Life, Год журнала: 2025, Номер 15(4), С. 627 - 627

Опубликована: Апрель 8, 2025

New roles for immune cells, overcoming the classical cytotoxic response, have been highlighted by growing evidence. The such as neutrophils, monocytes/macrophages, and eosinophils, are versatile cells involved in release of web-like DNA structures called extracellular traps (ETs) which represent a relevant mechanism these prevent microbes’ dissemination. In this process, many enzymes, elastase, myeloperoxidase (MPO), microbicidal nuclear granule proteins, contribute to clearance entrapped microorganisms after binding, involved. However, an overproduction ETs can cause unwanted dangerous effects host, resulting several pathological manifestations, among chronic inflammatory disorders, autoimmune diseases, cancer, diabetes. review, we discuss mechanisms double-edged sword role both physiological contexts. addition, evaluated some possible strategies target aimed at either preventing their formation or degrading existing ones.

Язык: Английский