A Systematic Review of Endothelial Dysfunction in Chronic Venous Disease—Inflammation, Oxidative Stress, and Shear Stress DOI Open Access
Hristo Abrashev,

Despina Abrasheva,

N Nikolov

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3660 - 3660

Опубликована: Апрель 12, 2025

Chronic venous disease (CVD) is among the most common diseases in industrialized countries and has a significant socioeconomic impact. The diversity of clinical symptoms manifestations CVD pose major challenges routine diagnosis treatment. Despite high prevalence huge number surgical interventions performed every day, substantial proportion etiopathogenesis remains unclear. There are several widely advocated generally valid theories “peri-capillary fibrin cuffs” “white cell trapping hypothesis”, which consider role reflux/obstruction, inflammation, vascular remodeling, hemodynamic changes, genetic social risk factors. specific provoking factors for development reflux: incompetence valve system, inflammation wall, hypertension. Over past few years, increasing scientific data demonstrated link between oxidative stress, endothelial dysfunction, inflammation. High levels oxidants persistent can cause cumulative changes hemodynamics, resulting permanent irreversible damage to microcirculation cells. Production reactive oxygen species expression inflammatory cytokines adhesion molecules involved vicious cycle wall remodeling. interaction ROS, particular, superoxide anion radical, with nitric oxide leads decrease NO bioavailability, followed by initiation prolonged vasoconstriction hypoxia impairment tone. This review addresses ED, oxidative, stress mediation. Based on predefined inclusion exclusion criteria, we conducted systematic published articles using PubMed, PMC Europe, Scopus, WoS, MEDLINE, Google Scholar databases interval from 24 April 2002 1 2025. current included studies (n = 197) articles, including new reviews, updates, grey literature, were evaluated according eligibility criteria. selection process was standardized form PRISMA rules, manual search databases, double-check ensure transparent complete reporting reviews. Studies had report quantitative assessments relationship shear chronic disease.

Язык: Английский

Clinical Predictors of Aspirin Resistance in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis DOI Creative Commons
Fan Zhang,

Hongyan Zheng

Reviews in Cardiovascular Medicine, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 20, 2025

Background: Aspirin treatment is recommended as a secondary prevention strategy and could be potential primary for cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM). However, aspirin resistance notably common among diabetic patients, compromising the efficacy of treatment. Hence, our study sought to assess clinical predictors (AR) T2DM patients. Methods: We conducted systematic search three major medical databases (PubMed, Embase, Cochrane Library) identify relevant articles up September 17, 2024. Details publications investigated parameters were extracted from selected studies. The meta package R language software was utilized synthesize evidence concerning AR. applied either fixed- or random effects model based on heterogeneity observed included pooled results visually displayed using forest plots. Results: In total, 10 finally (n = 2113 patients). AR predominantly linked specific laboratory parameters, particularly those indicative heightened insulin inadequate lipid management. Specifically, associated fasting glucose level (mean difference (MD) 8.21; 95% confidence interval (CI) 2.55 13.88), glycated hemoglobin (MD 0.22; CI 0.06 0.38), high-density lipoprotein (HDL) –2.02; –3.62 –0.42), low-density (LDL) 7.00; 2.87 11.13), total cholesterol 9.52; 4.37 14.67), triglyceride levels 12.51; 3.47 21.55). Conclusions: Markers dyslipidemia blood are robust indicators individuals T2DM. These findings imply that assessing regulation enhance development personalized preventive approaches vascular complications diabetes. PROSPERO registration: CRD42023388170, https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=388170

Язык: Английский

Процитировано

0
Chronic Coronary Artery Disease: Wall Disease vs. Lumenopathy DOI Creative Commons
Ioannis Paraskevaidis, Christos Kourek, Elias Tsougos

и другие.

Biomolecules, Год журнала: 2025, Номер 15(2), С. 201 - 201

Опубликована: Янв. 31, 2025

Acute and chronic coronary artery disease (CAD) are interconnected, representing two facets of the same condition. Chronic CAD exhibits a dynamic nature, manifesting as stable or acute ischemia, both. Myocardial ischemia can be transient reversible. The genesis involves diverse anatomical functional mechanisms, including endothelial dysfunction, arteriolar remodeling, capillary rarefaction, perivascular fibrosis, though no single factor explains its heterogeneity. is often but may present symptomatic asymptomatic (e.g., in diabetes) affect various compartments (epicardial microcirculation). This complexity necessitates reappraisal our approach, pathophysiological mechanisms vary overlap. A comprehensive exploration these using advanced diagnostic techniques aid identifying processes underlying CAD. obstructive non-obstructive, unstable, underscoring diversity. primary source lies arterial wall, emphasizing need for research on components, such endothelium vascular smooth muscle cells, factors disrupting homeostasis. Shifting focus from luminal status to wall provide insights into atheromatous plaques, enabling earlier interventions prevent their development progression.

Язык: Английский

Процитировано

0
A Systematic Review of Endothelial Dysfunction in Chronic Venous Disease—Inflammation, Oxidative Stress, and Shear Stress DOI Open Access
Hristo Abrashev,

Despina Abrasheva,

N Nikolov

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3660 - 3660

Опубликована: Апрель 12, 2025

Chronic venous disease (CVD) is among the most common diseases in industrialized countries and has a significant socioeconomic impact. The diversity of clinical symptoms manifestations CVD pose major challenges routine diagnosis treatment. Despite high prevalence huge number surgical interventions performed every day, substantial proportion etiopathogenesis remains unclear. There are several widely advocated generally valid theories “peri-capillary fibrin cuffs” “white cell trapping hypothesis”, which consider role reflux/obstruction, inflammation, vascular remodeling, hemodynamic changes, genetic social risk factors. specific provoking factors for development reflux: incompetence valve system, inflammation wall, hypertension. Over past few years, increasing scientific data demonstrated link between oxidative stress, endothelial dysfunction, inflammation. High levels oxidants persistent can cause cumulative changes hemodynamics, resulting permanent irreversible damage to microcirculation cells. Production reactive oxygen species expression inflammatory cytokines adhesion molecules involved vicious cycle wall remodeling. interaction ROS, particular, superoxide anion radical, with nitric oxide leads decrease NO bioavailability, followed by initiation prolonged vasoconstriction hypoxia impairment tone. This review addresses ED, oxidative, stress mediation. Based on predefined inclusion exclusion criteria, we conducted systematic published articles using PubMed, PMC Europe, Scopus, WoS, MEDLINE, Google Scholar databases interval from 24 April 2002 1 2025. current included studies (n = 197) articles, including new reviews, updates, grey literature, were evaluated according eligibility criteria. selection process was standardized form PRISMA rules, manual search databases, double-check ensure transparent complete reporting reviews. Studies had report quantitative assessments relationship shear chronic disease.

Язык: Английский

Процитировано

0