Interaction of Phenanthroline-Containing Copper Complexes with Model Phospholipid Membranes DOI Creative Commons
Priscilla Freddi, Natalia Álvarez, Gianella Facchin

и другие.

Inorganics, Год журнала: 2024, Номер 12(12), С. 307 - 307

Опубликована: Ноя. 26, 2024

Medicinal Inorganic Chemistry has provided oncology with metallodrugs for cancer treatment, including several promising candidate drugs. In particular, copper(II) coordination compounds phenanthroline stand out as potential anticancer agents. this work, we used Differential Scanning Calorimetry and Electron Spin Resonance to investigate the interaction of copper complexes [Cu(phen)]2+ [Cu(L-dipeptide)(phenanthroline) (L-dipeptide: L-Ala-Gly L-Ala-Phe)) model lipid membranes (1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC, 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) sodium salt, DPPG). Our results showed that interact membrane models, fluidizing them. The presented a different localization than free ligand phen. dipeptide modulated complex in modifications induced physicochemical properties vesicles. A stronger DPPG anionic was observed, which mimic negatively charged surfaces, found on tumor cells.

Язык: Английский

Metallodrugs: Synthesis, mechanism of action and nanoencapsulation for targeted chemotherapy DOI
Jéssica Andreza Oliveira Rodrigues,

Neelakanta Sarvashiva Kiran,

Ankita Chatterjee

и другие.

Biochemical Pharmacology, Год журнала: 2024, Номер 231, С. 116644 - 116644

Опубликована: Ноя. 20, 2024

Язык: Английский

Процитировано

0
Interaction of Phenanthroline-Containing Copper Complexes with Model Phospholipid Membranes DOI Creative Commons
Priscilla Freddi, Natalia Álvarez, Gianella Facchin

и другие.

Inorganics, Год журнала: 2024, Номер 12(12), С. 307 - 307

Опубликована: Ноя. 26, 2024

Medicinal Inorganic Chemistry has provided oncology with metallodrugs for cancer treatment, including several promising candidate drugs. In particular, copper(II) coordination compounds phenanthroline stand out as potential anticancer agents. this work, we used Differential Scanning Calorimetry and Electron Spin Resonance to investigate the interaction of copper complexes [Cu(phen)]2+ [Cu(L-dipeptide)(phenanthroline) (L-dipeptide: L-Ala-Gly L-Ala-Phe)) model lipid membranes (1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC, 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) sodium salt, DPPG). Our results showed that interact membrane models, fluidizing them. The presented a different localization than free ligand phen. dipeptide modulated complex in modifications induced physicochemical properties vesicles. A stronger DPPG anionic was observed, which mimic negatively charged surfaces, found on tumor cells.

Язык: Английский

Процитировано

0