Effects of Low and High Doses of Deoxynivalenol on Growth Performance, Blood Biochemistry, Histology, Metabolites, and Microbial Community in Adult Rats DOI Creative Commons
Jin Young Jeong, Junsik Kim, Bo Ram Lee

и другие.

Biology, Год журнала: 2025, Номер 14(4), С. 429 - 429

Опубликована: Апрель 16, 2025

Deoxynivalenol (DON) is a widespread mycotoxin which contaminates several crops, including maize, wheat, and barley. In this study, we investigated the effects of orally administered DON on growth performance, blood biochemistry, histology, gut microbiome, metabolism in rats. Six-week-old rats, acclimatized for one week, were subjected to different dietary treatments 42 days, as follows: CON (control): 0.9% saline; T1: 0.5 ppm DON; T2: 50 T3: 100 DON. The T3 group had lowest final body weight (298.5 ± 3.69 g) average daily gain compared with control (338.9 6.43 g, p < 0.05). feed conversion ratio was highest (4.28 0.28) that (3.12 0.13, treatment significantly reduced serum levels creatinine, amylase, urea nitrogen, alkaline phosphatase, but not alanine aminotransferase. Fibrosis apoptosis exacerbated various tissues increasing concentration. metabolite profiles DON-treated groups. cecum, increased abundance Desulfobacteria, while decreasing Firmicutes. Our results indicate above maximum residue limit have serious health consequences animals.

Язык: Английский

Effects of Low and High Doses of Deoxynivalenol on Growth Performance, Blood Biochemistry, Histology, Metabolites, and Microbial Community in Adult Rats DOI Creative Commons
Jin Young Jeong, Junsik Kim, Bo Ram Lee

и другие.

Biology, Год журнала: 2025, Номер 14(4), С. 429 - 429

Опубликована: Апрель 16, 2025

Deoxynivalenol (DON) is a widespread mycotoxin which contaminates several crops, including maize, wheat, and barley. In this study, we investigated the effects of orally administered DON on growth performance, blood biochemistry, histology, gut microbiome, metabolism in rats. Six-week-old rats, acclimatized for one week, were subjected to different dietary treatments 42 days, as follows: CON (control): 0.9% saline; T1: 0.5 ppm DON; T2: 50 T3: 100 DON. The T3 group had lowest final body weight (298.5 ± 3.69 g) average daily gain compared with control (338.9 6.43 g, p < 0.05). feed conversion ratio was highest (4.28 0.28) that (3.12 0.13, treatment significantly reduced serum levels creatinine, amylase, urea nitrogen, alkaline phosphatase, but not alanine aminotransferase. Fibrosis apoptosis exacerbated various tissues increasing concentration. metabolite profiles DON-treated groups. cecum, increased abundance Desulfobacteria, while decreasing Firmicutes. Our results indicate above maximum residue limit have serious health consequences animals.

Язык: Английский

Процитировано

0