchu Deng,

Fatima Aldali

и другие.

Cells, Год журнала: 2025, Номер 14(6), С. 409 - 409

Опубликована: Март 11, 2025

Small extracellular vesicles (sEVs), including exosomes as a subtype, with diameter typically less than 200 nm and originating from the endosomal system, are capable of transporting diverse array bioactive molecules, proteins, nucleic acids, lipids, thereby facilitating intercellular communication modulating cellular functions. Vascular dementia (VaD) represents form cognitive impairment attributed to cerebrovascular disease, characterized by complex multifaceted pathophysiological mechanism. Currently, therapeutic approach VaD predominantly emphasizes symptom management, no specific pharmacological treatment exists cure condition. Recent investigations have illuminated significant role sEVs in pathogenesis vascular dementia. This review seeks provide comprehensive analysis characteristics functions sEVs, particular focus on their involvement its underlying mechanisms. The objective is advance understanding interplays between dementia, offering novel insights for future research strategies.

Язык: Английский

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