Postprandial Plasma Glucose between 4 and 7.9 Hours May Be a Potential Diagnostic Marker for Diabetes
Опубликована: Апрель 15, 2024
Postprandial
glucose
levels
between
4
and
7.9
hours
(PPG4–7.9h)
correlate
with
mortality
from
various
diseases
including
hypertension,
diabetes,
cardiovascular
disease,
cancer.
This
study
aimed
to
assess
if
predicted
PPG4–7.9h
could
diagnose
diabetes.
Two
groups
of
participants
were
involved:
Group
1
(4420
participants)
had
actual
PPG4–7.9h,
while
2
(8422
lacked
this
measure
but
all
the
diabetes
diagnostic
measures.
underwent
multiple
linear
regression
predict
using
30
predictors,
achieving
accuracy
within
11.1
mg/dL
in
80%
participants.
model.
Receiver
operating
characteristic
curve
analysis
showed
that
an
87.3%
2,
a
sensitivity
75.1%
specificity
84.1%
at
optimal
cutoff
102.5
mg/dL.
Simulation
on
10,000
random
samples
revealed
175
may
be
needed
investigate
as
marker
power
least
80%.
In
conclusion,
appears
promising
indicator
for
Future
studies
seeking
ascertain
its
definitive
value
might
require
minimum
sample
size
Язык: Английский
Postprandial Plasma Glucose between 4 and 7.9 h May Be a Potential Diagnostic Marker for Diabetes
Biomedicines,
Год журнала:
2024,
Номер
12(6), С. 1313 - 1313
Опубликована: Июнь 13, 2024
Postprandial
glucose
levels
between
4
and
7.9
h
(PPG4–7.9h)
correlate
with
mortality
from
various
diseases,
including
hypertension,
diabetes,
cardiovascular
disease,
cancer.
This
study
aimed
to
assess
if
predicted
PPG4–7.9h
could
diagnose
diabetes.
Two
groups
of
participants
were
involved:
Group
1
(4420
participants)
had
actual
PPG4–7.9h,
while
2
(8422
lacked
this
measure
but
all
the
diabetes
diagnostic
measures.
underwent
multiple
linear
regression
predict
using
30
predictors,
achieving
accuracy
within
11.1
mg/dL
in
80%
participants.
model.
A
receiver
operating
characteristic
curve
analysis
showed
that
an
87.3%
2,
a
sensitivity
75.1%
specificity
84.1%
at
optimal
cutoff
102.5
mg/dL.
simulation
on
10,000
random
samples
revealed
175
may
be
needed
investigate
as
marker
power
least
80%.
In
conclusion,
appears
promising
indicator
for
Future
studies
seeking
ascertain
its
definitive
value
might
require
minimum
sample
size
Язык: Английский
Fasting Triglycerides in the Upper Normal Range Are Independently Associated with an Increased Risk of Diabetes Mortality in a Large Representative US Population
Journal of Cardiovascular Development and Disease,
Год журнала:
2024,
Номер
11(4), С. 128 - 128
Опубликована: Апрель 21, 2024
The
association
between
normal-range
triglyceride
levels
and
diabetes
mortality
remains
unclear.
This
cohort
study
aimed
to
elucidate
this
relationship
by
examining
19,010
US
adult
participants
with
fasting
serum
triglycerides
below
150
mg/dL.
Cox
proportional
hazards
models
were
employed
estimate
hazard
ratios
(HRs)
95%
confidence
intervals
(CIs).
Participants
followed
up
for
a
mean
of
15.3
years,
during
which
342
deaths
recorded.
A
1
natural
log
unit
increase
in
was
associated
57%
higher
risk
(adjusted
HR,
1.57;
CI,
1.04-2.38).
Comparable
results
obtained
when
analyzed
quartiles.
Receiver
operating
characteristic
curve
analysis
identified
an
optimal
cutoff
94.5
mg/dL
mortality;
individuals
above
threshold
faced
greater
1.43;
1.12-1.83).
Further
investigation
revealed
positive
normal
all-cause
mortality,
though
no
observed
from
hypertension
or
cardiovascular
disease.
In
conclusion,
elevated
within
the
range
increased
mortality.
Individuals
95
may
require
vigilant
monitoring
its
complications.
Язык: Английский
The 2-Hour Plasma Glucose Levels During OGTT, Conducted in the Postprandial Period Between 4 and 7.9 Hours, Are Associated With the Diagnosis of Diabetes, Diabetes Mortality, and Cardiovascular Mortality
Опубликована: Июль 5, 2024
Postprandial
plasma
glucose
between
4
and
7.9
hours
is
associated
with
the
diagnosis
of
diabetes,
diabetes
mortality,
cardiovascular
mortality.
However,
it
unknown
whether
2-hour
during
oral
tolerance
test
conducted
in
this
postprandial
period
(4–7.9
hours),
termed
as
2-h
PGOGTT@4–7.9h,
can
accurately
classify
predict
mortality
risks.
This
study
aimed
to
address
these
questions
using
2,347
adult
participants.
Diabetes
was
defined
HbA1c
≥6.5%,
ability
PGOGTT@4–7.9h
analyzed
receiver
operating
characteristic
curves.
Cox
proportional
hazards
models
were
employed
estimate
hazard
ratios
(HRs)
95%
confidence
intervals
(CIs).
The
results
showed
that
could
92%
accuracy.
Participants
followed
up
for
a
mean
21.4
years.
A
1-natural-log
higher
an
increased
risk
from
(adjusted
HR,
21.1;
CI,
9.2–48.0)
disease
1.47;
1.13–1.91).
Simulation
analysis
indicated
future
studies
may
require
at
least
100
participants
investigate
diagnosis.
In
conclusion,
be
useful
classification
prediction
risk.
Язык: Английский
Postprandial Plasma Glucose With a Fasting Time of 4–7.9 h Is Positively Associated With Cancer Mortality in US Adults
Diabetes/Metabolism Research and Reviews,
Год журнала:
2024,
Номер
40(8)
Опубликована: Ноя. 1, 2024
ABSTRACT
Aims
This
study
investigated
the
association
of
postprandial
plasma
glucose
(PPG)
with
cancer
mortality
using
a
general
cohort
US
adults.
Materials
and
Methods
included
14,860
adults
who
attended
third
National
Health
Nutrition
Examination
Survey
from
1988
to
1994,
being
followed
up
until
December
31,
2019.
The
explanatory
variable
was
level
glucose,
including
PPG
fasting
time
0–3.9
h
(PPG
0–3.9h
)
4–7.9
4–7.9h
),
≥8
(PG
at
2
after
oral
tolerance
test
2hOGTT
).
Plasma
glucose‐associated
risk
assessed
Cox
proportional
hazard
models.
Results
A
1‐natural‐log‐unit
increase
in
associated
higher
multivariate‐adjusted
for
[hazard
ratio
(HR),
3.24;
95%
confidence
interval
(CI),
1.50–7.00].
However,
,
PG
haemoglobin
1c
insulin
were
not
significantly
mortality.
positive
remained
those
without
prior
diagnosis
cancer.
Conclusions
High
is
Lowering
may
reduce
Язык: Английский
The modified role including mediating and synergistic interactive effects of glucose tolerance status in the associations between relative fat mass and the risks of cardiovascular disease and all-cause mortality from the 4C cohort study
Diabetology & Metabolic Syndrome,
Год журнала:
2024,
Номер
16(1)
Опубликована: Дек. 26, 2024
To
investigate
the
associations
between
relative
fat
mass
(RFM)
and
clinical
outcomes
in
different
glucose
tolerance
statuses
modified
effect
of
status.
We
analyzed
8,224
participants
from
a
Chinese
cohort
study,
who
were
classified
into
normal
status
(NGT),
prediabetes,
diabetes.
Outcomes
included
fatal,
nonfatal
cardiovascular
disease
(CVD)
events
all-cause
mortality.
Associations
RFM
assessed
using
Cox
regression.
The
was
investigated
mediation,
interaction,
joint
analyses.
During
up
to
5
years
follow-up,
154
(1.9%)
experienced
fatal
CVD,
153
CVD
events,
294
(3.6%)
death.
2,679
(32.6%)
had
NGT,
4,528
(54.8%)
1,037
(12.6%)
associated
with
increased
risk
(HR
[95%
CI],
1.09
[1.06–1.12],
p
<
0.001),
1.12
[1.09–1.15],
mortality
1.10
[1.08–1.12),
0.001)
all
those
diabetes,
these
by
status,
which
mediating
(mediation
proportion
ranges
4.74%
8.69%)
synergistic
interactive
effects
(multiplicative
1.03
1.06).
analysis
identified
subclassification
that
exhibited
highest
HR
among
12
subclassifications.
could
significantly
influence
how
clinicians
assess
high
lead
more
personalized,
effective
prevention
strategies.
Язык: Английский