Targeting Cxcr4 and Trpv1 with Α-Conopeptide G1 Derived from Conus Geographus for Glioblastoma: An Integrative In-Silico and Network Pharmacology Approach
Опубликована: Янв. 1, 2025
Язык: Английский
Therapeutic Potential of Plant- and Marine-Derived Bioactive Compounds in Prostate Cancer: Mechanistic Insights and Translational Applications
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 286 - 286
Опубликована: Фев. 20, 2025
It
is
widely
recognized
that
prostate
cancer
a
multifaceted
illness
the
second
most
common
cause
of
cancer-related
fatalities
among
males.
Natural
sources
from
both
plants
and
marine
organisms
have
long
been
used
in
treating
various
diseases
discovery
new
pharmaceutical
compounds.
Medicinal
plants,
particular,
provide
bioactive
substances
like
alkaloids,
phenolic
compounds,
terpenes,
steroids.
In
addition,
natural
products
play
crucial
role
search
for
novel
treatments.
A
substantial
number
anticancer
drugs
derived
sources,
including
organisms,
microorganisms.
fact,
over
past
60
years,
80%
chemical
entities
originated
which
are
generally
considered
safer
than
synthetic
This
review
seeks
to
emphasize
phytochemical
compounds
plant
cancer,
highlighting
their
potential
therapeutic
impact.
also
intended
support
global
researchers
working
on
identification
natural-based
treatments
cancer.
Язык: Английский
Xanthocillin X Dimethyl Ether Exhibits Anti-Proliferative Effect on Triple-Negative Breast Cancer by Depletion of Mitochondrial Heme
Marine Drugs,
Год журнала:
2025,
Номер
23(4), С. 146 - 146
Опубликована: Март 28, 2025
Triple-negative
breast
cancer
(TNBC)
presents
a
significant
therapeutic
challenge
due
to
the
absence
of
specific
targeted
treatments.
In
this
study,
we
explored
potential
xanthocillin
X
dimethyl
ether
(XanDME),
naturally
occurring
isocyanide
isolated
from
marine
fungus
Scedosporium
apiospermum,
on
TNBC.
To
elucidate
underlying
mechanism,
initially
demonstrated
that
XanDME
directly
binds
hemin,
oxidized
form
heme,
in
vitro,
corroborating
previous
reports.
This
interaction
led
depletion
intracellular
regulatory
heme.
We
further
established
translocates
into
mitochondria,
where
it
interacts
with
crucial
hemoproteins,
namely
cytochromes.
The
binding
mitochondrial
cytochromes
disrupts
electron
transport
chain
(ETC),
inhibits
activity
complexes,
and
inactivates
respiration.
inhibitory
function
significantly
contributes
its
anti-TNBC
effects,
as
observed
both
vitro
vivo.
Our
study
underscores
against
TNBC,
warranting
investigations.
Язык: Английский