International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 9885 - 9885

Опубликована: Сен. 13, 2024

Maternal immune activation (MIA) during pregnancy has been increasingly recognized as a critical factor in the development of neurodevelopmental disorders, with potential sex-specific impacts that are not yet fully understood. In this study, we utilized murine model to explore behavioral and molecular consequences MIA induced by lipopolysaccharide (LPS) administration on embryonic day 12.5. Our findings indicate male offspring exposed LPS exhibited significant increases anxiety-like depression-like behaviors, while female did show comparable changes. Molecular analyses revealed alterations pro-inflammatory cytokine levels synaptic gene expression offspring, suggesting these disruptions may underlie observed differences. These results emphasize importance considering sex biological variable studies disorders highlight need for further investigations understand mechanisms driving outcomes. study contributes growing evidence prenatal challenges play pivotal role etiology underscores preventative approaches MIA.

Язык: Английский